Radiation therapy for medullary thyroid carcinoma

Abstract

The paper analyzes the effectiveness of external beam radiation therapy of medullary thyroid cancer in 38 patients. The radiation therapy of the first phase combined therapy was performed in 9 (24 %) patients: after treatment, 5 patients had a partial response, 4 — stabilization. The radiation therapy of the second phase combined therapy was performed in 27 (71%) patients: after treatment, 2 patients had a complete response (booster method), 5 — partial response, 4 — stabilization. External beam therapy has been performed in 2 (5 %) patients with palliative and symptomatic goals. Additionally has been estimated level of calcitonin in patients after combined treatment. The calcitonin level becomes normal without radiation therapy. Therefore, exposure for medullary thyroid carcinoma is questionable (exception for cases gain exposure to the rest of the tumor).
https://doi.org/10.37469/0507-3758-2013-59-6-781-784
PDF (Русский)

References

Пачес А.И. Пропп Р.М. Рак щитовидной железы // Москва, «Медицина». — 1995-372 с.

Румянцев П.О., Ильин А.А., Румянцева У.В., Газизова Д.О. Факторы клинического прогноза медуллярного рака щитовидной железы // Опухоли головы и шеи. — 2011. — Т. 4. — С. 48-53.

Brierley J., Sherman E. The role of external beam radiation and targeted therapy in thyroid cancer // Semin. Radiat. Oncol. — 2012 — Vol. 22. — P 254-262.

Dequanter D., Lothaire P. Medullary thyroid cancer: surgical results and prognostic factors // Rev. Med. Liege. — 2010- Vol. 65. — P 450-452.

Mazzaferri E.L., de los Santos E.T., Rofagha-Keyhani S. Solitary thyroid nodule: diagnosis and management // Med. Clin. North. Am. — 1988 — Vol. 72. — P. 11771211.

Oshiro C., Kamigaki S., Arai T. et al. A case of thyroid medullary carcinoma with multiple painful bone metastases successfully treated with strontium-89 chloride // Gan To Kagaku Ryoho. — 2012 — Vol. 39. — P. 951-953.

Panigrahi B., Roman S.A., Sosa J.A. Medullary thyroid cancer: are practice patterns in the United States discordant from American Thyroid Association guidelines? // Ann. Surg. Oncol. — 2010 — Vol. 17. — P. 1490-1498.

Roman S., Lin R., Sosa J.A. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases // Cancer. — 2006 — Vol. 107. — P. 2134-2142.

Schwartz D.L., Rana V., Shaw S. et al. Postoperative radiotherapy for advanced medullary thyroid cancerlocal disease control in the modern era // Head Neck. — 2008 — Vol. 30. — P. 883-888.

Sobin L., Wittekind C. (eds.) TNM classification of malignant tumors, 6th edition // New York: Wiley-Liss. — 2002-239 p.

Stanković V., Borojević N., Dzodić R., Golubicić I. Medullary carcinoma of the thyroid gland: effect of postoperative transcutaneous radiotherapy on local control and results of treatment // Acta. Chir. Iugosl. — 2003 — Vol. 50. — P. 125-130.

Strasser J.F., Raben A., Koprowski C. The role of radiation therapy in the management of thyroid cancer // Surg. Oncol. Clin. N. Am. — 2008 — Vol. 17. — P 219 — 232.

Sugawara M., Ly T, Hershman J.M. Medullary thyroid cancer-current treatment strategy, novel therapies and perspectives for the future // Horm. Cancer. — 2012 — Vol. 3. — P. 218-226.

Terezakis S.A., Lee N.Y The role of radiation therapy in the treatment of medullary thyroid cancer // J. Natl. Compr. Canc. Netw. — 2010 — Vol. 8. — P. 532-540.

Voutilainen P.E., Multanen M., Haapiainen R.K. et al. Long term prognosis of medullary thyroid carcinoma in 39 patients // Ann. Chir. Gynaecol. — 2000 — Vol. 89. — P. 292-297.

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