Vol. 70 No. 2 (2024), ORIGINAL ARTICLES. C. CLINICAL RESEARCH

Vol. 70 No. 2 (2024)

Experience of Using Stereotactic Ablative Radiotherapy for Radical Treatment of Low and Intermediate Risk Prostate Cancer

ORIGINAL ARTICLES. C. CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2024-70-2-292-298

Published 06.05.2024

Sergey N. Novikov

N.N. Petrov National Medicine Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-7185-1967

Nikolay D. Ilyin

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0001-6472-0427

Yulia S. Melnik

. N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-3541-2764

Olga I. Ponomareva

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-8314-3722

Roman V. Novikov

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0003-1873-1293

Yuriy O. Merezhko

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0003-1491-2644

Ekaterina E. Samartseva

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0009-0008-8585-0982

Maria Yu. Gotovchikova

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-7185-1967

Andrey I. Arsenev

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-3100-6451

Filipp E. Antipov

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-8505-4977

Vasiliy K. Karandashov

"Military Medical Academy named after S. M. Kirov" of the Ministry of Defense of the Russian Federation, St. Petersburg

https://orcid.org/0009-0001-5155-9491

Sergey M. Gozalishvili

"Military Medical Academy named after S. M. Kirov" of the Ministry of Defense of the Russian Federation, St. Petersburg

https://orcid.org/0009-0008-3354-7981

Nikita O. Kuznetsov

I.P. Pavlov St. Petersburg State Medical University, the Russian Federation

https://orcid.org/0009-0008-6497-6404

Sergey V. Kanaev

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0002-1753-7926

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Keywords

prostate cancer
stereotactic radiotherapy

How to Cite

Novikov, S. N., Ilyin, N. D., Melnik, Y. S., Ponomareva, O. I., Novikov, R. V., Merezhko, Y. O., Samartseva, E. E., Gotovchikova, M. Y., Arsenev, A. I., Antipov, F. E., Karandashov, V. K., Gozalishvili, S. M., Kuznetsov, N. O., & Kanaev, S. V. (2024). Experience of Using Stereotactic Ablative Radiotherapy for Radical Treatment of Low and Intermediate Risk Prostate Cancer. Voprosy Onkologii, 70(2), 292–298. https://doi.org/10.37469/0507-3758-2024-70-2-292-298

Abstract

Aim. To evaluate efficacy and safety of stereotactic ablative radiotherapy (SABR) as a radical treatment of low and intermediate risk prostate cancer (LIRPC).

Material and Methods. From April 2014 to June 2018, 111 primary patients with clinically localized LIRPC were treated with SABR as a monotherapy. SABR was delivered in 5 fractions of 7.25 Gy according to the standard technology: after 2-3 marker placement, MRI, X-ray computed tomography (CT) scanners, and using the Eclipse treatment planning system with the volumetric-modulated arc therapy (VMAT) planning. Five-year biochemical recurrence-free survival (BRFS) was assessed according to the «Phoenix definition» biochemical recurrence criteria. Toxicity was scored according to the RTOG and CTAE.

Results. The median follow-up time was 78 (60-110) months. BRFS for both the groups was 91 %: 95.5 % - for low risk and 88.2 % - for intermediate risk patients. Local control was 97.3 %. Grade II genitourinary toxicity was detected in 11 cases (10 %) and grade III in 1 case (0.9 %). Grade II rectal toxicity was observed in 6 patients (5.4 %), while no grade III toxicity was observed.

Conclusion. The results of the 5-year follow-up after SABR in LIRPC patients demonstrated the high efficacy and safety of the procedure, allowing it to be recommended for wide clinical use.

https://doi.org/10.37469/0507-3758-2024-70-2-292-298

##article.numberofdownloads## 61

##article.numberofviews## 129

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