Proliferation of stem cancer cells in colorectal adenocarcinoma
Vol. 69 No. 5 (2023), Articles
Vol. 69 No. 5 (2023)

Proliferation of stem cancer cells in colorectal adenocarcinoma

Articles
https://doi.org/10.37469/0507-3758-2014-60-1-47-51
Published 15.12.2014
Russian Research Centre for Radiology and Surgical Technologies
Saint Petersburg State University
Kazan State Medical University
Saint Petersburg State 1.1. Mechnikov North-West State Medical University
Russian Research Centre for Radiology and Surgical Technologies
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Keywords

ALDH1
Ki-67

How to Cite

, , , , & . (2014). Proliferation of stem cancer cells in colorectal adenocarcinoma. Voprosy Onkologii, 69(5), 47–51. https://doi.org/10.37469/0507-3758-2014-60-1-47-51
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Abstract

Correlation between level of ALDH1 expression and metastases development in patients with colorectal adenocarcinoma was not revealed. Proliferation of stem cancer cells (ALDH1-positive) was significantly lower comparatively ALDH-1 negative tumor cells (p<0,001). Proliferation of stem cancer cells vary from 0,1% to 10%.
https://doi.org/10.37469/0507-3758-2014-60-1-47-51
##article.numberofdownloads## 32
##article.numberofviews## 77
PDF (Русский)

References

Пожарисский К.М. Опухоли кишечника, индуцированные у крыс 1,2 - диметилгидразином // Вопр. онкол. - 1972. - Т. 18. - №1. - С. 64-71.

Пожарисский К.М. Экспериментальный анализ морфогенеза и патогенеза эпителиальных опухолей кишечника // Автореферат диссертации на соискание ученой степени доктора медицинских наук. - Ленинград. - 1978. - 27 С.

Раскин Г.А., Орлова Р.В., Протасова А.Э. и др. Роль стволовых раковых клеток, хемокинов и их рецепторов в канцерогенезе, рецидивировании и метастазировании опухолей // Вопр. онкол. - 2013. - Т. 59. - С. 694-700.

Buczacki S., Davies R.J., Winton D.J. Stem cells, quiescence and rectal carcinoma: An unexplored relationship and potential therapeutic target // Br J Cancer. - 2011. - Vol. 105. - P 1253-1259.

Dittmer J., Rody A. Cancer stem cells in breast cancer // HistolHistopathol. - 2013. - Vol. 28(7). - P. 827-838.

Fluge., Gravdal K., Carlsen E., Vonen B. et al. Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis // Br J Cancer. - 2009. - Vol. 101. - P. 1282-1289.

Ghods A.J., Irvin D., Liu G. et al. Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells // Stem Cells. - 2007. - Vol. 25. - P 1645-1653.

Ginestier C., Hur M.H., Charafe-Jauffret E. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome // Cell Stem Cell. - 2007. - Vol. 15. - P. 555-567.

Gupta P.B., Fillmore C.M., Jiang G. et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells // Cell. - 2011. - Vol. 146. - P. 633-644.

Haraguchi N., Utsunomiya T., Inoue H. et al. Characterization of a side population of cancer cells from human gastrointestinal system // Stem Cells. - 2006. - Vol. 24. - P. 506-513.

Hirsch D., Barker N., McNeil N. et al. LGR5 positivity defines stem-like cells in colorectal cancer // Carcinogenesis. - 2013. - online.

Jiang F, Qiu Q., Khanna A. et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker // Mol Cancer Res. - 2009. - Vol. 7(3). - P. 330-338.

Li H., Ma F., Wang H. et al. Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer // Int J Biol Markers. -2013. - Vol. 28. - Р. 357-364.

Li L., Clevers H. Coexistence of quiescent and active adult stem cells in mammals // Science. - 2010 - Vol. 327. - P. 542-545.

Liu G., Yuan X., Zeng Z. et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma // Mol Cancer. - 2006. - Vol. 5. - P. 67-71.

Montgomery R. K., Carlone D.L., Richmond C.A. et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells // Proc. NatlAcad.Sci. USA - 2011. - Vol. 108. - P. 179-184.

Potten C.S., Gandara R., Mahida YR. et al. The stem cells of small intestinal crypts: where are they? // Cell Prolif. - 2009. - Vol. 42. - P 731-750.

Saigusa S., Tanaka K., Toiyama Y et al. Immunohisto-chemical features of CD133 expression: association with resistance to chemoradiotherapy in rectal cancer // Oncol Rep. - 2010. - Vol. 24. - P. 345-350.

Salminen E., Palmu S., Vahlberg T. et al. Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer // World J Gastroenterol. - 2005. - Vol. 11. - P. 3245 - 3249.

Sangiorgi E., Capecchi M. R. Bmi1 is expressed in vivo in intestinal stem cells // Nature Genet. - 2008. - Vol. 40. - P. 915-920.

Sato T., van Es J.H., Snippert H.J., Stange D.E. et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts // Nature. - 2011. - Vol. 469. - P. 415-418.

Takahashi H., Ishii H., Nishida N. et al. Significance of Lgr5(+ve) cancer stem cells in the colon and rectum // Ann SurgOncol. - 2011. - Vol. 18. - P. 1166-1174.

Takeda K., Kinoshita I., Shimizu Y et al. Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis // Anticancer Res. - 2011. -Vol. 31. - P. 263-270.

Tian H., Biehs B., Warming S. et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable // Nature. - 2011. - Vol. 478. - P. 255-259.

Vermeulen L., De Sousa E. Melo F., van der Heijden M. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment // Nat Cell Biol. - 2010. - Vol. 12. - P. 468-476.

Choi A.R., Park J.R., Kim R.J. et al. Inhibition of Wnt1 expression reduces the enrichment of cancer stem cells in a mouse model of breast cancer // Biochem Biophys Res Commun. - 2012. - Vol. 425. - P. 436-442.

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