THE ROLE OF VASCULAR MICROENVIRONMENT IN THE FORMATION AND DEVELOPMENT OF BRAIN TUMORS
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Keywords

ANGIOGENESIS
PERIVASCULAR NICHE
TUMOR MICROENVIRONMENT
GLIAL STEM CELLS

How to Cite

Dorosevich, A., & Buzgan, N. (2018). THE ROLE OF VASCULAR MICROENVIRONMENT IN THE FORMATION AND DEVELOPMENT OF BRAIN TUMORS. Voprosy Onkologii, 64(5), 570–577. https://doi.org/10.37469/0507-3758-2018-64-5-570-577

Abstract

Processes of neovascularization are key for the growth and spread of tumor cells. This article describes unique patterns of angiogenesis, which are considered as specific exclusively for brain tumors. At present the role of specialized perivascular niches in the development of oncological processes of the brain acquires a growing importance in the eyes of researchers. Perivascular niches play a crucial role in intercellular interactions between resident cell lines in the development of the tumor process and are also a source of tumor stem cells.
https://doi.org/10.37469/0507-3758-2018-64-5-570-577
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PDF (Русский)

References

Брюховецкий И.С., Брюховецкий А.С., Кумейко В.В. и др. Стволовые клетки в канцерогенезе мультиформной глиобластомы // Гены и клетки. - 2013. - Т. 2. - С. 13-19.

Никифорова З.Н., Кудрявцев И.А., Арноцкая Н.Е. и др. Опухолевые стволовые клетки мультиформной глиобластомы // Успехи молекулярной онкологии. - 2016. - Т. 2. - С. 26-33.

Bergers G., Song S., Meyer-Morse N. et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors // J. Clin. Invest. - 2003. -Vol. 111. - P. 1287-1295.

Bugyik E., Renyi-Vamos F., Szabo V. et al. Mechanisms of vascularization in murine models of primary and metastatic tumor growth // Chin J. Cancer. - 2016. - Vol. 35. - P. 19-27.

Charles N., Ozawa T., Squatrito M. et al. Perivascular nitric oxide activates notch signaling and promotes stemlike character in PDGF-induced glioma cells // Cell Stem Cell. - 2010. - Vol. 6. - P. 141-152.

Codrici E., Enciu A.-M, Popescu I.-D. et al. Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets // Stem Cells Int. -2016. - Vol. 2016. - P. 1-20.

Coniglio S.J., Eugenin E., Dobrenis K. et al. Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling // Molecular Medicine. - 2012. - Vol. 18(1). - P. 519-527.

Doseff A., Parihar A. Monocyte subsets and their role in tumor progression // Biswas D. S. (Ed.). Tumor Microenvironment and Myelomonocytic Cells. Intech. - 2012. - P. 43-62. - DOI: 10.5772/32615

Ferretti E., Pistoia V., Corcione A. Role of Fractalkine/ CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies // Mediators Inflamm. - 2014. - Vol. 2014. - P 480941. -. DOI: 10.1155/2014/480941

Fidoamore A., Cristiano L., Antonosante A. et al. Glioblastoma stem cells microenvironment: the paracrine roles of the niche in drug and radioresistance // Stem Cells International. - 2016. - Vol. 2016. - 17 p.

Folkman J. Tumor angiogenesis: therapeutic implications // N. Engl. J. Med. - 1971. - Vol. 285. - P 1182-1186.

Gimsa U., Mitchison N.A., Brunner-Weinzierl M.C. Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation// Mediators Inflamm. - 2013. - Vol. 2013. - P. 320519. - DOI: 10.1155/2013/320519

Haley E.M., Kim Y The role of basic fibroblast growth factor in glioblastoma multiforme and glioblastoma stem cells and in their in vitro culture // Cancer Lett. - 2014. - Vol. 346 (1). - P. 1-5.

Hertz L., Gerkau N.J., Xu J. et al. Roles of astrocytic Na( ),K( )-ATPase and glycogenolysis for K( ) homeostasis in mammalian brain // J. Neurosci. Res. - 2015. -Vol. 93(7). - P 1019-1030.

Hjelmeland A.B., Wu Q., Heddleston J.M. et al. Acidic stress promotes a glioma stem cell phenotype // Cell Death Differ. - 2011. - Vol. 18(5). - P. 829-840.

Ho I.A.W., Shim W.S.N. Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity // Biomed Res Int. - 2017. - Vol. 2017. - P 9634172. -. DOI: 10.1155/2017/9634172

Huang P, Rani M. R. S., Ahluwalia M. S. et al. Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin a6ß1 in glioblastoma // Cancer Research. - 2012. - Vol. 72(6). - P. 1428-1437

Jkel S., Dimou L. Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation// Frontiers in Cellular Neuroscience. - 2017. - Vol. 11. - P. 24. - DOI: 10.3389/fncel.2017.00024

Kang S.H., Fukaya M., Yang J.K. et al. NG2 CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration // Neuron. -2010. - Vol. 68(4). - P. 668-681

Kenig S., Alonso M.B., Mueller M.M., Lah T.T. Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9 // Cancer Lett. - 2010. - Vol. 289. -P 53-61

Kessaris N., Fogarty M., Iannarelli P et al. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage // Nat. Neurosci. - 2006. - Vol. 9(2). - P. 173-179.

Kioi M., Vogel H.; Schultz G. et al. Inhibition of vasculo-genesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice // J. Clin. Invest. - 2010. - Vol. 120. - P 694-705.

Klemm F., Joyce J.A. Microenvironmental regulation of therapeutic response in cancer // Trends Cell Biol. - 2015. - Vol. 25(4). - P 198-213.

Kohanbash G., McKaveney K., Sakaki M. et al. GM-CSF promotes the immunosuppressive activity of glioma-Infiltrating myeloid cells through interleukin-4 receptor-a // Cancer Res. - 2013. - Vol. 73(21). - P 6413-6423.

Langer J., Rose C.R. Synaptically induced sodium signals in hippocampal astrocytes in situ// The Journal of Physiology. - 2009. - Vol. 587(24). - P 5859-5877.

Li G., Chen Z., Hu YD. et al.Autocrine factors sustain glioblastoma stem cell self-renewal // Oncol. Rep. - 2009. - Vol. 21. - P. 419-424.

Liebelt, B. D., Shingu, T., Zhou, X. et al. Glioma Stem Cells: Signaling, Microenvironment, and Therapy // Stem Cells Int. - 2016. - 2016. - P 7849890. - DOI: 10.1155/2016/7849890

Lin Q., Balasubramanian K., Fan D. et al. Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels // Neoplasia. - 2010. - Vol. 12(9). - P. 748-754.

Lindemann C., Marschall V., Weigert A. et al. Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner // Neoplasia. - 2015. - Vol. 17(6). - P 481-489.

Lobov I.B., Renard R.A., Papadopoulos N. et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting // Proc. Natl. Acad. Sci. U S A. - 2007. - Vol. 104(9). - P 3219-3224.

Lorger M. Tumor Microenvironment in the Brain // Cancers. - 2012. - Vol. 4(1). - P. 218-243.

Martinez F.O, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment // F1000Prime Reports. - 2014. - Vol. 6. - 13 p. - DOI: 10.12703/P6-13

Mobley J.L, Leininger M., Madore S. et al. Genetic evidence of a functional monocyte dichotomy // Inflammation. - 2007. - Vol. 30. - P. 189-197.

Nagaraj S., Youn J., Gabrilovich D.I. Reciprocal relationship between myeloid-derived suppressor cells and T cells // Journal of immunology. - 2013. - Vol. 191(1). - P 17-23.

Perng P., Lim M. Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites // Frontiers in Oncology. - 2015. - Vol. 5. - P. 153. - 10.3389/ fonc.2015.00153. DOI: 10.3389/fonc.2015.00153

Pietras A., Katz A.M., Ekstrm E.J. et al. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth // Cell Stem Cell. - 2014. - Vol. 14(3). - P. 357-369.

Potokar M., Jorgacevski J., Zorec R. Astrocyte aquaporin dynamics in health and disease // Int. J. Mol. Sci. - 2016. - Vol. 17(7). - P. 1121. -10.3390/ ijms17071121. DOI: 10.3390/ijms17071121

Qiang L., Wu T., Zhang H.W. et al. HIF-1alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway // Cell Death Differ. - 2012. - Vol. 19(2). - P. 284-294.

Riabov V., Gudima A., Wang N. et al. Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis // Frontiers in Physiology. - 2014. - Vol. 5. - P. 75. - DOI: 10.3389/fphys.2014.00075

Sakuma R., Kawahara M., Nakano-Doi A. et al. Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke // J. Neuroinflammation. - 2016. - Vol. 13(1). - 57 p. - 10.1186/ s12974-016-0523-9. DOI: 10.1186/s12974-016-0523-9

Sciumè G., Soriani A., Piccoli M. et al. CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-beta1 // Neuro-Oncology. - 2010. - Vol. 12(7). - P 701-710.

Shen Q., Wang Y, Kokovay E. et al. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions // Cell Stem Cell. - 2008. - Vol. 3(3). - P 289-300.

Simon M.P, Tournaire R., Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1 // J. Cell Physiol. - 2008. - Vol. 217. - P 809-818.

Snigireva A.V., Vrublevskaya V.V., Afanasyev V.N., Morenkov O.S. Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90a and Hsp90ß to the cell plasma membrane // Cell Adh Migr. - 2015. - Vol. 9(6). - P. 460-468.

Soulas C., Donahue R.E., Dunbar C.E. et al. Genetically Modified CD34 Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in LongTerm Repopulated Primates // Am J. Pathol. - 2009. - Vol. 174(5). - P. 1808-1817.

Stallcup W.B, You W.-K., Kucharova K. et al. NG2 proteoglycan-dependent contributions of pericytes and macrophages to brain tumor vascularization and progression // Microcirculation. - 2016. - Vol. 23(2). - P. 122-133.

Stapor PC., Sweat R.S., Dashti D.C. et al. Pericyte Dynamics during Angiogenesis: New Insights from New Identities // J. Vasc. Res. - 2014. - Vol. 51(3). - P. 163-174.

Szulzewsky F., Pelz A., Feng X. et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1 // PLoS ONE. - 2015. - Vol. 10(2). - P. 0116644. - DOI: 10.1371/journal.pone.0116644

Thomas M., Augustin H.G. The role of the Angiopoietins in vascular morphogenesis // Angiogenesis. - 2009. - Vol. 12(2). - P. 125-137.

Turrini R., Pabois A., Xenarios I. et al. TIE-2 expressing monocytes in human cancers // Oncoimmunology - 2017. - Vol. 6(4). - P. e1303585. - DOI: 10.1080/2162402X.2017.1303585

Vasile F., Dossi E., Rouach N. Human astrocytes: structure and functions in the healthy brain // Brain Struct Funct. - 2017. - Vol. 222(5). - P 2017-2029.

Walker D.G., Lue L.-F. Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains // Alzheimers Res Ther. - 2015. - Vol. 7(1). - P. 56. - DOI: 10.1186/s13195-015-0139-9

Wang P., Zhen H., Zhang J.et al. Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo // Molecular Carcinogen. - 2012. - Vol. 51. - P. 586-595.

Wang R., Chadalavada K., Wilshire J. et al. Glioblastoma stem-like cells give rise to tumour endothelium // Nature. - 2010. - Vol. 468. - P 829-833.

Winkler E.A., Bell R.D., Zlokovic B.V. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling // Mol. Neurodegener. - 2010. - Vol. 5. - P 1-32.

Wu T., Luo Q., Ouyang G. Periostin: a potent chemotac-tic factor for recruiting tumor-associated macrophage // Protein Cell. - 2015. - Vol. 6(4). - P 235-237.

Xie A.X., Petravicz J., McCarthy K.D. Molecular approaches for manipulating astrocytic signaling in vivo // Frontiers in Cellular Neuroscience. - 2015. - Vol. 9. - P 144. - DOI: 10.3389/fncel.2015.00144

Yi L., Xiao H., Xu M. et al. Glioma-initiating cells: a predominant role in microglia/macrophages tropism to glioma // J. Neuroimmunol. - 2011. - Vol. 232(12). - P. 75-82.

Yi Y., Hsieh I.-Y., Huang X. et al. Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy // Front Pharmacol. - 2016. - Vol. 7. - P 477. - 10.3389/fphar. 2016.00477. DOI: 10.3389/fphar.2016.00477

You W.-K., Yotsumoto F., Sakimura K. et al. NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function // Angiogenesis. - 2014. - Vol. 17(1). - P 61-76.

Youn J.-I., Gabrilovich D.I. The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity // Eur. J. Immunol. -2010. - Vol. 40(11). - P 2969-2975.

Zadeh G., Reti R., Koushan K. et al. Regulation of the Pathological Vasculature of Malignant Astrocytomas by Angiopoietin-1 // Neoplasia. - 2005. - Vol. 7(12). - P. 1081-1090.

Zhang B., Wang Z., Wu L. et al. Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma // PLoS ONE. - 2013. - Vol. 8(2). - P. e57114. - DOI: 10.1371/journal.pone.0057114

Zhang J., Sarkar S., Cua R. et al. A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis // Carcinogenesis. - 2012. - Vol. 33(2). - P 312-319.

Zhao J., Zhao J., Van Rooijen N., Perlman S. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-cov-infected mice // Plos Pathog. - 2009. - Vol. 5. - P. e1000636. - DOI: 10.1371/journal.ppat.1000636

Zhu T.S., Costello M.A., Talsma C.E. et al. Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer StemLike Cells // Cancer Res. - 2011. - Vol. 71(18). - P. 6061-6072.

Ziegler-Heitbrock L., Ancuta P., Crowe S. et al. Nomenclature of monocytes and dendritic cells in Blood // Blood. - 2010. - Vol. 116. - P e74. - 80. DOI: 10.1182/blood-2010-02-258558

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