VARIANTS OF METABOLIC SYNDROME OF THE PATIENTS WITH COLORECTAL CANCER: A RELATIONSHIP WITH CLINICAL AND MORPHOLOGICAL PARAMETERS

Abstract

The objective is to study the incidence of metabolic syndrome (MS) and overweight in patients with colorectal cancer as well as to evaluate the relationship with clinical and morphological features and to analyze the incidence of 3-, 4- and 5- components МS in patients with colorectal cancer.

Materials and methods. The investigation involved 99 people with the prevalence of the tumor process T2-3N1-2M1. Depending on the presence of MS or overweight patients were divided into 3 groups. The recommendations of the International Diabetes Federation (2005) were used for inclusion in the group with MS. Statistical processing of the results was made with the Statistica 10.0 software package.

Results. About 78% of patients with colorectal cancer had metabolic disorders: 67% had MS, 11% had overweight. The patients with colorectal cancer had mainly the 3- and 4-components variants of MS (46% and 47%, respectively), the 5 components MS occurred in 7% of cases. No significant relationship was found between the presence/absence of the MS, and MS variant and age, sex, stage, and localization of the tumor process. A significant correlation was revealed between the presence of MS/ MS variants and tumor Grade. In particular, G3 adenocarcinomas meet more often in the presence of MS5. An association of MS and its individual components was identified with recurrence- free / overall survival, in particular, the presence of MS, an increase in body mass index, waist size, and the presence of diabetes mellitus type II is associated with a decrease in recurrence-free survival. Increased blood triglyceride levels are associated with a decrease in overall survival.