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Abstract
An analysis of economic and logistical problems of radiation oncology is presented based on domestic and foreign literature. Despite the high efficacy of radiotherapy this branch of oncology is not financed enough in the most countries. As a consequence, it is ubiquitously marked radiotherapy capacity deficit that does not allow to fully realize its therapeutic potential. Medical electron accelerators and related equipment have become increasingly complex and expensive and radiotherapy techniques more consuming. Even in developed countries there have become a daily reality growing waiting times for radiation therapy, avoiding the use of the most modern and efficient technologies for radiation therapy (radiotherapy under visual control , etc.). Based on these data, there is evaluated the prospects and possibilities of upgrading of the technical base of radiation oncology in Russia including the development of hadron therapy.References
Давыдов М.И., Голанов А.В., Канаев С.В. и соавт. Анализ состояния и концепция модернизации радиационной онкологии, ядерной медицины и медицинской физики в России (краткое изложение) // Мед. физика. - 2013. - № 2 (58). - С. 8-19.
Ефимкина Ю.В., Гладилина И.А., Нечушкин М.И. и соавт., Гипофракционированные режимы лучевой терапии после органосохраняющих операций по поводу рака молочной железы I-IIa стадий // Опухоли женской репродуктивной системы. - 2011. - № 3. - С. 45-53.
Измайлов Т.Р., Паньшин Г.А., Даценко П.В. Роль функционального состояния и классов RPA в выборе режима фракционирования при лечении глиом высокой степени злокачественности // Вопр. онкол. - 2012. - Т. 58. - № 3. - С. 369-374.
Ильин М.А., Сотников В.М., Паньшин Г.А. и соавт. Четырехлетние результаты лучевой терапии средними фракциями периферического немелкоклеточного рака легкого // Мед. радиология и рад. безопасность. - 2010. - Т. 55. - № 5. - С. 35-41.
Каприн А.Д., Старинский В.В., Петрова Г.В. (ред). Злокачественные новообразования в России в 2012 г.- М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России. - 2014. - 250 с.
Костылев В.А. Азбука и арифметика системной модернизации радиационной онкологии // Мед. физика. - 2010. - № 1 (45). - С. 5-23.
Мардынский Ю.С., Гулидов И.А., Золотков А.Г. и соавт. Ускоренные режимы лучевой терапии рака легкого // Радиацион. онкол. и ядерная мед. 2011. - № 1. - С. 14-17.
Чиссов В.И., Старинский В.В., Петрова Г.В. (ред.) Состояние онкологической помощи населению России в 2010 году. М.: ФГУ «МНИОИ им. П.А. Герцена Росмедтехнологий». - 2011. - 196 с.
Allen A.M., Pawlicki T., Dong L. et al. An evidence based review of proton beam therapy: The report of ASTRO’s emerging technology committee // Radiother. Oncol. - 2012. - Vol.103. - № 1. - P. 8-11.
Ballas L.K., Elkin E.B., Schrag D. Radiation Therapy Facilities in the United States // Int. J. Radiat. Oncol. Biol. Phys. - 2006. - Vol. 66. - No. 4. - P 1204-1211.
Barton M.B., Manderson C., Gebski V. et al. Does waiting time affect the outcome of larynx cancer treated by radiotherapy? // Radiother. Oncol. - 1997. - Vol. 44 - Iss. 2. - P. 137-141.
Barton M.B., Gebski V., Manderson C. and Langlands A.O. Radiation Therapy: Are We Getting Value for Money? // Clin. Oncol. - 1995. - Vol. 7. - P. 287-292.
Baumann M., Herrmann T., Koch R. et al., Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC) // Radiother. Oncol. - 2011. - Vol. 100. - № 1. - P. 76-85.
Bentzen S.M. High-tech in radiation oncology: should there be a ceiling? // Int. J. Radiat. Oncol. Biol. Phys. - 2004. - Vol. 58. - Iss. 2. - P. 320-330.
Bentzen S.M., Herren G., Cottier B. et al. Towards evidence-based guidelines for radiotherapy infrastructure and staffing needs in Europe: ESTRO QUARTS Project // Radiother. Oncol. - 2005. - Vol. 75. - Iss. 3. - P. 355-365.
Bijdekerke P., Verellen D., Tournel K. et al. Tomo Therapy: implications on daily workload and scheduling patients // Radiother. Oncol. - 2008. - Vol. 86. - Iss. 2. - P. 224-230.
Bissonnette J-P., Blackburn H., Marshall А. et al. A Pilot Study on Reducing Radiation Therapy Planning Timelines // Radiother. Oncol. - 2006. - Vol. 80. - S.1. - A.45.
Chang D., Xia T., Li P. et al. Promising Clinical Outcome of Stereotactic Body Radiation Therapy for Limited Pancreatic Carcinoma. Proceedings of the 52nd Annual ASTRO Meeting // Int. J. Radiat. Oncol. Biol. Phys. - 2010. - Vol. 78. - № 3. - Supp. A. 2230.
Cox J.D. Passing the Baton-in a Maraphon // Int. J. Radiat. Oncol. Biol. Phys. - 2011. - Vol. 81. - № 5. - P. 1206-1207.
Coyle D., Drummond M.F. Costs of Conventional Radical Radiotherapy Versus Continuous Hyperfractionated Accelerated Radiotherapy (CHART) in the Treatment of Patients with Head and Neck Cancer or Carcinoma of the Bronchus // Clin. Oncol. - 1997. - Vol. 9. - № 3. - P. 313-321.
Delaney G., Jacob S., Featherstone C. et al. Estimating the Optimal Radiotherapy Utilisation Rate Based on Clinical guidelines and Best Available Evidence and Comparing it to Current Practice // R adiother. Oncol. - 2006. - Vol. 80. - S.1. - A.5.
Delaney G.P., Gebski V., Lunn A.D. et al. An Assessment of the Basic Treatment Equivalent (BTE) Model as Measure of Radiotherapy Workload // Clin. Oncol. - 1997. - Vol. 9. - № 2. - P. 240-244.
Delaney G., Shafig R., Jalaludin S. et al. Technology Enhancements and Changes in Radiotherapy Throughput in New South Wales // Radiother. Oncol. - 2006. - Vol. 80. - S.1. - A. 44.
van der Giessen P.-H., Alert J., Badri C. et al. Multinational assessment of some operational costs of teletherapy // Radiother. Oncol. - 2004. - Vol. 71. - № 3. - P. 347-355.
Goitein M., Jermann M. The relative cost of proton and X-ray radiation therapy // Clin. Oncol. - 2003. - Vol. 15. - Suppl. - P. 37-50.
Griffiths S. Managers survey. London: College of Radiographers, 2004. 61.
Hoskin P.J., Rojas A.M., Bownes P.J. et al. Randomised trial of external beam radiotherapy alone or combined with high-dose-rate brachytherapy boost for localised prostate cancer // Radiother. Oncol. - 2012. - Vol. 103. - № 2. - P. 217-222.
Hulshof M.C., Schimmel E.C., Bosch D.A. et al. Hypofractionation in glioblastoma multiforme // Radiother. Oncol. - 2000. - Vol. 54. - Iss.2. - P 143-148.
James N., Daniels H., Rahman R. et al. A study of information seeking by cancer patients and their carers // Clin Oncol. - 2007. - Vol. 19. - P. 356-362.
Jones B., Price P. Proton therapy: expanding clynical indications // Clin. Oncol. - 2004. - Vol. 16. - № 5. - P. 324-325.
Kesteloot K., Lievens Y., van der Schueren E. Improved management of radiotherapy departments through accurate cost data // Radiother. Oncol. - 2000. - Vol.55. - № 2. - Р. 251-262.
Konski A., James J., Hartsell W. et al. Economic analysis of radiation therapy oncology group 97-14: multiple versus single fraction radiation treatment of patients with bone metastases // Am. J. Clin. Oncol. - 2009. - Vol. 32. - № 4. - P. 423-428.
Konski A. Radiotherapy is a cost-effective palliative treatment for patients with bone metastasis from prostate cancer // Int. J. Radiat. Oncol. Biol. Phys. - 2004. - Vol. 60. - № 5. - P. 1373-1378.
Langendijk J.A., Lambin P., De Ruysscher D. et al. Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach // Radiother. Oncol. - 2013. - Vol. 107. - № 2. - P. 267-273.
Laukkanen E. Radiation Waiting Times - The Tip of the Iceberg // Radiother. Oncol. - 2006. - Vol. 80. - S.1. - A. 47.
Lim K., Vinod S.K., Bull C. et al. Prioritization of radiotherapy in Australia and New Zealand // Australias Radiol. - 2005. - Vol. 49. - P. 485-488.
Lievens Y., Van den Bogaert. Proton beam therapy: Too expensive to become true // Radiother. Oncol. - 2005. - Vol. 75. - № 2. - Pol. 131-133.
Lievens Y., Cai Grau. Health Economics in Radiation Oncology: Introducing the ESTRO HERO project // Radiother. Oncol. - 2012. - Vol. 103. - № 1. - P. 109-112.
Ling C.C., Yorke Y., Zvi Fuks. From IMRT to IGRT: Frontierland or Neverland // Radiother. Oncol. - 2006. - Vol. 78. - Iss. 2. - P. 119-122.
Leer J.W.H. The future development of radiation oncology in Europe // Radiother. Oncol. - 2011. - Vol. 100. - № 1. - P. 7-9.
Lutz S., Berk L., Chang E. et al. Palliative Radiotherapy for Bone Metastases: an ASTRO Evidence-Based Guideline // Int. J. Radiat. Oncol. Biol. Phys. - 2011. - Vol. 79. - No. 4. - P. 965-976.
Macdonald O.K., Kruse J.J., Miller J.M. Proton Beam Radiotherapy versus Three-dimentional Comforml Stereotactic Body Radiotherapy in Primary Peripheral, Early-Stage Non-Small-Cell Lung Carcinoma: a Comparative Dosimetrical Analysis // Int. J. Radiat. Oncol. Biol. Phys. - 2009. - Vol. 75. - No. 3. - P. 950-958.
Meyer H.J. Expensive new therapy and finite resouses: An ethical dilemma for doctors and scientists // Radiother. Oncol. - 2006. - Vol. 1. - Iss. 3. - P. 227-230.
Munro A.J. The Costs of Hyperfractionation: An Economic Analysis Incorporating Consideration of Waiting Time for Treatment // Clin. Oncol. - 1995. - Vol. 7. - № 2. - P. 162-167.
Nieder C., Pawinski A., Haukland E. et al. Estimating Need for Palliative External Beam Radiotherapy in Adalt Cancer Patients // Int. J. Radiat. Oncol. Biol. Phys. - 2010. - Vol. 76. - № 1. - P. 207-211.
Peeters A., Grutters J.P.C., Pijls-Johannesma M. et al. How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons // Radiother. Oncol. - 2010. - Vol. 95. - № 1. - P. 45-53.
Perrier L., Morelle M., Pommier P. et al. Cost of prostate image-guided radiation therapy: Results of a randomized trial // Radiother. Oncol. - 2013. - Vol. 106. - № I. - P. 50-58.
Platanionis G.A., Dale R.G. Biologically Effective Dose-Response Relationship for Breast Cancer Treated by Conservative Sugery and Postoperative Radiotherapy // Int. J. Radiat. Oncol. Biol. Phys. - 2009. - Vol. 75. - No. 2. - P. 512-517.
Ploquin N.P., Dunscombe P.B. The cost of radiation therapy // Radiother. Oncol. - 2008. - Vol. 86. - № 2. - P. 217-223.
Ploquin N.P., Dunscombe P.B. A cost-outcome analysis of Image-Guided Patient Repositioning in the radiation treatment of cancer of the prostate // Radiother. Oncol. - 2009. - Vol. 93. - № 1. - P. 25-31.
Poon I., Pintilie M., Potvin M. et al. The changing cost of radiation treatment for early prostate cancer in Ontario: a comparison between conventional and conformal external beam radiotherapy // Can. J. Urol. - 2004. - Vol. II. - P. 2125-2132.
Potters L., Kavanach B., Galvin J.M. et al. American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) Practice Guidline for the Perfomance of Stereotactic Body Radiation Therapy // Int. J. Radiat. Oncol. Biol. Phys. - 2010. - Vol. 76. - № 2. - P. 326-332.
Probst H., Griffithsy S. Moving to a High-tech Approach to the Irradiation of Early Breast Cancer: Is It Possible to Balance Efficacy, Morbidity and Resource Use? // Clin Oncol. - 2006. - Vol. 18. - P. 268 - 275.
Robinson D., Massey T., Davies E. et al. Waiting times for radiotherapy: variation over time and between cancer networks in southeast England // Br. J. Cancer. - 2005. - Vol. 92. - P. 1201-1208.
Sergio Faria, Alan Dal Pra, Fabio Cury et al. Treating intermediate-risk prostate cancer with hypofractionated external beam radiotherapy alone // Radiother. Oncol. - 2011. - Vol. 101. - № 4. - P. 486-489.
Shafig J., Delaney G., Barton M.B. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer // Radiother. Oncol. - 2007. - Vol. 84. - № 1. - P. 11-17.
Shafer C., Nelson K., Herbst M. Warten auf eine Strahlen-therapy. Eine Aufforderung einen nationalen Diskus uber Wartelisten in der Radiotherapie zu fuhren: Ergebnisse einer Befragung // Strahlenther. Onkol. - 2005. - Vol. 181. - P. 9-19.
Showalter T.N., Foley K.A., Jutkowitz E. Costs of Early Adjuvant Radiation Therapy after Radical Prostatectomy: A Decision Analysis // Int. J. Radiat. Oncol. Biol. Phys. - 2010. - Vol. 78. - № 3. - Suppl. 1.
Sikora K., James N. Top-up Payments in Cancer Care // Clin Oncol. - 2009. - Vol. 21. - № 1. - P. 1-5.
Slotman B.J., Vos P.H. Planning of radiotherapy capacity and productivity // Radiother. Oncol. - 2013. - Vol. 106. - № 2. - P. 266-270.
Smith B.D., Pan I.W., Shih YC. et al. Adobtion of intensity-modulated radiation therapy for breast cancer in the United States // J. Natl. Cancer Inst. - 2011. - Vol. 103. - P. 798-809.
Sullivan R., Peppercorn J., Sikora K. et al. Delivering affordable cancer care in high-income countries // Lancet Oncol. - 2011. - Vol. 12. - P. 933-980.
Teruki Teshima, Hodaka Numasaki, Hitoshi Shibuya. Japanese Structure Survey of Radiation Oncology in 2007 Based on Institutional Stratification of Patterns of Care Study // Int. J. Radiat. Oncol. Biol. Phys. - 2010. - Vol. 78. - № 5. - P. 1483-1493.
Tyldesley S., Delaney G., Foroudi F. et al. Estimating the need for radiotherapy for patients with prostate breast, and lung cancers: verifications of model estimates of need with radiotherapy utilisation data from British Colambia // Int. J. Radiat. Oncol. Biol. Phys. - 2011. - Vol. 79. - № 5. - P. 1507-1515.
Uyl-de Groot C.A., Stupp R., van der Bent M. Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme // Expert Rev. Pharmacoecon. Outcomes Res. - 2009. - Vol. 9. - № 3. - P. 235-241.
Van de Werf E., Lievens Y., Verstraete J. et al. Time and motion study of radiotherapy delivery: Economic burden of increased quality assurance and IMRT // Radiother. Oncol. - 2009. - Vol. 93. - № 1. - P. 137-140.
Widesott L., Amichetti M., Schwarz M. Proton therapy in lung cancer: Clinical outcomes and technical issues. A systematic review // Radiother. Oncol. - 2008. - Vol. 86. - №. 2. - P. 154-164.
White L., Beckingham E., Calman F., Deehan C. Extended Hours Working in Radiotherapy in the UK // Clin. Oncol. - 2007. - Vol. 19. - P. 213-222.
Williams M.V., Jamesy N.D., Summers E.T. National Survey of Radiotherapy Fractionation Practice in 2003 // Clin. Oncol. - 2006. - Vol. 18. - № 1. - P. 3-14.
Williams M.V., Summers E.T., Drinkwater K., Barret A. Radiotherapy Dose Fractionation, Access and Waiting Times in the Countries of the UK in 2005 // Clin. Oncol. - 2007. - Vol. 19. - № 2. - P. 273-286.
Yoon Kim J.Y., Chul Seung Kay, Yeon Sil Kim et al. Helical Tomotherapy for Simultaneous Multytaget Radiotherapy for Pulmonary Metastasis // Int. J. Radiat. Oncol. Biol. Phys. - 2009. - Vol. 75. - No. 3. - P. 703-710.
Zheng Chen, W. King, R. Pearcey, et al. The relationship between waiting time for radiotherapy and clinical outcomes: a systematic review of the literature // Radiother. Oncol. - 2008. - Vol. 87. - № 1. - P. 3-16.
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