Abstract
A study of the prognostic role of microvessel density in tumors of patients with stage I-II non-small cell lung cancer (NSCLC) was performed from June 2008 to June 2011. Determination of microvessel density using the marker CD31 was conducted in 114 patients. Microvessel density was significantly correlated with tumor size: so at greater than 3 cm in diameter, the content of microvessels was 68,7 ± 3,1, with a smaller tumor size — 48,6 ± 4 ,5. Independent prognostic markers in patients with stage I-II NSCLC after surgery are histological type (HR = 2,97), tumor size (HR = 4,5), and the number of microvessels in tumor (HR = 3,2).References
Bosari S., Lee A.K., DeLellis R.A. et al. Microvessel quantitation and prognosis in invasive breast carcinoma // Hum. Pathol. — 1992. — Vol. 23. — P. 755-761.
Cox G, Jones J L, Andi A, et all. A biological staging model for operable non-small cell lung cancer // Thorax. — 2001. — Vol. 56. — P. 561-566.
Donnem T., Al-Saad S., Al-Shibli K. et all. Inverse prognostic impact of angiogenic marker expressionin tumor cells versus stromal cells in non-small cell lung cancer // Clin Cancer Res. — 2007. — Vol. 13. — P. 6649-6657.
Duarte I.G., Bufkin B.L., Pennington M.F. et al. Аngiogenesis as a predictor of survival after surgical resection for stage I non-small-cell lung cancer // J Thorac Cardiovasc Surg. — 1998. — Vol. 115. — P. 652-659.
Folkman J, Merler E, Abernathy C, Williams G. Isolation of a tumor factor responsible for angiogenesis // J Exp Med. 1971. — Vol. 133. — P. 275-288.
Fontanini G., Lucchi M., Vignati S. et al. Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study // J Nat Cancer Inst. — 1997. — Vol. 89. — P 881-886.
Giatromanolaki A., Koukourakis M.I., Theodossiou D., et al. Comparative evaluation of angiogenesis assessment with anti-factor-VIII and anti-CD31 immunostaining in nonsmall cell lung cancer // Clin Cancer Res. — 1997. — Vol. 3. — P. 2485-2492.
Guo J.F., Higashi K., Ueda Y et al. Microvessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas // J Nucl Med. — 2006. — Vol. 47. — P. 419-425.
Kakolyris S., Giatromanolaki A., Koukourakis M. et al. Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: correlation with p53 and angiogenic factor expression // Cancer Res. — 1999. — Vol. 59. — P. 5602-5607.
Macchiarini P., Fontanini G., Hardin M.J. et al. Relation of neovascularization to metastasis of non-small-cell lung cancer // Lancet 1992. — Vol. 340. — P. 145-146.
Matsuyama K., Chiba Y, Sasaki M. et al. Tumor angiogen-esis as a prognostic marker in operable non-small cell lung cancer // Ann Thorac Surg. — 1998. — Vol. 65. — P. 1405-1409.
Milas I., Komaki R., Hachiya T., et al. Association of VEGF, CD-34, E-cadherin and MMP-9 expression of the primary non-small cell lung cancer lesion with brain metastatic lesion // Proc Amer Assoc Cancer Res. — 2004. — Vol. 45. — Abst. #1919.
Mineo T.C., Ambrogi V., Baldi A. et al. Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer // J Clin Pathol. — 2004. — Vol. 57. — P. 591-597.
Nia P.S., Marck E.V., Weyler J., Schil P.V. Prognostic value of a biologic classification of non-small-cell lung cancer into the growth patterns along with other clinical, pathological and immunohistochemical factors // Europ. J Cardio -thoracic Surgery. — 2010. — Vol. 38. — P. 628-636.
Ohta Y, Tomita Y, Oda M. et al. Tumor angiogenesis and recurrence in stage I non-small cell lung cancer // Ann Thorac Surg. — 1999. — Vol. 68. — P 1034-1038.
Pusztaszeri M.P, Seelentag W., Bosman F.T. Immuno-histochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues // J Histochem Cytochem. — 2006. — Vol. 54. — P. 385.
Singhal S., Vachani A., Antin-Ozerkis D. et al. Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: A Review // Clin Cancer Res. — 2005. — Vol. 11. — P. 3974-3986.
Tanaka F., Otake Y, Yanagihara K. et al. Evaluation of an-giogenesis in non-small cell lung cancer: comparison between Anti-CD34 antibody and anti-CD105 antibody // Clin Cancer Res. — 2001. — Vol.7. — P. 3410-3415
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