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Abstract
Recurrent respiratory papillomatosis (RRP) is a rare disease with an unpredictable course. The etiology is associated with the human papillomavirus (HPV). Malignant transformation of papillomas is extremely rare.
Two clinical cases of RRP malignization are presented. In the first case, 22-year-old women with a long history of RRP and the lower respiratory tract lesions, squamous cell lung cancer developed. Second case - development of squamous cell carcinoma from the tracheal papilloma in a 35-year-old patient. Aggressive local endobronchial treatment was carried out; however, the prognosis remains pessimistic due to the absence of etiopathogenetic therapy for RRP. Careful monitoring including HPV typing is mandatory, since infection with aggressive HPV strains leads to rapid proliferation of papillomas and malignant transformation.
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