Опыт применения дуоденальной активной аспирационной жидкостной биопсии в практике онкологических учреждений при диагностике новообразований поджелудочной железы

Kashintsev, A. A., Kokhanenko, N. Y., Pavelets, K. V., Soloviev, I. A., Rusanov, D. S., Vavilova, O. G., Radionov, Y. V., Dinikin, M. S., Agapov, M. Y., Pelipas, Y. V., Gulyaev, Y. A., Morgoshia, T. S., Magomedova, F. G., Solovyova, L. A., Nadeeva, A. A., Borovikova, A. S., Laptev, K. V., Lemeshev, A. V., & Proutski, V. Y. (2025). Clinical Application of Active Aspiration Fluid Biopsy for Pancreatic Neoplasia Diagnosis in Oncology Practice. Voprosy Onkologii, 71(6), OF–2340. https://doi.org/10.37469/0507-3758-2025-71-6-OF-2340

Abstract

Introduction. Differential diagnosis of pancreatic cystic neoplasms (PCNs) presents a significant clinical challenge due to their structural heterogeneity. Pancreatic juice represents a highly specific biological medium of particular interest, containing both cellular components and potential molecular biomarkers. We present a novel technique — Active Duodenal Aspiration Biopsy (DAB) — enabling collection of pancreatic juice-bile mixtures for diagnostic analysis.

Aim. To evaluate the efficacy of this original DAB technique when integrated with standard diagnostic modalities across different levels of oncology care institutions.

Materials and Methods. Patients with inconclusive standard diagnostic workups underwent DAB procedures. Aspirates were analyzed cytologically and through carcinoembryonic antigen (CEA) level quantification.

Results. In a case series of six patients with various pancreatic cystic neoplasms, DAB demonstrated feasibility and diagnostic utility when combined with conventional verification methods. CEA levels and cytological findings from DAB aspirates enabled precise diagnosis and informed treatment strategy modifications.

Conclusion. This preliminary experience indicates DAB is both safe and effective. The technique is applicable across outpatient and inpatient oncology settings and shows potential for improving early pancreatic cancer detection.

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2340

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