Влияние метформина на доксорубицин-индуцированную кардиотоксичность в эксперименте. Систематический обзор
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Ключевые слова

доксорубицин
метформин
кардиотоксичность
окислительный стресс
активные формы кислорода

Аннотация

В статье представлен обзор известных на сегодняшний день описаний механизмов действия и токсических эффектов двух препаратов: доксорубицина, препарата первой линии для лечения онкологических заболеваний, и метформина-препарата, широко применяемого для лечения сахарного диабета 2-го типа. С использованием систем NCBI, PubMed и OxfordAcademic представлен анализ опубликованных данных по протективному эффекту метформина при его сочетанном применении с доксорубицином в эксперименте при попытке снизить проявления доксорубицин-индуцированной кардиотоксичности.

https://doi.org/10.37469/0507-3758-2021-67-1-35-39
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