ANTITUMOR EFFECT OF SUNITINIB AND BORTEZOMIB ON BREAST CANCER CELL LINE IN VITRO

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-1-141-145

Published 01.01.2017

Yuliya Khochenkova⁺⁻
Eliso Solomko⁺⁻
Oksana Ryabaya⁺⁻
Yevgeniya Stepanova⁺⁻
Dmitriy Khochenkov⁺⁻

Yuliya Khochenkova

N.N. Blokhin Russian Cancer Research Center Moscow

Eliso Solomko

N.N. Blokhin Russian Cancer Research Center Moscow

Oksana Ryabaya

N.N. Blokhin Russian Cancer Research Center Moscow

Yevgeniya Stepanova

N.N. Blokhin Russian Cancer Research Center Moscow

Dmitriy Khochenkov

N.N. Blokhin Russian Cancer Research Center Moscow

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Keywords

BREAST CANCER
SUNITINIB
BORTEZOMIB
КОМБИНИРОВАННАЯ ТЕРАПИЯ IN VITRO
COMBINED THERAPY IN VITRO

How to Cite

Khochenkova, Y., Solomko, E., Ryabaya, O., Stepanova, Y., & Khochenkov, D. (2017). ANTITUMOR EFFECT OF SUNITINIB AND BORTEZOMIB ON BREAST CANCER CELL LINE IN VITRO. Voprosy Onkologii, 63(1), 141–145. https://doi.org/10.37469/0507-3758-2017-63-1-141-145

Abstract

The discovery for effective combinations of anticancer drugs for treatment for breast cancer is the actual problem in the experimental chemotherapy. In this paper we conducted a study of antitumor effect of the combination of sunitinib and bortezomib against MDA-MB-231 and SKBR-3 breast cancer cell lines in vitro. We found that bortezomib in non-toxic concentrations can potentiate the antitumor activity of sunitinib. MDA-MB-231 cell line has showed great sensitivity to the combination of bortezomib and sunitinib in vitro. Bortezomib and sunitinib caused reduced expression of receptor tyrosine kinases VEGFR1, VEGFR2, PDGFRa, PDGFRß and c-Kit on HER2- and HER2+ breast cancer cell lines

https://doi.org/10.37469/0507-3758-2017-63-1-141-145

PDF (Русский)

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