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Abstract
Aim. To study the effect of the thyrostatic drug propylthiouracil (PTU) on the life expectancy of rats with C6 glioma.
Materials and Methods. In vivo brain tumor modeling was performed using intracerebral stereotaxic implantation of C6 glioma cells into rats (n = 32). Animals were randomized into two groups with 9:7 ratio. Rats of the experimental group (n = 18) were modeled hypothyroidism by oral probe (gavage) administration of propylthiouracil 15 μL per animal once a day.
Results. PTU administration significantly (χ2 = 16.91; p = 0.001) by 63.16 % increases the life expectancy of rats (n = 18; 16.0 ± 2.37 days) compared to control (n = 14; 10.0 ± 4.2 days) and reduces the risk of death (HR = 0.14; 0.05-0.38).
Conclusion. PTU administration increases the life expectancy of rats with C6 glioma and reduces the risk of death.
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