Магомедова, З. Р., Назарова, В. В., Орлова, К. В., Унгурян, В. М., & Демидов, Л. В. (2024). Лечение метастатической увеальной меланомы: обзор литературы. VOPROSY ONKOLOGII, 70(4), 606–613. https://doi.org/10.37469/0507-3758-2024-70-4-606-613

摘要

Увеальная меланома редкая внутриглазная опухоль, несмотря на все успехи в лечении первичной опухоли, более чем у 50 % пациентов развивается метастатическая форма заболевания. Увеальная меланома отличается по своим молекулярно-биологическим особенностям (другие драйверные мутации, меньшая мутационная нагрузка) от меланомы кожи, и если для меланомы кожи достигнуты определённые успехи в лечении (таргетная терапия, иммунотерапия), то для увеальной меланомы продолжаются поиски новых мишеней и подходов. В статье приведены исследования, отражающие эффективность и безопасность основных системных и локальных методов лечения, а также набирающих в последнее время популярность комбинированных подходов в лечении метастатической увеальной меланомы.

https://doi.org/10.37469/0507-3758-2024-70-4-606-613

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