Research of topoisomerase IIa in conjunction with clinical and morphological parameters and proliferation (to identify argyrophilic proteins of nucleolar organizer regions and antigen ki-67) in lung adenocarcinoma
Vol. 69 No. 6 (2023), Articles
Vol. 69 No. 6 (2023)

Research of topoisomerase IIa in conjunction with clinical and morphological parameters and proliferation (to identify argyrophilic proteins of nucleolar organizer regions and antigen ki-67) in lung adenocarcinoma

Articles
https://doi.org/10.37469/0507-3758-2014-60-2-63-68
Published 15.12.2014
City Hospital, Kogalym
Altai Medical University
Altai branch of the N.N. Blokhin Russian Cancer Research Center
Altai branch of the N.N. Blokhin Russian Cancer Research Center
Altai branch of the N.N. Blokhin Russian Cancer Research Center
Research Institute of Regional Pathology and Pathomorphology
Research Institute of Regional Pathology and Pathomorphology
PDF (Русский)

Keywords

Ki-67
topoisomerase ІІα
argyrophilic proteins of nucleolar organizer regions
lung adenocarcinoma

How to Cite

, , , , , , & . (2014). Research of topoisomerase IIa in conjunction with clinical and morphological parameters and proliferation (to identify argyrophilic proteins of nucleolar organizer regions and antigen ki-67) in lung adenocarcinoma. Voprosy Onkologii, 69(6), 63–68. https://doi.org/10.37469/0507-3758-2014-60-2-63-68
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Abstract

Investigated topoisomerase ІІα (ТороІІα), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and antigen Ki-67 in lung adenocarcinoma. Defined tumor with low and high ТороІІа, Ag-NOR and Ki-67. ТороІІа had a relationship with clinical and morphological parameters (greatest dimension, tumor differentiation ) and proliferation markers (Ag-NOR, Ki-67) . Survival of patients with lung adenocarcinoma with low content of ТороІІα is better as compared with high content of ТороІІα. Survival of patients with lung adenocarcinoma depends on the mutual content of ТороІІα and clinical and morphological parameters (value T, greatest dimension, value N, stage, tumor differentiation), proliferation markers (Ag-NOR). ТороІІα content in lung adenocarcinoma is an independent prognostic factor. Mutual research of ТороІІα with clinical and morphological parameters and Ag-NOR has prognostic value in lung adenocarcinoma.
https://doi.org/10.37469/0507-3758-2014-60-2-63-68
PDF (Русский)

References

Beresford M.J., Wilson G.D., Makris A. Measuring proliferation in breast cancer: practicalities and applications // Breast Cancer Res. - 2006. - Vol. 8. - P. 216.

Canet V., Montmasson M.P., Usson Y. et al. Correlation between silver-stained nucleolar organizer region area and cell cycle time // Cytometry. - 2001. - Vol. 43. - P. 110-116.

Carvalho P.E., Antonangelo L., Bernardi F.D. et al. Useful prognostic panel markers to express the biological tumor status in resected lung adenocarcinomas // Jpn J Clin Oncol. - 2000. - Vol. 30. - P 478-486.

Derenzini M., Trere D. Standardization of interphase AgNOR measurement by means of an automated image analysis system using lymphocytes as an internal control // J Pathol. - 1991. - Vol. 165. - P. 337-342.

Derenzini M., Sirri V., Trere D., Ochs R. The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells // Lab invest. -1995. - Vol. 73. - P. 497-502.

Dingemans A.C., van Ark-Otte J., Span S. et al. Topoi-somerase Nalpha and other drug resistance markers in advanced non-small cell lung cancer // Lung Cancer. - 2001. - Vol. 32. - P. 117-128.

Erguden H.C., Koksal D., Demirag F. et al. The association of topoisomerase 2 expression with prognosis in surgically resected non-small cell lung cancer (NSCLC) patients // J Thorac Dis. - 2012. - Vol. 4. - P. 352-357.

Hellemans P., van Dam P.A., Geyskens M. et al. Immunohistochemical study of topoisomerase ІІ-alpha expression in primary ductal carcinoma of the breast // J Clin Pathol. - 1995. - Vol. 48. - P. 147-150.

Jakobsen J.N., Sorensen J.B. Clinical impact of Ki-67 labeling index in non-small cell lung cancer // Lung Cancer. - 2013. - Vol. 79. - P. 1-7.

Martin B., Paesmans M., Mascaux C. et al. Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis // Br J Cancer. - 2004. - Vol. 91. - P. 2018-2025.

Ogura S., Abe S., Sukoh N. et al. Correlation between nucleolar organizer regions visualized by silver staining and the growth rate of lung adenocarcinoma // Cancer (Philad). - 1992. - Vol. 70. - P. 63-68.

Rodrigues O.R., Antonangelo L., Yagi N. et al. Prognostic significance of argyrophilic nucleolar organizer region (AgNOR) in resected non-small cell lung cancer (NSCLC) // Jpn J Clin Oncol. - 1997. - Vol. 27. - P. 298-304.

Sirri V., Roussel P., Hernandez-Verdun D. The AgNOR proteins: qualitative and quantitative changes during the cell cycle // Micron. - 2000. - Vol. 31. - P. 121-126.

Sobin L., Gospodarowicz M., Wittekind C. (Eds.): TNM classification of malignant tumours. 7th ed. Oxford, Wiley-Blackwell. - 2009. - P. 138-146.

Trere D. AgNOR staining and quantification // Micron. - 2000. - Vol. 31. - P. 127-131.

Yan S., Shun-Chang J., Li C. et al. Topoisomerase ІІ alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer // BMC Cancer. - 2010. - Vol. 10. - P. 621.

All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...