CHANGES IN ENDOMETRIAL CANCER CLINICAL AND MORPHOLOGICAL FEATURES DURING THE PAST HALF CENTURY

Abstract

Objective of the study was to compare the characteristics of endometrial cancer (EC) in patients observed in years 1965 - 1969, 1995 - 1999 and 2012 - 2015.

Results. The research was conducted on the basis of the same institution and it showed that over the past 50 years (1965 to 2015) an increase in the average age of women with primary EC. Despite the increase by through the decades in relatively favorable endometrial adenocarcinomas in relation to non-endometrioid tumors, with the increasing age of patients the incidence of non-endometrioid carcinomas increased especially due to women older than 60 years compared with patients younger than 50 years. This was reflected in such characteristics as stage of the process (according to FIGO), degree of tumor differentiation, proportion of serous carcinomas and expression of HER-2/neu.

Conclusion. Taken into account contemporary renewal of molecular-biological classification of endometrial cancer types the data collected in this study may also have practical value in particular for decisions related to personalized conservative therapy options.