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Аннотация
Дополнительные молочные железы развиваются в результате неполной регрессии эмбриональных молочных линий не только у женщин, но и у мужчин, располагаются преимущественно в подмышечной впадине. Эти железы могут не иметь внешних проявлений (наличие соска и ареолы). Симптоматически проявляются циклическими болями и отеком во время менструации и беременности, обусловленными гормональными перестройками. Дополнительные молочные железы могут претерпевать и доброкачественные, и злокачественные патологические изменения, также как обычные анатомические молочные железы. В связи с низкой частотой встречаемости дополнительной молочной железы (у 2–6 % женщин) и ее патологических изменений, большая часть мировой литературы включает описания отдельных клинических случаев. Поэтому цель настоящего обзора: рассмотреть структуру, нормальный морфогенез и патологические изменения дополнительной молочной железы. Для подготовки обзора проведен поиск литературы по базам данных Scopus, Web of Science, Medline, PubMed, CyberLeninka, РИНЦ и CNKI. При анализе использованы отечественные и зарубежные научные и клинические исследования, индексируемые в базах данных Scopus, Web of Science, PubMed, из них 31 % опубликованны за последние 5 лет. Использовано 72 источника для написания данного литературного обзора.
Библиографические ссылки
Evans DM, Guyton DP. Carcinoma of the axillary breast. Journal of surgical oncology. 1995;59(3):190-195. https://doi.org/10.1002/jso.2930590311.
Cheong JH, Lee BC, Lee KS. Carcinoma of the axillary breast. Yonsei medical journal. 1999;40(3):290-293. https://doi.org/10.3349/ymj.1999.40.3.290.
Marshall MB, Moynihan JJ, Frost A, et al. Ectopic breast cancer: case report and literature review. Surgical oncology. 1994;3(5):295-304. https://doi.org/10.1016/0960-7404(94)90032-9
Константинова АМ, Белоусова ИЭ, Кацеровская Д, и др. Аногенитальные маммароподобные железы и связанные с ними заболевания. Часть 1. Доброкачественные опухоли и опухолеподобные процессы аногенитальных желез. Архив патологии. 2017;79(1):43-51 [Konstantinova AM, Belousova IE, Kacerovska D, et al. Anogenital mammary-like glands and related lesions. Part 1. Benign tumors and tumor-like disorders. Arkh Patol. 2017;79(1):43-51 (In Russ.)]. https://doi.org/10.17116/patol201779143-51.
Константинова АМ, Белоусова ИЭ, Кацеровская Д, и др. Морфология аногенитальных маммаро-подобных желез. Вестник Санкт-Петебургского университета. Медицина. 2017;12(1):83-92 [Konstantinova AM, Belousova IE, Kacerovska D, et al. Morphology of anogenital mammary-like glands. Vestnik SPbSU. Medicine. 2017;12(1);83-92 (In Russ.)]. https://doi.org/10.21638/11701/spbu11.2017.107.
Kazakov DV, McKee PH, Michal M, et al. Cutaneous Adnexal Tumors. Philadelphia: Lippincott Williams & Wilkins (LWW). 2012:830.
Gutermuth J, Audring H, Voit C, et al. Primary carcinoma of ectopic axillary breast tissue. J Eur Acad Dermatol Venereol. 2006;20(2):217-221. https://doi.org/10.1111/j.1468-3083.2005.01362.x.
Lim SY, Jee SL, Gee T, et al. Axillary accessory breast carcinoma masquerading as axillary abscess: a case report. Med J Malaysia. 2016;71(6):370-371.
Khan RN, Parvaiz MA, Khan AI, et al. Invasive carcinoma in accessory axillary breast tissue: A case report. Int J Surg Case Rep. 2019;59:152-155. https://doi.org/10.1016/j.ijscr.2019.05.037.
Koltuksuz U, Aydin E. Supernumerary breast tissue: a case of pseudomamma on the face. J Pediatr Surg. 1997;32(9):1377-8. https://doi.org/10.1016/s0022-3468(97)90327-4.
Conde DM, Kashimoto E, Torresan RZ, et al. Pseudomamma on the foot: an unusual presentation of supernumerary breast tissue. Dermatol Online J. 2006;12(4):7.
Shreshtha S. Supernumerary Breast on the Back: a Case Report. Indian J Surg. 2016;78(2):155-7. https://doi.org/10.1007/s12262-016-1443-8.
Godoy-Gijón E, Yuste-Chaves M, Santos-Briz A, et al. Mama ectópica vulvar [Accessory breast on the vulva (Span.)]. Actas Dermosifiliogr. 2012;103(3):229-32. https://doi.org/10.1016/j.ad.2011.02.015.
Loukas M, Clarke P, Tubbs RS. Accessory breasts: a historical and current perspective. Am Surg. 2007;73(5):525-8.
Friedman-Eldar O, Melnikau S, Tjendra Y, et al. Axillary reverse lymphatic mapping in the treatment of axillary accessory breast cancer: a case report and review of management. Eur J Breast Health. 2021;18(1):1-5. https://doi.org/10.4274/ejbh.galenos.2021.2021-7-3.
Madej B, Balak B, Winkler I, et al. Cancer of the accessory breast--a case report. Adv Med Sci. 2009;54(2):308-10. https://doi.org/10.2478/v10039-009-0031-6.
Francone E, Nathan MJ, Murelli F, et al. Ectopic breast cancer: case report and review of the literature. Aesthetic Plast Surg. 2013;37(4):746-9. https://doi.org/10.1007/s00266-013-0125-1.
Fu NY, Nolan E, Lindeman GJ, et al. Stem cells and the differentiation hierarchy in mammary gland development. Physiol Rev. 2020;100(2):489-523. https://doi.org/10.1152/physrev.00040.2018.
Spina E, Cowin P. Embryonic mammary gland development. Semin Cell Dev Biol. 2021;114:83-92. https://doi.org/10.1016/j.semcdb.2020.12.012.
Chen W, Wei W, Yu L, et al. Mammary development and breast cancer: a notch perspective. J Mammary Gland Biol Neoplasia. 2021;26(3):309-320. https://doi.org/10.1007/s10911-021-09496-1.
Slepicka PF, Somasundara AVH, Dos Santos CO. The molecular basis of mammary gland development and epithelial differentiation. Semin Cell Dev Biol. 2021;114:93-112. https://doi.org/10.1016/j.semcdb.2020.09.014.
Мнихович МВ, Безуглова ТВ, Буньков КВ, и др. Роль эпителиально-мезенхимального перехода в формировании метастатического потенциала злокачественной опухоли на примере рака молочной железы. Вопросы онкологии. 2022;3:251-259 [Mnikhovich MV, Bezuglova TV, Bunkov KV, et al. Role epithelial – mesenchymal transition in formation of metastatic potential of a malignant tumor on the example of a breast cancer. Voprosy Onkologii. 2022;68(3):251-9 (In Russ.)]. https://doi.org/10.37469/0507-3758-2022-68-3-251-259.
Yin P, Wang W, Zhang Z, et al. Wnt signaling in human and mouse breast cancer: Focusing on Wnt ligands, receptors and antagonists. Cancer Sci. 2018;109(11):3368-3375. https://doi.org/10.1111/cas.13771.
Porter JC. Proceedings: Hormonal regulation of breast development and activity. J Invest Dermatol. 1974;63(1):85-92. https://doi.org/10.1111/1523-1747.ep12678099.
Hughes ES. The development of the mammary gland: arris and gale lecture, delivered at the Royal College of Surgeons of England on 25th October, 1949. Ann R Coll Surg Engl. 1950;6(2):99-119.
Schultz A. Pathologische Anatomie der Brustdrüse. Weibliche Geschlechtsorgane. 1933;1-208. https://doi.org/10.1007/978-3-7091-5372-7_1.
Thasanabanchong P, Vongsaisuwon M. Unexpected presentation of accessory breast cancer presenting as a subcutaneous mass at costal ridge: a case report. Journal of Medical Case Reports. 2020;14(1). http://dx.doi.org/10.1186/s13256-020-02366-0.
Halleland HH, Balling E, Tei T, et al. Polythelia in a 13-year old girl. G Chir. 2017;38(3):143-146. http://dx.doi.org/10.11138/gchir/2017.38.3.143.
Pfeifer JD, Barr RJ, Wick MR. Ectopic breast tissue and breast-like sweat gland metaplasias: an overlapping spectrum of lesions. Journal of Cutaneous Pathology. 1999;26(4):190-6. http://dx.doi.org/10.1111/j.1600-0560.1999.tb01827.x
Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2003;68:771-8. https://doi.org/10.1016/S0039-128X(03)00126-0.
Dimitrakakis C, Bondy C. Androgens and the breast. Breast Cancer Research. 2009;11(5). http://dx.doi.org/10.1186/bcr2413.
Nicolás Díaz-Chico B, Germán Rodríguez F, González A, et al. Androgens and androgen receptors in breast cancer. J Steroid Biochem Mol Biol. 2007;105(1-5):1-15. https://doi.org/10.1016/j.jsbmb.2006.11.019.
Ogawa Y, Hai E, Matsumoto K, et al. Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. Int J Clin Oncol. 2008;13(5):431-5. https://doi.org/10.1007/s10147-008-0770-6.
Timmermans-Sprang EPM, Gracanin A, Mol JA. Molecular signaling of progesterone, growth hormone, wnt, and HER in mammary glands of dogs, rodents, and humans: new treatment target identification. Frontiers in Veterinary Science. 2017;4. http://dx.doi.org/10.3389/fvets.2017.00053.
Chung HH, Or YZ, Shrestha S, et al. Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution. Sci Rep. 2017;7:46485. https://doi.org/10.1038/srep46485.
Wong CW, McNally C, Nickbarg E, et al. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci U S A. 2002;99(23):14783-8. https://doi.org/10.1073/pnas.192569699.
Aupperlee MD, Zhao Y, Tan YS, et al. Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland. Endocrinology. 2014;155(6):2301-13. https://doi.org/10.1210/en.2013-1933.
Cinpolat A, Bektas G, Seyhan T, et al. Treatment of a supernumerary large breast with medial pedicle reduction mammaplasty. Aesth Plast Surg. 2013;37:762-766. https://doi.org/10.1007/s00266-013-0129-x.
Azoz M, Abdalla A, Elhassan M. Fibroadenoma in ectopic breast tissue: a case report. Sudan Med J. 2014;50(2):112-5.
Dzodic R, Stanojevic B, Saenko V, et al. Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. Diagn Pathol. 2010;5:17. https://doi.org/10.1186/1746-1596-5-17.
Lim SY, Jee SL, Gee T, et al. Axillary accessory breast carcinoma masquerading as axillary abscess: a case report. Med J Malaysia. 2016;71(6):370-371.
Arora BK, Arora R, Aora A, et al. Axillary accessory breast: presentation and treatment. Int Surg J. 2016;3:2050-3. https://doi.org/10.18203/2349-2902.ISJ20163571.
Gajaria PK, Maheshwari UM. Fibroadenoma in axillary ectopic breast tissue mimicking lymphadenopathy. J Clin Diagn Res. 2017;11(3):ED01-ED02. https://doi.org/10.7860/JCDR/2017/23295.9358.
Goyal S, Sangwan S, Singh P, et al. Fibroadenoma of axillary ectopic breast tissue: a rare clinical entity. Clin Cancer Investig J. 2014;3(3):242. https://doi.org/10.4103/2278-0513.132120.
Lee SR, Lee SG, Byun GY, et al. Axillary accessory breast: optimal time for operation. Aesthetic Plast Surg. 2018;42:1231-1243. https://doi.org/10.1007/s00266-018-1128-8.
Yefter ET, Shibiru YA. Fibroadenoma in axillary accessory breast tissue: a case report. J Med Case Rep. 2022;16(1):341. https://doi.org/10.1186/s13256-022-03540-2.
Lee SR. Surgery for fibroadenoma arising from axillary accessory breast. Womens Health. 2021;21(1):139. https://doi.org/10.1186/s12905-021-01278-5.
Salemis NS, Gemenetzis G, Karagkiouzis G, et al. Tubular adenoma of the breast: a rare presentation and review of the literature. J Clin Med Res. 2012;4(1):64-7. https://doi.org/10.4021/jocmr746w.
Irshad A, Ackerman SJ, Pope TL, et al. Rare breast lesions: correlation of imaging and histologic features with WHO classification. Radiographics. 2008;28(5):1399-414. https://doi.org/10.1148/rg.285075743.
Hertel BF, Zaloudek C, Kempson RL. Breast adenomas. Cancer. 1976;37(6):2891-905. https://doi.org/10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p.
Eguchi Y, Yoshinaka H, Hayashi N, et al. Accessory breast cancer in the inframammary region: a case report and review of the literature. Surg Case Rep. 2021;7(1):203. https://doi.org/10.1186/s40792-021-01285-6.
Friedman-Eldar O, Melnikau S, Tjendra Y, et al. Axillary reverse lymphatic mapping in the treatment of axillary accessory breast cancer: a case report and review of management. European Journal of Breast Health. 2022;18(1):1-5. http://dx.doi.org/10.4274/ejbh.galenos.2021.2021-7-3.
Nihon-Yanagi Y, Ueda T, Kameda N, et al. A case of ectopic breast cancer with a literature review. Surg Oncol. 2011;20(1):35-42. http://dx.doi.org/10.1016/j.suronc.2009.09.005.
Marshall MB, Moynihan JJ, Frost A, et al. Ectopic breast cancer: case report and literature review. Surg Oncol. 1994;3(5):295-304. http://dx.doi.org/10.1016/0960-7404(94)90032-9.
Salemis N.S. Primary ectopic breast carcinoma in the axilla: a rare presentation and review of the literature. Breast Dis. 2021;40(2):109-114. https://doi.org/10.3233/BD-201027.
Mazine K, Bouassria A, Elbouhaddouti H. Bilateral supernumerary axillary breasts: a case report. Pan Afr Med J. 2020;36:282. https://doi.org/10.11604/pamj.2020.36.282.20445.
Francone E, Nathan MJ, Murelli F, et al. Ectopic breast cancer: case report and review of the literature. Aesthetic Plast Surg. 2013;37(4):746-9. https://doi.org/10.1007/s00266-013-0125-1.
du Toit RS, Locker AP, Ellis IO, et al. Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes. Br J Cancer. 1989;60(4):605-9. https://doi.org/10.1038/bjc.1989.323.
Mandal S, Bethala MG, Dadeboyina C, et al. A rare presentation of an invasive ductal carcinoma of ectopic axillary breast tissue. Cureus. 2020;12(8):e9928. https://doi.org/10.7759/cureus.9928.
Friedman-Eldar O, Melnikau S, Tjendra Y, et al. Axillary reverse lymphatic mapping in the treatment of axillary accessory breast cancer: a case report and review of management. J Breast Health. 2021;18(1):1-5. https://doi.org/10.4274/ejbh.galenos.2021.2021-7-3.
Lim SY, Jee SL, Gee T, et al. Axillary accessory breast carcinoma masquerading as axillary abscess: a case report. Med J Malaysia. 2016;71(6):370-371.
Khan RN, Parvaiz MA, Khan AI, et al. Invasive carcinoma in accessory axillary breast tissue: A case report. Int J Surg Case Rep. 2019;59:152-155. https://doi.org/10.1016/j.ijscr.2019.05.037.
Nguyen TH, El-Helou E, Pop CF, et al. Primary invasive ductal carcinoma of axillary accessory breast. Int J Surg Case Rep. 2022;98:107597. https://doi.org/10.1016/j.ijscr.2022.107597.
Litière S, Werutsky G, Fentiman IS, et al. Breast conserving therapy versus mastectomy for stage I-II breast cancer: 20 year follow-up of the EORTC 10801 phase 3 randomised trial. Lancet Oncol. 2012;13(4):412-9. https://doi.org/10.1016/S1470-2045(12)70042-6.
Chung-Park M, Zheng Liu C, Giampoli EJ, et al. Mucinous adenocarcinoma of ectopic breast tissue of the vulva. Arch Pathol Lab Med. 2002;126(10):1216-8. https://doi.org/10.5858/2002-126-1216-MAOEBT.
Pang L, Cui M, Dai W, et al. Diagnosis and treatment of male accessory breast cancer: a comprehensive systematic review. Front Oncol. 2021;11:640000. https://doi.org/10.3389/fonc.2021.640000.
Vishnubalaji R, Alajez NM. Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling. Sci Rep. 2021;11(1):15410. https://doi.org/10.1038/s41598-021-94514-9.
Guo Q, Betts C, Pennock N, et al. Mammary gland involution provides a unique model to study the TGF-β cancer paradox. J Clin Med. 2017;6(1):10. https://doi.org/10.3390/jcm6010010.
Taylor MA, Lee YH, Schiemann WP. Role of TGF-β and the tumor microenvironment during mammary tumorigenesis. Gene Expr. 2011;15(3):117-32. https://doi.org/10.3727/105221611x13176664479322.
Wang S, Su X, Xu M, et al. Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway. Stem Cell Res Ther. 2019;10(1):117. https://doi.org/10.1186/s13287-019-1220-2.
Takahashi E, Terata K, Nanjo H, et al. A male with primary accessory breast carcinoma in an axilla is strongly suspected of having hereditary breast cancer. Int Cancer Conf J. 2021;10(2):107-111. https://doi.org/10.1007/s13691-020-00466-8.
Imyanitov, E.N. Cytotoxic and targeted therapy for BRCA1/2-driven cancers. Hered Cancer Clin Pract. 2021;19(36). https://doi.org/10.1186/s13053-021-00193-y.
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