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Abstract
In recent years in oncology epithelial cells of properties and signs of mesenchymal cells note significant growth in interest in the epithelial - mesenchymally transition (EMT) – to acquisition process.
Now the convincing evidence that EMP plays an important role in an embryogenesis, when healing wounds and forming fibrosis is obtained and it is involved in a pathogeny of development and progressing of malignant new growths. In article EMP role in innidiation on the example of a breast cancer is discussed. Modern data on the EMP molecular and biological mechanisms with discussion of the importance of the major inductors and regulators of this process are provided. The role of genetic factors and a tumoral microenvironment in the course of EMP is shown. The problem of interrelation of EMP and forming of cancer stem cells is separately discussed.
References
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