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So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p<0.001), as well as the increased activity of alanine aminotransferase (p=0.044), alkaline phosphatase (p=0.008, p=0.049), and а-amylase (p=0.009). We have identified specifics of the change in the enzyme activity depending on a histological type of the tumour. There is the observable increased activity of а-amylase in the saliva in lung adenocarcinoma and neuroendocrine tumours (p<0.001). It was established that the enzyme activity decreases with a regional and distant metastasis independently of histological types of lung cancer.References
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