DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES
Vol. 63 No. 4 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH
Vol. 63 No. 4 (2017)

DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH
https://doi.org/10.37469/0507-3758-2017-63-4-614-621
Published 01.04.2017
Igor Berlev
N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University
Yekaterina Nekrasova
N.N. Petrov Research Institute of Oncology
Gayk Mkrtchyan
N.N. Petrov Research Institute of Oncology
Yevgeniya Bezhanova
N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University
Katran Guseynov
N.N. Petrov Research Institute of Oncology
Yelena Ulrikh
N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University
Viktoriya Bashlyk
N.N. Petrov Research Institute of Oncology
Anna Artemeva
N.N. Petrov Research Institute of Oncology
Tatyana Semiglazova
N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University
Aleksandra Kondakova
N.N. Petrov Research Institute of Oncology
Andrey Mishchenko
N.N. Petrov Research Institute of Oncology
Nikolay Mikaya
N.N. Petrov Research Institute of Oncology
Adiliya Urmancheeva
N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University
Nikolay Bondarev
N.N. Petrov Research Institute of Oncology
O. Smirnova
N.N. Petrov Research Institute of Oncology
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Keywords

LOCALLY ADVANCED CERVICAL CANCER
DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY
PATHOMORPHOLOGICAL RESPONSE
YPCR
CR

How to Cite

Berlev, I., Nekrasova, Y., Mkrtchyan, G., Bezhanova, Y., Guseynov, K., Ulrikh, Y., Bashlyk, V., Artemeva, A., Semiglazova, T., Kondakova, A., Mishchenko, A., Mikaya, N., Urmancheeva, A., Bondarev, N., & Smirnova, O. (2017). DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES. Voprosy Onkologii, 63(4), 614–621. https://doi.org/10.37469/0507-3758-2017-63-4-614-621
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Abstract

In 24 patients (mean age 48 years) with locally advanced cervical cancer there were studied the efficacy and toxicity of 3 cycles of neoadjuvant dose-intensive chemotherapy with cisplatin (75 mg/m2) and doxorubicin (35 mg/m2) administered intravenously on the first day of a two- week cycle with the support of colony-stimulating factors. An important criterion for the inclusion in this study of patients with locally advanced cervical cancer (T1b2-2bN0-1M0) was the absence of infiltration of the anterior parameters according to the gynecological examination and MRI studies. An objective response to treatment was registered in 72.7 % of cases. Progression of the disease was not detected in any case. Conducting neoadjuvant drug therapy allowed performing radical surgical intervention in 95.4 % of patients. The pathomorphlogical response of tumor of varying severity was 40.9 %. In 9.1 % complete clinical regression of tumor was confirmed by a complete pathomor-phological response (CR). The dose-intensive regimen of chemotherapy did not lead to a significant increase of complications on the drug and surgical stages. An analysis showed that dose-intensive neoadjuvant chemotherapy is a highly effective method in treatment for locally advanced cervical cancer.

https://doi.org/10.37469/0507-3758-2017-63-4-614-621
##article.numberofdownloads## 26
##article.numberofviews## 259
PDF (Русский)

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