THE ROLE OF SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY AND X-RAY COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF LYMPH NODE METASTASES IN PATIENTS WITH SMALL CELL LUNG CANCER
Vol. 60 No. 4 (2014), Articles
Vol. 60 No. 4 (2014)

THE ROLE OF SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY AND X-RAY COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF LYMPH NODE METASTASES IN PATIENTS WITH SMALL CELL LUNG CANCER

Articles
https://doi.org/10.37469/0507-3758-2014-60-4-477-482
Published 15.12.2014
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
N.N. Petrov Research Institute of Oncology
PDF (Русский)

Keywords

emission tomography (SPECT)
lung cancer

How to Cite

, , , , , , , , , , & . (2014). THE ROLE OF SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY AND X-RAY COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF LYMPH NODE METASTASES IN PATIENTS WITH SMALL CELL LUNG CANCER. Voprosy Onkologii, 60(4), 477–482. https://doi.org/10.37469/0507-3758-2014-60-4-477-482
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Abstract

Single photon emission tomography (SPECT) with 99mTc-MIBI was performed after conventional staging in 83 operated non-small cell lung cancer (NSCLC) patients. Diagnostic results of SPECT and conventional computerized tomography (CT) staging were validated by histological examinations of operation material. According to histological verification 35 of 83 evaluated patients had lymph node (LN) invasion by NSCLC. SPECT detected LN involvement in 28 of these 35 patients and was false positive in additional 16 patients. Pneumonia or atelectasis were detected in 12 of 16 patients with false positive SPECT results. Sensitivity (Sen), specificity (Sp), accuracy (Ac), positive (PPV) and negative (NPV) predictive values of SPECT in diagnosis of LN invasion by NSCLC was as follows: 80 %, 66 %, 72 %, 65 %, 82 %. Diagnostic accuracy of CT for detection of LN involvement was inferior to SPECT: Sen - 71 %, Sp - 62 %, Ac - 66 %, PPV - 58 %, NPV - 75 %. Combination of SPECT and CT data offer promising solutions with Sen reached 94 % or high Sp which in patients without atelectasis or pneumonia can reach 96 %.
https://doi.org/10.37469/0507-3758-2014-60-4-477-482
PDF (Русский)

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