Vol. 65 No. 1 (2019), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 65 No. 1 (2019)

POSSIBILITIES OF 18F-FDG PET/CT IN THE DIAGNOSIS AND STAGING OF LYMPHOMAS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-1-147-153

Published 01.01.2019

Natalya Chanchikova⁺⁻
Yekaterina Dudnikova⁺⁻
Yelena Karlova⁺⁻
Anastasiya Saveleva⁺⁻
O. Silkina⁺⁻
Roman Zelchan⁺⁻
Ivan Sinilkin⁺⁻
Olga Bragina⁺⁻
Anna Medvedeva⁺⁻
Vladimir Chernov⁺⁻

Natalya Chanchikova

The Federal State-Financed Institution Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency

Yekaterina Dudnikova

Tomsk National Research Medical Center of the Russian Academy of Sciences

Yelena Karlova

The Federal State-Financed Institution Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency

Anastasiya Saveleva

The Federal State-Financed Institution Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency

O. Silkina

The Federal State-Financed Institution Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency

Roman Zelchan

Tomsk National Research Medical Center of the Russian Academy of Sciences

Ivan Sinilkin

Tomsk National Research Medical Center of the Russian Academy of Sciences

Olga Bragina

Tomsk National Research Medical Center of the Russian Academy of Sciences

Anna Medvedeva

Tomsk National Research Medical Center of the Russian Academy of Sciences

Vladimir Chernov

Tomsk National Research Medical Center of the Russian Academy of Sciences, National Research Tomsk Polytechnic University

##article.numberofdownloads## 288

##article.numberofviews## 458

PDF (Русский)

Keywords

ЛИМФОПРОЛИФЕРАТИВНЫЕ ЗАБОЛЕВАНИЯ
ЛИМФОМА ХОДЖКИНА
НЕХОДЖКИНСКИЕ ЛИМФОМЫ
КОМПЬЮТЕРНАЯ ТОМОГРАФИЯ
ПОЗИТРОННО ЭМИССИОННАЯ ТОМОГРАФИЯ

How to Cite

Chanchikova, N., Dudnikova, Y., Karlova, Y., Saveleva, A., Silkina, O., Zelchan, R., Sinilkin, I., Bragina, O., Medvedeva, A., & Chernov, V. (2019). POSSIBILITIES OF 18F-FDG PET/CT IN THE DIAGNOSIS AND STAGING OF LYMPHOMAS. Voprosy Onkologii, 65(1), 147–153. https://doi.org/10.37469/0507-3758-2019-65-1-147-153

Abstract

The aim of the study was to evaluate the effectiveness of 18F-FDG PET/CT in lymphomas staging compared with traditional diagnostic methods. The results of 18F-FDG PET/ CT of 30 patients with malignant lymphomas were analyzed. The analysis showed high efficiency of 18F-FDG PET/CT compared with standard clinical and instrumental methods of research. This method has demonstrated the greatest diagnostic value in the diagnosis of involvement of the iliac, mediastinal, mesenteric and inguinal lymph nodes in the tumor process, as well as in extronadal lesions (red bone marrow, soft tissues, lungs and spleen), when sensitivity was 90% or more. The mismatch between the results of traditional research methods and 18F-FDG PET/CT in lymphoma staging was found in 12 (40%) patients: in 4 cases 18F-FDG PET/CT allowed to lower the stage of the disease, and in 8 patients to increase, which allowed correcting the therapy in 23% of patients. Thus, the results of the study indicate a high efficacy of 18F-FDG PET/ CT for malignant lymphomas staging.

https://doi.org/10.37469/0507-3758-2019-65-1-147-153

##article.numberofdownloads## 288

##article.numberofviews## 458

PDF (Русский)

References

Аль-Ради Л.С., Барях Е.А., Белоусова И.Э. и др. Российские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний // Современная онкология. - 2014. - № S. - С. 6-126.

Асланиди И.П., Мухортова О.В., Шурупова И.В. и др. Позитронно-эмиссионная томография: уточнение стадии болезни при злокачественных лимфомах // Клиническая онкогематология. Фундаментальные исследования и клиническая практика. - 2010. - Т. 3. - № 2. - С. 119-129.

Гематология: национальное руководство. Под ред. Рукавицина О.А. - М.: Геотар-Медиа, 2015. - 912 с.

Злокачественные новообразования в России в 2016 году (заболеваемость и смертность) Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. - М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2018. - 250 с.

Канаев С.В., Новиков С.Н., Гершанович М.Л. Значение радионуклидной визуализации костного мозга и селе зенки в выборе лечебной тактики и топометрической подготовке больных Лимфомой Ходжкина к облучению // Вопросы онкологии. - 2002. - Т. 48. - С. 193.

Канаев С.В., Новиков С.Н., Гершанович М.Л., Жукова Л.А. Значение непрямой лимфосцинтиграфии для определения тактики лучевого лечения больных Лимфомой Ходжкина // Вопросы онкологии. - 2002. - Т. 48. - С. 37.

Канаев С.В., Новиков С.Н., Гиршович М.М. и др. Значение методов ядерной медицины для определения тактики лучевого лечения у больных со злокачественными новообразованиями различной локализации // Вопросы онкологии. - 2012. - Т. 58. - № 2. - С. 189-193.

Канаев С.В., Новиков С.Н., Леенман Е.Е. Сравнительный анализ данных трепанобиопсии и радионуклидной визуализации костного мозга // Вопросы онкологии. 2001. - Т. 47. - С. 566.

Новиков С.Н., Гиршович М.М. Диагностика и стадирование лимфомы Ходжкина // Проблемы туберкулеза и болезней легких. - 2007. - Т. 8. - № 2 (30). - С. 65-72.

A clinical evaluation of the International Lymphoma Study Group classification of non,Hodgkin's lymphoma. The Non, Hodgkin's Lymphoma Classification Project // Blood. - 1997. - Vol. 89. - P. 3909-3918.

Barrington SF, Mikhaeel NG, Kostakoglu L et al. Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group // J. Clin. Oncol. - 2014. - Vol. 32. - P. 3048-58.

Cheson BD, Pfistner B, Juweid ME et al. Revised response criteria for malignant lymphoma // J Clin Oncol.- 2007. -Vol. 25. - P. 579-86.

Cheson BD. Role of functional imaging in the management of lymphoma // J Clin Oncol. 2011. - 29. - P 1844-54.

Dreyling M, Thieblemont C, Gallamini A et al. ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma // Ann Oncol.- 2013. -Vol. 24. - P 857-77.

Elstrom RL, Leonard JP, Coleman M, Brown RK. Combined PET and low-dose, noncontrast CT scanning obviates the need for additional diagnostic contrast-enhanced CT scans in patients undergoing staging or restaging for lymphoma // Ann Oncol. - 2008. -Vol. 19. - P. 1770-3.

Freudenberg LS, Antoch G, Schutt P et al. FDG-PET/CT in re-staging of patients with lymphoma // Eur J Nucl Med Mol Imaging. - 2004. -Vol. 31. - P. 325-9

Hutchings M, Loft A, Hansen M et al. Position emission tomography with or without computed tomography in the primary staging of Hodgkin's lymphoma // Haematologica. - 2006. -Vol. 91. - P. 482-9.

Kwee TC, Kwee RM, Nievelstein RA. Imaging in staging of malignant lymphoma: a systematic review // Blood.- 2008. -Vol. 111. - P. 504-16.

Moog F, Kotzerke J, Reske SN. FDG PET can replace bone scintigraphy in primary staging of malignant lymphoma // J Nucl Med. - 1999. -Vol. 40. - P 1407-13.

Pelosi E, Pregno P, Penna D et al. Role of whole-body [18F] fluorodeoxyglucose positron emission tomography/ computed tomography (FDG-PET/CT) and conventional techniques in the staging of patients with Hodgkin and aggressive non Hodgkin lymphoma // Radiol Med. - 2008. -Vol. 113. - P 578-90.

Zelenetz AD, Wierda WG, Abramson JS et al. Non-Hodgkin's Lymphomas, version 3.2012 // J Natl Compr Canc Netw. -2012. - 10. - P 1487-98

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

Yuliya Belevich, Yelena Simolina, Vitalina Vysotskaya, Nataliya Popova, Denis Kulbakin, Aleksey Goldberg, Zhanna Startseva, Vladimir Chernov, Irina Frolova, Svetlana Chizhevskaya, Viktor Goldberg, Yevgeniy Choynzonov, Yekaterina Dudnikova, ANTITUMOR CHEMOTHERAPY IN COMBINED TREATMENT OF PATIENTS WITH CANCER OF THE LARYNX AND HYPOPHARYNX , Voprosy onkologii : Vol. 64 No. 5 (2018)
Alyena Chernyshova, Vitaly Аntipov, Larisa Коlomiets, Vladimir Chernov, Victor Gyunter, Ekaterina Маrchenko, Timofei Chekalkin, Experience of performing radical trachelectomy with uterine transposition in organ-preserving treatment of stage IB-II invasive cervical cancer , Voprosy onkologii : Vol. 67 No. 1 (2021)
Olga Bragina, Vladimir Chernov, Sergei Deev, Roman Zelchan, Anna Medvedeva, Natalia Lukina, Viktor Goldberg, Vladimir Tolmachev, Comparative analysis of the use of technetium-99m labeled recombinant target molecules at doses of 1000 and 2000 μg for radionuclide diagnostics of HER2-positive breast cancer , Voprosy onkologii : Vol. 68 No. 1 (2022)
Evgeniy Olegovich Rodionov, Vladimir Chernov, Denis Evgen'evich Kulbakin, Elena Vladimirovna Obkhodskaya, Artem Viktorovich Obkhodsky, Viktor Ivanovich Sachkov, Sergey Viktorovich Miller, Sensor-Based Gas Analysis System for Lung Cancer Diagnosis , Voprosy onkologii : Vol. 69 No. 5 (2023)
Ol`ga Bragina, Vladimir Chernov, Liubov Tashireva, Roman Zelchan, Anna Medvedeva, Viktor Goldberg, Vladimir Tolmachev, Determination of the most informative prognostic parameters for assessing the status of the epidermal growth factor receptor Her2/neu in the primary tumor in breast cancer patients using the targeted radiopharmaceutical «99mTc-ADAPT6» , Voprosy onkologii : Vol. 67 No. 3 (2021)
Anna Medvedeva, Vladimir Chernov, Roman Zelchan, Olga Bragina, Anastasiya Rуbina, Artem Doroshenko, Evgenii Garbukov, Using the results of single-photon emission computed tomography with [99mTc]-MIBI at the stages of preoperative therapy in patients with breast cancer , Voprosy onkologii : Vol. 68 No. 4 (2022)