Федеральной государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии имении Н.Н.Петрова» Министерства Здравоохранения Российской Федерации

https://orcid.org/0000-0002-9051-2637

Nikolay V. Khandogin

N.N. Petrov National Medicine Research Center of Oncology, St. Petersburg, the Russian Federation

https://orcid.org/0000-0001-6046-549X

Roman Ivanovich Yurin

NMRC of Oncology named after N.N.Petrov of MoH of Russia

https://orcid.org/0000-0003-4303-8132

Olga Olegovna Lopushanskaya

NMRC of Oncology named after N.N.Petrov of MoH of Russia

https://orcid.org/0000-0003-4465-3874

Victoriya Igorevna Shabinskaya

NMRC of Oncology named after N.N.Petrov of MoH of Russia

https://orcid.org/0000-0003-3226-429X

Azat Inzirovich Murtazin

NMRC of Oncology named after N.N.Petrov of MoH of Russia

https://orcid.org/0000-0001-5204-0942

Alina Albertovna Valitova

NMRC of Oncology named after N.N.Petrov of MoH of Russia

https://orcid.org/0000-0001-5204-0942

Evgeniy Vladimirovich Levchenko

NMIC of Oncology named after N.N. Petrov of the Ministry of Health of Russia

https://orcid.org/0000-0003-3837-2515

pdf (Русский)

Keywords

lung cancer
surgical treatment of lung cancer,
signal lymph nodes
ymphatic outflow
mTc-99
radionavigation surgery

How to Cite

Badaev , K. D., Novikov, S. N., Krzhivitsky , P. I., Levchenko, N. E., Yergnyan , S. M., Mamontov, O. Y., Khandogin , N. V., Yurin, R. I., Lopushanskaya, O. O., Shabinskaya, V. I., Murtazin, A. I., Valitova, A. A., & Levchenko, E. V. (2024). The original article Results of Using Intraoperative Sentinel Lymph Node Identification in the Surgical Management of Stage IA-IIA Non-Small Cell Lung Cancer. Voprosy Onkologii, 70(2), 308–315. https://doi.org/10.37469/0507-3758-2024-70-2-308-315

Abstract

Introduction. To evaluate the applicability, sensitivity and accuracy of the method of intraoperative determination of lymph flow pathways from the affected lobe and identification of sentinel lymph nodes in the surgical management of stage IA-IIA non-small cell lung cancer.

Materials and Methods. This prospective study has been conducted since November 2021 at the Department of Thoracic Oncology of the N.N. Petrov National Medical Research Centre of Oncology of the Ministry of Health of Russia. The study was approved by the local ethics committee № 1035 dated 08.10.2021. The analysis included 35 people.

Results. The SNLs were determined ex vivo in 34 of the 35 patients included in the study. In one case, it was not possible to reliably determine the radiopharmaceutical accumulation ex vivo and in the second and third points. According to the calculations, SLNs were identified in 97.14 % of cases. The number of patients with lymph node involvement was 5 out of 35. In five patients, metastatic lymph nodes were identified as sentinel lymph nodes. The accuracy of the method was 100 % (5 out of 5). The true negative rate was 30 out of 30 (100 %).

Conclusion. The results obtained using intraoperative peritumoral administration of radiopharmaceuticals to diagnose lymphatic flow and determine SLNs demonstrate the high accuracy of the method and warrant further study.

https://doi.org/10.37469/0507-3758-2024-70-2-308-315

pdf (Русский)

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