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Abstract
There was examined the role of VEGFA in the induction of malignant hemangioendothelioma (HAE) in the non-vascular tissue of renal capsule (RC) in mice. Expression mRNA VEGFA and its receptor Flk1 in RC and the kidneys in male mice of CBA and C57Bl/6 lines was studied at different stages of the administration of a chemical carcinogen 1,2-dimethylhydrazine (DMH), which induced HAE of PC in CBA males with a high frequency, and in C57Bl/6 line — with a low frequency. In the kidneys of male mice of both lines at all stages there was observed significant expression both VEGFA and Flk1 but no linear differences were found. In RC of these mice expression of studied genes were not found. Only at the last stage of carcinogenesis in RC of resistant line C57Bl/6 and in HAE of RC of line CBA there was appeared weak expression of mRNA VEGFA but mRNA Flk1 was not expressed. A similar profile of expression is appropriate more for pericytes and macrophages but not endothelial cells indicating either on the origin of HAE RC from non-endothelial cells or on atypia of endothelial cells — progenitors of this tumor.References
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