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Abstract
The aim of the study was to compare accuracy of conventional mammography and mammoscintigraphy with the 99mTc-Technetril in the detection of multicentric (MC) breast cancer. A total of 135 women (mean age 52 years) with unilateral simple breast lesions at clinical examination underwent preoperative mammography and mammoscintigraphy. Data of diagnostic procedure were compared with histopathologic analysis in all cases. The present of MC breast cancer was proven in 11 of 135 cases (8%). Mammography detected only one of 11 multicentric cases, while mammoscintigraphy — 9 of 11 cases. Mammography showed a 9,1% and 93,5% sensitivity and specificity rates for the detection of multicentric breast cancer, respectively. The overall sensitivity and specificity rates for the detection of the form were 81,8% and 91,1% for mammoscintigraphy, respectively. Сonfirmation of the distinction between two methods has been attained by Bayesian probability calculation. Mammoscintigraphy proved a more highly sensitive diagnostic method than mammography in the detection and preoperative assessment of MC breast cancer and may contribute to changing surgical management in some cases.References
Айвазян С.А., Мхитарян В.С. Прикладная статистика в задачах и упражнениях. — М.: 2001. — Юнити. — 270 с.
Berg W.A., Gilbreath P.L. Multicentric and multifocal cancer: whole-breast US in preoperative evaluation // Radiology. — 2000. — Vol. 214. — P. 59-66.
Berg W.A., Gutierrez L., NessAiver M.S. et al. Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer // radiology. — 2004. — Vol. 233. — P. 830-849.
Grosso M., Chiacchio S., Bianchi F. et al. Comparison between 99mTc-sestamibi scintimammography and X-ray mammography in the characterization of clusters of microcalcifications: a prospective long-term study // Anticancer Research. — 2009. — Vol. 29. — P. 4251-4258.
Holland R., Veling S.H.J., Mravunac M., Hendriks J.H.C.L. Histologic multifocality of Tis, T1-2 breast carcinoma: implications for clinical trials of breast-conserving surgery // Cancer. — 1985. — Vol. 56. — P. 979-990.
Massardo T., Alonso O., Llamas-Ollier A. et al. Planar Tc99m-sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocol: results of an international multicenter trial // BMC Nuclear Medicine. — 2005. — Vol. 5. — P. 1-7.
Mathieu I., Mazy S., Willemart B. et al. Inconclusive triple diagnosis in breast cancer imaging: is there a place foe scintimammography // J. Nucl. Med. — 2005. — Vol. 46. — P. 1574-1581.
Moon W.K., Noh D.Y., Im J.G. Multifocal, multicentric, and contralateral breast cancer: bilateral wholebreast US in the preoperative evaluation of patients // Radiology. — 2002. — Vol. 224. — P. 569-576.
Schillaci O., Danieli R., Filippi L. et al. Scintimammography with a hybrid SPECT/CT imaging system // Anticancer Research. — 2007. — Vol. 27. — P. 557-562.
Spanu A., Chessa F., Batista-Meloni G. et al. Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study // Q.J. Nucl. Med. Mol. Imaging. — 2009. — Vol. 53. — P. 133-143.
Spanu A., Chessa F., Sanna D. et al. Scintimammography with a high resolution dedicated breast camera in comparison with SPECT/CT in primary breast cancer detection // Q.J. Nucl. Med. Mol. Imaging. — 2009. — Vol. 53. — P. 271-280.
Usmani S., Khan H., Ahmed N. et al. Scintimammography in conjunction with ultrasonography for local breast cancer recurrence in post-mastectomy breast // Br. J. Radiol. — 2010. — Vol. 83. — P. 934-939.
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