EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC)
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Keywords

PERITONEAL CARCINOMATOSIS
REGIONAL CHEMOTHERAPY
AEROSOL CHEMOTHERAPY
PIPAC

How to Cite

Zakharenko, A., Bagnenko, S., Yakovleva, M., Blyum, N., Ten, O., Zaytsev, D., Trushin, A., Belyaev, M., Natkha, A., & Kovalchuk, Y. (2017). EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC). Voprosy Onkologii, 63(3), 490–496. https://doi.org/10.37469/0507-3758-2017-63-3-490-496

Abstract

Peritoneal carcinomatosis (PC) is one of metastatic spread variant of malignant tumors, which shows significantly poor prognosis in patients. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) - is a modern regional therapy method for implantation metastases. Currently there are still unresolved issues in native equipment, optimal chemotherapy drugs doses for PIPAC, ability in adjuvant and neoadjuvant application of method and a combination with surgical treatment. Concerning this we carried out series of experimental studies on animal model (rabbits, n=71), which resulted in development of the device for laparoscopy aerosol chemotherapy also with selection of effective and safe PIPAC mode.
https://doi.org/10.37469/0507-3758-2017-63-3-490-496
##article.numberofdownloads## 27
##article.numberofviews## 128
PDF (Русский)

References

Cotte E., Passot G., Gilly F.N., Glehen O. Selection of patients and staging of peritoneal surface malignancies // World J. Gastrointest. Oncol. - 2010. - Vol. 2. - P 31-35.

Heldin C.H. High interstitial fluid pressure - an obstacle in cancer therapy // Nat. Rev. Cancer. - 2004. - Vol. 4. - № 8. - P 806-813.

Henderickson D.A. History and instrument of laparoscopic surgery// Vet. Clin. Nor. Am. Equ. Pract. - 2000. - Vol. 16. - P. 233-248.

Loggie B.W., Fleming R.A., McQuellon R.P et al. Cytore-ductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of gastrointestinal origin // Am. Surg. - 2000. - Vol. 66. - P 561-567.

Reymond M. A. Feasibility of therapeutic pneumoperitoneum in a large animal model using a microvaporisator // Surg. Endoscopy. - 2000. - Vol. 14. - P. 51-55.

Reymond M.A. Intraperitoneal Chemotherapy of Peritoneal Carcinomatosis Using Pressurized Aerosol as an Alternative to Liquid Solution: First Evidence for Efficacy // Ann. Surg. Oncol. - 2014. - Vol. 21. - P. 553-559.

Sadeghi B., Arvieiix C., Glehen O., et al. Peritoneal carcinomatosis from non-gynecologic malignancies results of the EVOCAPE 1 multicentric prospective study // Cancer. - 2000. - Vol. 88. - P. 358-363.

Sugarbaker P. H. Hyperthermic intraoperative intraperitoneal chemotherapy for the treatment of resectable gastric cancer // 4th International gastric cancer congress. - New York, 2001. - P. 336.

Sugerbaker PH. Management of peritoneal metastases -Basic concepts // Buon J. - 2015. - Vol. 20. - Р 2-11.

Tempter C.B., Celik I., Solass W. et al. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with cisplatin and doxorubicin in women with recurrent, platinum-resistant ovarian cancer: preliminary clinical experience // Gynecol. Oncol. - 2014. - Vol. 132. - № 2. - P. 307-311.

Verwaal V.J., van Ruth S., de Bree E. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer // J. Clin. Oncol. - 2003. - Vol. 21. - Р 3737- 3743.

Yoo C.H., Noh S.H., Shin D.W. et al. Early postoperative intraperitoneal chemotherapy (EPIC) for advanced gastric cancer // 3rd International gastric cancer congress, Seoul, 1999. - P. 103.

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