A Case of Keratinizing Squamous Cell Carcinoma of the Lung with Myocardial Carcinomatosis
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Keywords

lung cancer
keratinizing squamous cell
metastases
myocardium

How to Cite

Alpidovskaya , O. V. (2024). A Case of Keratinizing Squamous Cell Carcinoma of the Lung with Myocardial Carcinomatosis. Voprosy Onkologii, 70(1), 123–126. https://doi.org/10.37469/0507-3758-2024-70-1-123-126

Abstract

Introduction. Lung cancer is a common malignant neoplasm and it holds the top positions among the deadliest cancers. A prolonged absence of clinical symptoms results in a delay in seeking medical assistance. Given the pertinence of this issue, we present a case involving keratinizing squamous cell carcinoma of the lung with myocardial carcinomatosis.

Case description. A 65-year-old patient, who passed away at home, was brought in for a pathoanatomical autopsy. During the autopsy, a region with a cuff-like peribronchial tumor growth was found in the lower lobe bronchus of the right lung. Histological examination revealed tumor areas with indistinct stratification of cells. Keratinizing elements with pyknotic nuclei and abundant acidophilic cytoplasm were noted in the invasion zone. Clusters of atypical cells were found in the myocardium. An parietal tumor thrombus was noted in the right atrium. Histologically, there were signs of acute cardiovascular failure and cardiac tamponade.

Conclusion. The identified lung cancer in the lower lobe bronchus of the right lung (histological variant: poorly differentiated keratinizing squamous cell carcinoma) was characterized by the absence of characteristic metastases to lymph nodes. Myocardial carcinomatosis was observed.

https://doi.org/10.37469/0507-3758-2024-70-1-123-126
pdf (Русский)

References

Проскурня С.А., Совгиря С.Н., Филенко Б.Н., Ройко Н.В. Особенности пролиферативной активности высоко- и низкодифференцированного плоскоклеточного рака легкого. СМБ. 2017;3(61) [Proskurnya SA, Sovhyria SM, Filenko BN, Royko NV. Features of the proliferative activity of well differentiated and poorly differentiated squamous cell lung cancer. World of Medicine and Biology. 2017;3(61) (In Russ.)]. http://dx.doi.org/10.26724/2079-8334-2017-3-61-59-63.

Филенко Б.Н., Ройко Н.В., Проскурня С.А. Клинико-морфологические прогностические критерии высокодифференцированного плоскоклеточного рака легкого центральной локализации. Актуальні проблеми сучасної медицини. Вісник української медичної стоматологічної академії. 2017;2(58) [Filenko BN, Royko NV, Proskurnya SA. Clinical and morphological prognostic criteria for highly differentiated central lung squamous cell carcinoma. Actual Problems of the Modern Medicine: Bulletin of Ukrainian Medical Stomatological Academy. 2017;2(58) (In Russ.)]. [cited 2023 May 5] Available from: https://cyberleninka.ru/article/n/kliniko-morfologicheskie-prognosticheskie-kriterii-vysokodifferentsirovannogo-ploskokletochnogo-raka-legkogo-tsentralnoy.

Stellman SD, Takezaki T, Wang L, et al. Smoking and lung cancer risk in American and Japanese men: an international case-control study. Cancer Epidemiol Biomarkers Prev. 2001;10(11):1193-9.

Goldberg AD, Blankstein R, Padera RF. Tumors metastatic to the heart. Circulation. 2013;128(16):1790-4. http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000790.

Конради Ю.В., Рыжкова Д.В. Лучевая диагностика опухолей сердца. Трансляционная медицина. 2015;2(4):28-40 [Konradi YV, Ryzhkova DV. Cardiac tumors imaging. Translational Medicine. 2015;2(4):28-40 (In Russ.)].

Исаев Г.О., Миронова О.Ю., Юдакова М.Е., и др. Метастатическое поражение правого предсердия почечно-клеточной карциномой. Терапевтический архив. 2019;91(9):124-128 [Isaev GO, Mironova OY, Yudakova ME, et al. Metastatic lesion of the right atrium with renal cell carcinoma. Terapevticheskii arkhiv. 2019;91(9):124-8 (In Russ.)]. http://dx.doi.org/10.26442/00403660.2019.09.000218.

Имянитов Е.Н., Хансон К.П. Молекулярная онкология: клинические аспекты. Санкт-Петербург: Издательский дом СПбМАПО. 2007;213 [Imyanitov EN, Hanson KP. Molecular oncology: clinical aspects. St. Petersburg: SPbMAPO Publishing House. 2007;213 (In Russ.)].

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74. http://dx.doi.org/10.1016/j.cell.2011.02.013.

Сакович В.А., Гринштейн Ю.И., Дробот Д.Б., Вершинин И.Н. Клинико-морфологическая характеристика вторичного метастатического поражения сердца и перикарда. Сибирское медицинское обозрение. 2004:2-3 [Sakovich VA, Grinshtein YuI, Drobot DB, Vershinin IN. Clinical and morphological characteristics of secondary metastatic lesions of the heart and pericardium. Siberian Medical Review. 2004:2-3 (In Russ.)]. [cited 2023 May 5] Available from: https://cyberleninka.ru/article/n/kliniko-morfologicheskaya-harakteristika-vtorichnogo-metastaticheskogo-porazheniya-serdtsa-i-perikarda.

Воробьева О.В. Клинический случай аденокарциномы легкого с генерализованными метастазами во внутренние органы. Современная онкология. 2021;23(3):525-528 [Vorobeva OV. Clinical and morphological case of lung cancer with generalized metastases to the internal organs. Journal of Modern Oncology. 2021;23(3):525-8 (In Russ.)]. http://dx.doi.org/10.26442/18151434.2021.3.200856.

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