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Abstract
Aim. To compare the outcomes of stage I-IIIB/C non-small cell lung cancer (NSCLC) after bronchoplastic (BP) sleeve resection (BP) and pneumonectomy (PN).
Material and Methods. From August 2006 to August 2022 data on 431 patients with primary NSCLC stage I-IIIB/C who underwent PN or BP as a surgical treatment were collected. A total of 173 patients were selected for analysis in each group. The endpoints were 30-day and 90-day postoperative mortality, desease-free survival (DFS), and observed (overall) survival (OS).
Results. There were no statistically significant differences between the groups for 30-day and 90-day mortality (p = 0.62 and p = 0.388, respectively). BP showed similar rates of local and locoregional recurrence to PN (p = 1,000). DFS in the BPc group was 76 % versus 72 % in the PN group for one year, 59 % versus 52 % for three years, and 57 % versus 46 % (p = 0.066) for five years. OS was 63.0 ± 16.84 (95 % CI: 30.0-96.0) months in BP vs 31 ± 5.4 (95 % CI: 20.41-41.59) months in PN (p = 0.014; HR = 0.703 [0.529-0.935]), 5-year OS was 52 % vs 38 %, 10-year survival was 29 % vs 25 %, respectively.
Conclusion. When comparing immediate endpoints such as 30 and 90 day post-operative mortality, comparable results were obtained. DFS, particularly local control, is comparable between two groups. BPs improve long-term OS compared to PN for all stages except IIIB/C.
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