Connection of metastasis-free survival in breast cancer patients and an expression vector of multidrug resistance genes in tumor during neoadjuvant chemotherapy
Vol. 70 No. 1 (2024), Articles
Vol. 70 No. 1 (2024)

Connection of metastasis-free survival in breast cancer patients and an expression vector of multidrug resistance genes in tumor during neoadjuvant chemotherapy

Articles
https://doi.org/10.37469/0507-3758-2013-59-3-334-340
Published 15.12.2013
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences; Siberian State Medical University
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences; Siberian State Medical University
Siberian State Medical University
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences; Siberian State Medical University
Research Institute of Oncology, Siberian Branch of the Russian Academy of Medical Sciences; Siberian State Medical University
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Keywords

гены множественной лекарственной устойчивости
рак молочной железы
безметастатическая выживаемость
экспрессия генов

How to Cite

, , , , , , , , & . (2013). Connection of metastasis-free survival in breast cancer patients and an expression vector of multidrug resistance genes in tumor during neoadjuvant chemotherapy. Voprosy Onkologii, 70(1), 334–340. https://doi.org/10.37469/0507-3758-2013-59-3-334-340
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Abstract

Previously, we showed the association of neoadjuvant chemotherapy (NAC) response with changing the expression vector (increase or decrease) of multidrug resistance genes (MDR) in breast tumors during chemotherapy. The aim of the present study was to evaluate the relation between changes in the expression vector of MDR genes and distant metastasis-free survival. Patients (n = 120) with breast cancer (Tj 4N 0 3M 0) treated by 2-4 cycles of NAC (CAX, FAC, and taxane regimes) and 4 cycles of adjuvant chemotherapy (FAC) were included. TaqMan-based quantitative reverse transcriptase PCR (qRT-PCR) was used to estimate the expression of the following MDR genes: АВСВ1, АВСС1, АВСС2, АВСС5. ABCG1, ABCG2, GSTP1, and MVP—in biopsies before NAC and in tumor samples after chemotherapy. Comparing the corresponding expression levels allowed us to identify the vector of expression change during NAC. The results showed that 5-year distant metastasis-free survival was 73-78% in patients with a decrease in ABCB1, ABCC2, and ABCG1 expression. The up-regulation of these genes during NAC was related to a significant decrease (up to 50-55%) in metastasis-free survival (Kaplan-Meier analysis: log-rank p value = 0.006-0.03). The association of changing the expression vector of MDR genes with metastasis-free survival did not depend on tumor size, lymph node involvement, histological form, receptor status, molecular subtype, and others clinicopathological parameters of breast cancer. The obtained data suggest that changing the expression vector of MDR genes in breast tumors during NAC may be used as a new potential prognostic marker of breast cancer. An increase in tumor expression of ABCB1. ABCC2, and ABCG1 during chemotherapy is a factor of poor prognosis, whereas down-regulation of these genes—a favorable prognostic marker.
https://doi.org/10.37469/0507-3758-2013-59-3-334-340
PDF (Русский)

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