The reaction of the immune system to insulin-like growth factor-1 in postmenopausal women with breast cancer
Vol. 69 No. 6 (2023), Articles
Vol. 69 No. 6 (2023)

The reaction of the immune system to insulin-like growth factor-1 in postmenopausal women with breast cancer

Articles
https://doi.org/10.37469/0507-3758-2014-60-2-69-71
Published 15.12.2014
I.P. Pavlov State Medical University
I.P. Pavlov State Medical University
I.P. Pavlov State Medical University
I.P. Pavlov State Medical University
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PDF (Русский)

Keywords

breast cancer
IGF-1
prostaglandin synthesizing cells
cells to histamine receptors

How to Cite

, , , & . (2014). The reaction of the immune system to insulin-like growth factor-1 in postmenopausal women with breast cancer. Voprosy Onkologii, 69(6), 69–71. https://doi.org/10.37469/0507-3758-2014-60-2-69-71
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Abstract

Taking into account the information about the role of insulin-like growth factor -1 (IGF-1) in breast cancer the main aim of the present study was to investigate the cellular immune response to IGF- 1. There were examined 58 patients with breast cancer (61 ±1 years , ВМІ 31,2 ± 0,9 kg/m2 , all postmenopausal ) and 10 with benign tumors of the breast (56 ± 2 years , ВМІ 30,8 ± 0,7 kg/m2 all menopausal ) as well as 17 patients suffering from cancer of different sites. Sensibilization of lymphocytes to IGF-1 was measured in the reaction of blast transformation of peripheral blood lymphocytes. The majority of breast cancer patients (47/58) revealed the sensibilization of peripheral blood lymphocytes to IGF-1. Thus in a part of patients (29 /47) this reaction was suppressed and revealed after suppression of cyclooxygenase and/or blocking of the histamine H2-receptors by corresponding pharmaceutics drugs in vitro.
https://doi.org/10.37469/0507-3758-2014-60-2-69-71
##article.numberofdownloads## 62
##article.numberofviews## 84
PDF (Русский)

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