How to Cite
Abstract
The aim of this study was to compare the diagnostic capabilities of SPECT-CT and planar osteoscintigraphy with 99m-Tc-labeled phosphates in cancer patients. There were examined 227 patients with various primary malignancies (mean age 57 years). Depending on the identified changes in the planar study patients were divided into four groups: I - no abnormalities (n = 62), II - benign changes (n = 67), III - suspected metastatic lesion (n = 41), IV - metastatic lesion (n = 57). The use of SPECT-CT in group I revealed metastatic lesion in 7 (11%) patients, in 15 (24%) patients there were additionally found benign focal changes in the skeleton. In group II metastases were found in 4 (6%) patients; it was not possible to exclude secondary lesion in 3 (4%) patients. In group III suspected metastatic lesion was excluded in 29 (71%) and confirmed in 7 (17%) patients. In group IV in 14 (25%) patients there were found non-tumor changes, the nature of the changes has not been found in 2 (4%) patients. As a result, SPECT-CT with 99m-Tc-labeled phosphates is more informative method of diagnosis of metastatic skeletal lesion than planar osteoscintigraphy. SPECT-CT application resulted in changes of conclusions of the planar scintigraphy about the nature of bone pathology in 67 (30%) cancer patients. However, in 4% the recognition of the nature of changes in the skeleton was failed.References
Веснин А.Г, Семенов И.И. Атлас лучевой диагностики опухолей опорно-двигательного аппарата. - СПб. - 2002. - C. 129-139.
Лишманов Ю.Б., Чернов В.И. Радионуклидная диагностика для практических врачей. - Томск. - 2004. - С. 280-285.
Abe K., Sasaki M., Kuwabara Y et al. Comparison of 18FDG-PET with 99mTc-HDMP scintigraphy for the detection of bone metastases in patients with breast cancer //Ann. Nucl. Med. - 2005. - Vol. 19. - P. 573-579.
Adler C.H. Knochenkrankheiten. Georg Thieme Verlag Stuttgart. - New York. - 1983. - S. 216-226.
Berrettoni B., Carter J.R. Mechanisms of cancer metastasis to bone // J Bone Joint Surg Am. - 1986. - Vol. 68. - P. 308-312.
Bonakdarpour A., Reinus W.R., Khurana J.S. Editors. Diagnostic Imaging of Musculoskeletal Diseases. A Systematic Approach // Springer Science+Business Media, LLC. - 2010. - P. 302-308.
Citrin D.L., Bessent R.G., Greig W.R. A comparison of the sensitivity and accuracy of the 99m Tc-phosphate bone scan and skeletal radiograph in the diagnosis of bone metastases // Clin Radiol. - 1977. - Vol. 28. - P. 107-117.
Dickinson F., Liddicoat A., Dhingsa R., Finlay D. Magnetic resonance imaging versus radionuclide scintigraphy for screening in bone metastases // Clin Radiol. - Aug 2000. - Vol. 55. - № 8. - P. 653.
Eustace S., Tello R., DeCarvalho V. et al. A comparison of whole-body turboSTIR MR imaging and planar 99m Tc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases // Am J Roentgenol. - 1997. - Vol. 169. - P. 1655-1661.
Evans A.J., Robertson J.F. Magnetic resonance imaging versus radionuclide scintigraphy for screening in bone metastases // Clin Radiol. - 2000. - Vol. 55. - № 8. - P. 653-654.
Galasko C.S.B. Mechanisms of lytic and blastic metastatic disease of bone // Clin Orthop. - 1982. - Vol. 69. - P. 20-27.
Gold R.I., Seeger L.L., Bassett L.W., Steckel R.J. An integrated approach to the evaluation of metastatic bone disease // Radiol Clin North Am. - 1990. - Vol. 28. - № 2. - P. 471-483.
Greenspan A., Jundt G., Remagen W. Differential Diagnosis in Orthopaedic Oncology. 2nd ed. - Lippincott Williams and Wilkins. - 2007. - P. 458-478.
Jambhekar N.A., Borges A. Metastases involving bone. In: Fletcher C.D.M., Unni K.K., Mertens F. eds. // World Health Organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone Lyon: IARS Press. - 2002. - P. 334-335.
Kido D.K., Gould R., Taati F. et al. Comparative sensitivity of CT scans, radiographs, and radionuclide bone scans in detecting metastatic calvarial lesions // Radiology. - 1978. - Vol. 128. - P. 371-375.
McDougall I.R., Kriss J.P. Screening for bone metasta-ses. Are only scans necessary? // JAMA. - 1975. - Vol. 231. - P. 46-50.
Meyers S.P. MRI of Bone and Soft Tissue Tumors and Tumorlike Lesions Thieme Stuttgart - New York, 2008. - P. 1-16.
Roodman G.D. Mechanisms of bone metastasis // N Engl J Med. - 2004. - Vol. 350. - P 1655-1664.
Soderlund V. Radiological diagnosis of skeletal metastases // Eur Radiol. - 1996. - Vol. 6. - P 587-595.
Unni K.K. Dahlin’s Bone Tumors: General Aspects and Data on 11,087 Cases. 5nd ed. Lippincott - Raven. Philadelphia. - 1996. - P. 143-196.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2014