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The analysis of the effectiveness of treatment was carried out in 257 patients with squamous cell carcinoma of the mucous membranes of the oral cavity and oropharynx. There were used two methods of irradiation in combination with concurrent poly chemotherapy: standard radiotherapy (2 Gy 5 times a week) and radiation therapy in non-traditional modes of fractionation with uneven crushing of daily dose into two fractions (1 Gy + 1.5 Gy or 1 Gy + 2 Gy with 4-hour intervals) to a focal dose of 60 Gy. Chemoradiotherapy with crushing dose was more effective than standard chemoradiotherapy in frequency of objective tumor responses and regional metastases in the absence of increasing the number of early radiation reactions and late radiation damages. External beam radiotherapy in non-traditional modes of fractionation with simultaneous polychemotherapy exposure can significantly improve the results of the overall five-year survival compared with conventional fractionation technique — 60,4 ± 4,5%, 63,3 ± 8,2% vs 27,6 ± 10,2 %, respectively.References
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