How to Cite
Abstract
.
The review provides information on the main saliva biomarkers in squamous cell carcinoma of the oral mucosa. Squamous cell carcinoma of the oral mucosa is the most common among the oncologic diseases of the maxillofacial region. Patients still appeal for help at the last stages of neoplastic process despite accessible visualization. The dentist is the first physician who can suspect a neoplastic process. However, in order to receive advice from oncologists and to have a final clinical diagnosis made, the patient needs to visit a number of extra hospital departments. Free unstimulated oral fluid is an excellent diagnostic material, in particular, for the early diagnosis of diseases of the oral cavity. Saliva has a direct contact with the pathology of the oral mucosa; its sampling does not require sterile instrumentation and special skills, which increases its informational value.
The literature published over the last 5 years originated from the databases PubMed MedLine, The Cochrane Library, EMBASE, Global Health and CyberLeninka platforms, and eLibrary.Ru has been analyzed. The biomarkers that have been studied for the moment has insufficient specificity for diagnostics or differentiation of the oral cavity diseases. This makes it relevant to study to investigate the expression of saliva biomarkers in patients with burdened tumor history as well as correlations with clinical state of the patient’s oral cavity.
References
Proctor GB, Shaalan AM. Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva // J Dent Res. 2021;100(11):1201–1209. doi:10.1177/00220345211004842
Мартусевич А.К., Ковалева Л.К., Козлова Л.М. и др. Изучение дегидратационной структуризации ротовой жидкости человека на твердой подложке // Клиническая стоматология. 2020;3(95):4–9. doi:10.37988/1811-153X_2020_3_4 [Martusevich AK, Kovaleva LK, Kozlova LM et al. Study of dehydration structuring of human oral fluid on a solid support // Clinical dentistry. 2020;3(95):4–9 (In Russ.)]. doi:10.37988/1811-153X_2020_3_4
Щубелко Р.В., Зуйкова И.Н., Шульженко А.Е. и др. Рецидивирующие воспалительные заболевания ротоглотки Роль факторов мукозального иммунитета // Иммунология. 2019;1(40):35–43. doi:10.24411/0206-4952-2019-11004 [Shchubelko RV, Zuikova IN, Shulzhenko AE et al. Recurrent inflammatory diseases of the oropharynx The role of mucosal immunity factors // Immunology. 2019;1(40):35–43 (In Russ.)]. doi:10.24411/0206-4952-2019-11004
Rivera C, Oliveira AK, Costa RAP et al. Prognostic biomarkers in oral squamous cell carcinoma: A systematic review // Oral Oncol. 2017;72:38–47. doi:10.1016/j.oraloncology.2017.07.003
Максимов А.Ю., Костоев И.С., Демидова А.А. и др. Дифференциальная биоинформационная модель диагностики воспалительных и опухолевых заболеваний околоушной слюнной железы // Стоматология. 2021;1(100):24–29. doi:10.17116/stomat202110001124 [Maksimov AYu, Kostoev IS, Demidova AA et al. Differential bioinformation model for the diagnosis of inflammatory and tumor diseases of the parotid salivary gland // Dentistry. 2021;1(100):24–29 (In Russ.)]. doi:10.17116/stomat202110001124
Yang Z, Liang X, Fu DOI et al. Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma // EBioMedicine. 2019;47:44–57. doi:10.1111/jop.12660
Alsarraf A, Kujan O, Farah CS. The utility of oral brush cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review // J Oral Pathol Med. 201847(2):104–116. doi:10.1111/jop.12660
Celentano A, McCullough M, Cirillo N. Glucocorticoids reduce chemotherapeutic effectiveness on OSCC cells via glucose-dependent mechanisms // J Cell Physiol. 2019;234(3):2013–2020. doi:10.1371/journal.pone.0191683
Chea C, Miyauchi M, Inubushi T et al. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma // PLoS One. 2018;13(1):e0191683. doi:10.1371/journal.pone.0191683
Chattopadhyay I, Verma M, Panda M. Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer // Technol Cancer Res Treat. 2019;18. doi:10.1177/1533033819867354
Nikolenko VN, Kozlov SV, Kochurova EV. The effect of risk factors for a malignant neoplasm in the maxillofacial region on the expression of matrix metalloproteinases and their tissue inhibitors in elderly and old patients // Advances in Gerontology. 2015;1(5):50–53. doi:10.1134/S2079057015010087
Wen B, Tsai CS et al. Cancer risk among gingivitis and periodontitis patients: A nationwide cohort study // QJM. 2014;107:283–290. doi:10.1093/qjmed/hct248
Afacan B, Çınarcık S, Gürkan A et al. Full-mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N-telopeptide of Type I collagen in severe periodontitis // J Periodontol. 2020;91(5):638–650. doi:10.1002/JPER.19-0445
Romano F, Bongiovanni L, Bianco L et al. Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment // Clin Oral Investig. 2018;22(2):1083–1092. doi:10.1007/s00784-017-2192-1
Khalid DOI, Varghese SS, Sankari M, Jayakumar N.D. Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment // J Clin Diagn Res. 2017;11(4):ZC78–ZC81. doi:10.7860/JCDR/2017/24518.9698
Базарный В.В., Полушина Л.Г., Семенцова Е.А. и др. Являются ли саливарные цитокины семейства ИЛ-1 биомаркерами хронического пародонтита? // Проблемы стоматологии. 2020;3(16):18–22. doi:10.18481/2077-7566-2020-16-3-18-22 [Bazarny VV, Polushina LG, Sementsova EA et al. Are salivary cytokines of the IL-1 family biomarkers of chronic periodontitis? // Dentistry problems. 2020;3(16):18–22 (In Russ.)]. doi:10.18481/2077-7566-2020-16-3-18-22
Базарный В.В., Мандра Ю.В., Полушина Л.Г. и др. Клиническая информативность хемокинов ротовой жидкости при хроническом пародонтите // Медицинская иммунология. 2021;2(23):345–352. doi:10.15789/1563-0625-CVO-2162 [Bazarny VV, Mandra YuV, Polushina LG et al. Clinical information content of oral fluid chemokines in chronic periodontitis // Medical immunology. 2021;2(23):345–352 (In Russ.)]. doi:10.15789/1563-0625-CVO-2162
Успенская О.А., Кондюрова Е.В., Спиридонова С.А. Динамика маркеров перекисного окисления липидов ротовой жидкости при хроническом пародонтите // Институт стоматологии. 2021;2(91):74–75 [Uspenskaya OA, Kondyurova EV, Spiridonova SA. Dynamics of markers of lipid peroxidation of the oral fluid in chronic periodontitis // Institute of Dentistry. 2021;2(91):74–75 (In Russ.)].
Popov K, Bykova N, Shvets O et al. Peculiarities of evaluation of the oral fluid antioxidant activity in patients with local or systemic diseases // Georgian Med News. 2021;(311):68–73.
Luan X, Zhou X, Naqvi A et al. MicroRNAs and immunity in periodontal health and disease // Int J Oral Sci. 2018;10(3):24. doi:10.1038/s41368-018-0025
Camisasca DR, da Rós Gonçalves L, Soares MR et al. A proteomic approach to compare saliva from individuals with and without oral leukoplakia // J Proteomics. 2017;151:43–52. doi:10.1016/j.jprot.2016.07.029
Kochurova EV, Nikolenko VN. Estimation of expression of oral fluid biomarkers in the diagnosis of pretumor diseases of oral mucosa // Bulletin of Experimental Biology and Medicine. 2017;163(1):87–91. doi:10.1007/s10517-017-3744-8
Boia S, Stratul ŞI, Boariu M et al. Evaluation of antioxidant capacity and clinical assessment of patients with chronic periodontitis treated with non-surgical periodontal therapy and adjunctive systemic antibiotherapy // Rom J Morphol Embryol. 2018;59(4):1107–1113.
Kochurova EV, Nikolenko VN. Matrixins in the Salivary Fluid of Patients with Tumors of the Maxillofacial Region during Orthopedic Rehabilitation with Different Prosthetic Structures // Bulletin of Experimental Biology and Medicine. 2017;163(5):663–666. doi:10.1007/s10517-017-3874-z
Rajagopal S, Chander NG, Anitha KV, Balasubramaniam M. Evaluation of Psychological Stress Marker in Partially Edentulous Indian Adults Restored with Fixed Dental Prosthesis ― A Prospective Cohort Study // Contemp Clin Dent. 2020;11(2):116–120. doi:10.4103/ccd.ccd_63_20
Petrakova L, Doering BK, Vits S et al. Psychosocial stress increases salivary alpha-amylase activity independently from plasma noradrenaline levels // PLoS One 2015;10:e0134561. doi:10.1371/journal.pone.0134561
Бельская Л.В., Косенок В.К. Уровень цитокинов в слюне при раке молочной железы // Вопросы онкологии. 2019;6(65):825–831. doi:10.37469/0507-3758-2019-65-6-825-831 [Belskaya LV, Kosenok VK. The level of cytokines in saliva in breast cancer // Oncology issues. 2019;6(65):825–831 (In Russ.)]. doi:10.37469/0507-3758-2019-65-6-825-831
Shi J, Bao X, Liu Z et al. Serum miR-626 and miR-5100 are promising prognosis predictors for oral squamous cell carcinoma // Theranostics. 2019;9(4):920–931. doi:10.7150/thno.30339
Кочурова Е.В., Николенко В.Н., Муханов А.А., Деменчук П.А. Стоматологический статус как прогностический фактор развития плоскоклеточного рака слизистой оболочки полости рта // Стоматология. 2019;4(98):34–37. doi:10.17116/stomat20199804134 [Kochurova EV, Nikolenko VN, Mukhanov AA, Demenchuk PA. Dental status as a prognostic factor for the development of squamous cell carcinoma of the oral mucosa // Dentistry. 2019;4(98):34–37 (In Russ.)]. doi:10.17116/stomat20199804134
Джураева Ш.Ф., Чистенко Г.Н., Терехова Т.Н., Иконникова А.В. Рак полости рта: факторы риска и скрининг // Современная стоматология. 2020;2(79):3–7 [Dzhuraeva ShF, Chistenko GN, Terekhova TN, Ikonnikova AV. Oral cancer: risk factors and screening // Modern dentistry. 2020;2(79):3–7 (In Russ.)].
Кутукова С.И., Беляк Н.П., Раскин Г.А. и др. Анализ выживаемости больных плоскоклеточным раком слизистой оболочки полости рта в зависимости от экспрессии PD-L1 // Пародонтология. 2020;4(25):287–294. doi:10.33925/1683-3759-2020-25-4-287-294 [Kutukova SI, Belyak NP, Raskin GA et al. Analysis of the survival rate of patients with squamous cell carcinoma of the oral mucosa depending on the expression of PD-L1 // Periodontics. 2020;4(25):287–294 (In Russ.)]. doi:10.33925/1683-3759-2020-25-4-287-294
Khurshid Z, Zafar MS, Khan RS et al. Rehman IU. Role of salivary biomarkers in oral cancer detection // Adv Clin Chem. 2018;86:23–70. doi:10.1016/bs.acc.2018.05.002
Aali M, Mesgarzadeh AH, Najjary S et al. Evaluating the role of microRNAs alterations in oral squamous cell carcinoma // Gene. 2020;757:144936. doi:10.1016/j.gene.2020.144936
Shinn JR, Davis SJ, Lang-Kuhs KA et al. Oropharyngeal squamous cell carcinoma with discordant p16 and hpv mrna results: incidence and characterization in a large, contemporary united states cohort // Am J Surg Pathol. 2021;45(7):951–961. doi:10.1097/PAS.0000000000001685
Kim J., Park, Roh JL et al. Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer // Int. J. Clin. Oncol. 2016;21:883–889. doi:10.1007/s10147-016-0973-1
Sasahira T, Bosserhoff AK, Kirita T. The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer // Pathol. Int. 2018;68:278–286. doi:10.1111/pin.12672
Gonzalez-Garcia R, Naval-Gias L, Rodriguez-Campo FJ et al. Contralateral lymph neck node metastasis of squamous cell carcinoma of the oral cavity: a retrospective analytic study in 315 patients // J. Oral Maxillofac. Surg. 2008;66:1390–1398. doi:10.1016/j.joms.2008.01.012
Sasahira T, Kirita T. Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma // Int J Mol Sci. 2018;19(8):2413. doi:10.3390/ijms19082413
Yellapurkar S, Natarajan S, Boaz K et al. Expression of Laminin in Oral Squamous Cell Carcinomas // Asian Pac J Cancer Prev. 2018;19(2):407–413. doi:10.22034/APJCP.2018.19.2.407
Dumache R. Early Diagnosis of Oral Squamous Cell Carcinoma by Salivary microRNAs // Clin Lab. 2017;63(11):1771–1776. doi:10.7754/Clin.Lab.2017.170607
Granato DC, Neves LX, Trino LD et al. Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients // Biochim Biophys Acta Proteins Proteom. 2021;1869(8):140659. doi:10.1016/j.bbapap.2021.140659
Hayes RB, Ahn J, Fan X et al. Association of oral microbiome with risk for incident head and neck squamous cell cancer // JAMA Oncol. 2018;4(3):358–365. doi:10.1001/jamaoncol.2017.4777
Gholizadeh P, Eslami DOI, Yousefi M et al. Role of oral microbiome on oral cancers, a review // Biomed Pharmacother. 2016;84:552–558. doi:10.1016/j.biopha.2016.09.082
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2022