Keywords
How to Cite
Abstract
Cervical cancer takes the second place in the structure of morbidity and the third place in the structure of mortality from oncogynecological pathology. A portion of advanced stages among newly diagnosed cases is still great. “Gold standard” of treatment for locally advanced cervical cancer is chemoradio-therapy with cisplatin that leads to a lower risk of death from this disease. Improvement of radiotherapy methods allowed to bring optimal dose to the primary tumor with the inclusion of regional metastasis areas with less risk of damage to surrounding healthy tissue and organs. The search for alternative combinations of cytostatics, modes of drug administration, adjuvant chemotherapy after chemoradiotherapy showed an increase of survival in locally advanced cervical cancer patients.References
Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2012 году (заболеваемость и смертность). // М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России. - 2014. - С. 258.
Кравец О.А. Лучевая терапия местно-распространенного рака шейки матки (оптимизация лечения, факторы прогноза): диссертация на соискание ученой степени доктора мед. наук. - М.: ФГБУ «РОНЦ имени Н.Н. Блохина» РАМН. - 2010. - С. 6-7.
Кузнецов В.В. Федеральные клинические рекомендации по диагностике и лечению рака шейки матки. - Москва. - 2014. - С. 9-10.
Максимов С.Я., Гусейнов К.Д., Баранов С.Б. Химиолучевая терапия рака шейки и рака тела матки. // Практическая онкология. - 2008. - т. 9. - н. 1. - С. 39-46.
Моисеенко В.М. Практические рекомендации по лечению злокачественных опухолей Общества онкологов-химиотерапевтов RUSSCO. - М.: Общество онкологов-химиотерапевтов. - 2013. - С. 142-146.
Салчак Ч.Т. Химиолучевая терапия рака шейки матки с использованием препаратов платины: диссертация на соискание ученой степени канд. мед. наук. - Москва. - 2009.
Тюляндин С.А., Моисеенко В.М. Практическая онкология: избранные лекции. - Москва. - 2004. - С. 689.
Cetina L., Rivera L., Candelaria M., et al. Chemoradiation with gemcitabine for cervical cancer in patients with renal failure. // Anticancer Drugs. - 2004. - v. 15. - p. 761-6.
Chumworathayi B., Yuenyao P., Tangvorapongchai V., et al. Weekly gemcitabine and cisplatin concurrent with pelvic irradiation for primary therapy of cervical cancer: report of the first seven cases in Thai women. // Radiat Med. - 2007. - v. 25. - p. 474-9.
Duenas-Gonzalez A., Zarba J.J., Patel F., et al. Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus Concurrent Cisplatin and Radiation in Patients With Stage IIB to IVA Carcinoma of the Cervix. // J Clin Oncol. - 2011. - v. 29. - N. 13. - p. 1678-1685.
Duenas-Gonzalez A., Orlando M., Zhou Y. et al. Efficacy in high burden locally advanced cervical cancer with concurrent gemcitabine and cisplatin chemoradiotherapy plus adjuvant gemcitabine and cisplatin: prognostic and predictive factors and the impact of disease stage on out comes from a prospective ramdomized phase III trial. // Gynocol Oncol. - 2012. - v. 126. - N. 3. - p. 334-40.
Eifel P.J., Winter K., Morris M. et al. Pelvic Irradiation With Concurrent Chemotherapy Versus Pelvic and Para-Aortic Irradiation for High-Risk Cervical Cancer: An Update of Radiation Therapy Oncology Group Trial (RTOG) 90-01. // J Clin Oncol. - 2004. - v. 22. - N. 5. - p. 872-880.
Fabbro M.1, Gladieff L., Guichard F., et al. Phase I study of irinotecan and cisplatin in combination with pelvic radiotherapy in the treatment of locally advanced cervical cancer: A GINECO trial. // Gynecol Oncol. - 2010. - v. 117. - N. 2. - p. 276-80.
Geara F.B., Shamseddine A., Khalil A., et al. A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer. // Radiat Oncol. - 2010. - v. 5. - p. 84.
Hashemi F.A., Akbari E.H., Kalaghchi B., et al. Concurrent chemoradiation with weekly gemcitabine and cisplatin for locally advanced cervical cancer. // Asian Pac J Cancer Prev. - 2013. - v.14. - N. 9. - p. 5385-9.
Hreshchyshyn M.M., Aron B.S., Boronow R.C. et al. Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. // Int J Radiat Oncol Biol Phys. - 1979. - v. 5. - N. 3. - p. 317-22.
Lee M.X., Wu H.G., Kim K., et al. Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix. // Gynecol Oncol. - 2007. - v. 104. - N. 1. - p. 95-9.
Miglietta L., Franzone P., Centurioni M.G., et al. A phase II trial with cisplatin-paclitaxel cytotoxic treatment and concurrent external and endocavitary radiation therapy in locally advanced or recurrent cervical cancer. // Oncology. - 2006. - v. 70. - N. 1. - p. 19-24.
Morris M., Eifel P.J., LU J. et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. // N Engl J Med. - 1999. - v. 340. - N. 15. - p. 1137-43.
Pattaranutaporn P., Thirapakawong C., Chansilpa X. et al. Phase II study of concurrent gemcitabine and radiotherapy in locally advanced stage IIIB cervical carcinoma. // Gynecol Oncol. - 2001. - v. 81. - p. 404-7.
Perez C. Radiation therapy in the management of cancer of the cervix: Part II. // Oncology. - 1993. - v. 7. - p. 61-76.
Piver M.S., Barlow J.J., Vongtama V. et al. Hydroxyurea: a radiation potentiator in carcinoma of the uterine cervix. A randomized double-blind study. // Am J Obstet Gynecol. - 1983. - v. 147. - N. 7. - p. 803-8.
Porras A.R., Valencia N., Bastarrachea J., et al. Weekly gemcitabine concurrently to external radiotherapy for cervical cancer stage IB2- IVA. // ASCO Annual Meeting. - 2003. - Abstract 1987.
Rao G.G., Rogers P., Drake R.D., et al. Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer. // Gynecol Oncol. - 2005. - v. 96. - N. 1. - p. 168-72.
Rodriguez-Peral J.J. et al. Locally advanced cervical carcinoma (LACC) treated with concurrent gemcitabine (GEM) and radiotherapy (RT). // ASCO Annual Meeting. - 2003. - Abstract 1988.
Rose P.G., Bundy B.N., Watkins E.B. et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. // N Engl J Med. - 1999. - v. 340. - N. 15. - p.1144-53.
Rose P.G., Shamshad Ali, Watkins E.B. et al. Long-Term Follow-Up of a Randomized Trial Comparing Concurrent Single Agent Cisplatin, Cisplatin-Based Combination Chemotherapy, or Hydroxyurea During Pelvic Irradiation for Locally Advanced Cervical Cancer: A Gynecologic Oncology Group Study. // J Clin Oncol. - 2007. - v. 25. - N.19. - p. 2804-2810.
Rose P.G., Degeest K., McMeekin S., et al. A phase I study of gemcitabine followed by cisplatin concurrent with whole pelvic radiation therapy in locally advanced cervical cancer: a Gynecologic Oncology Group study. // Gynecol Oncol. - 2007. - v. 107. - p. 274-9.
Shewach D.S.1, Lawrence T.S. et al. Gemcitabine and radiosensitization in human tumor cells. // Invest New Drugs. 1996. - v. 14. - N. 3. - p. 257-63.
Sol E.S., Lee T.S., Koh S.B., et al. Comparison of concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil versus cisplatin plus paclitaxel in patients with locally advanced cervical carcinoma. // J Gynecol Oncol. - 2009. - v. 20. - N. 1. - p. 28-34.
Stehman F.B., Bundy B.N., Thomas G. et al. Hydroxyurea Versus Misonidazole With Radiation in Cervical Carcinoma: Long-Term Follow-Up of a Gynecologic Oncology Group Trial. // Journal of Clinical Oncology. - 1993. - v. 11. - N. 8. - p. 1523-1528.
Swisher E.M., Swensen R.E., Greer B., et al. Weekly gemcitabine and cisplatin in combination with pelvic radiation in the primary therapy of cervical cancer: a phase I trial of the Puget Sound Oncology Consortium. // Gyne Oncol Oncol. - 2006. - v. 101. - p. 429-35.
Umanzor J., Aguiluz M., Pineda C., et al. Concurrent Chemoradiation in locally advanced cervical carcinoma (LACC): role of a combination of cisplatin, gemcitabine and radiotherapy- a phase II trial. // ASCO Annual Meeting. - 2003. - Abstract 1953.
Verma A.K., Arya A.K., Kumar M., et al. Weekly cisplatin or gemcitabine concomitant with radiation in the management of locally advanced carcinoma cervix: results from an observational study. // J Gynecol Oncol. - 2009. - v. 20. - N. 4. - p. 221-226.
Wang S., Zhang D.S., Pan T., et al. Efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on advanced cervical cancer. // Chinese Juornal of Cancer. - 2010. - v. 29. - N. 11. - p. 959-63.
Whitney C.W., Sause W., Bundy B.N. et al. Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study.// Journal of Clinical Oncology. - 1999. - v.17. - N. 5. - p. 1339-1348.
Zarba J.J., Jaremtchuk A.V., Gonzalez Jazey P., et al. A phase I-II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervix carcinoma. // Ann Oncol. - 2003. - v. 14. - p. 1285-90.
Zhang M.Q., Liu S.P., Wang X.E. Concurrent Chemoradiotherapy with Paclitaxel and Nedaplatin followed by Consolidation Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix: Preliminary Results of a Phase II Study. // Int. J. Radiation Oncology Biol. Phys. - 2010. - v. 78. - N. 3. - p. 821-827.
All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical 'Problems in oncology' ...