Ключевые слова
Как цитировать
Аннотация
В течение жизни человек подвергается воздействию различных ксенобиотиков, одним из биологических эффектов которых является генотоксическое действие, приводящее к возникновению онкогенных мутаций. Мутагенные и промутагенные вещества могут быть детоксицированы соответствующими ферментами биотрансформации ксенобиотиков, однако в случае изменения энзиматической активности последних «обезвреживание» мутагенов происходит замедленными темпами. В обзоре рассматриваются полиморфные гены ферментов второй фазы биотрансформации ксенобиотиков семейства GSTs и представлены данные современной литературы о роли GSTM и GSTT в онкогенезе и развитии гемобластозов. Поиск научной литературы осуществлялся по базам данных PubMed и Cyber Leninka.
Библиографические ссылки
Berger A.H., Knudson A.G., Pandolfi P.P. A continuum model for tumour suppression // Nature. - 2011. - Vol. 476 (7359). - Р 163-169.
Wang L.H., Wu C.F., Rajasekaran N., Shin Y.K. Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview // Cell Physiol Biochem. - 2018. - Vol. 51 (6). - Р 2647-2693.
Чурносов М.И., Полякова И.С., Пахомов С.П., Орлова В.С. Молекулярные и генетические механизмы биотрансформации ксенобиотиков // Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. - 2011. - Т 15 (16 (111)). - С. 223-228.
Могиленкова Л.А., Рембовский В.Р Роль генетического полиморфизма и различия в детоксикации химических веществ в организме человека // Гигиена и санитария. - 2016. - Т. 95 (3). - С. 255-262. - doi: 10.18821/0016-9900-2016-95-3-255-262.
Корчагина Р.П., Осипова Л.П., Вавилова Н.А. и др. Полиморфизм генов биотрансформации ксенобиотиков GSTM1, GSTT1, CYP2D6, вероятных маркеров риска онкологических заболеваний, в популяциях коренных этносов и русских северной Сибири // Вавиловский журнал генетики и селекции. - 2011. - Т. 15. - № 3. - C. 448-461.
Gong M., Dong W., Shi Z. et al. Genetic polymorphisms of GSTM1, GSTT1, and GSTP1 with prostate cancer risk: a meta-analysis of 57 studies // PLoS One. - 2012. - Vol. 7 (11). - e50587. - doi: 10.1371/journal. pone.0050587.
Klusek J., G uszek S., Klusek J. GST gene polymorphisms and the risk of colorectal cancer development // Contemp Oncol (Pozn). - 2014. - Vol. 18 (4). - P 219-221. - doi: 10.5114/wo.2014.41388.
Pljesa-Ercegovac M., Matic M. GSTM1 (Glutathione Transferase M1) // Atlas Genet Cytogenet Oncol Haematol. - 2016. - Vol. 20 (1). - P 7-13. - https://doi. org/10.4267/2042/62504.
Lo H.W., Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance // Curr Opin Pharmacol. - 2007. - Vol. 7 (4). - P 367374. - doi: 10.1016/j.coph.2007.06.009.
Wu W., Peden D., Diaz-Sanchez D. Role of GSTM1 in resistance to lung inflammation // Free Radic Biol Med. - 2012. - Vol. 53 (4). - P. 721-729. - doi: 10.1016/j.freeradbiomed.2012.05.037.
Piacentini S., Polimanti R., Porreca F. et al. GSTT1 and GSTM1 gene polymorphisms in European and African populations // Mol Biol Rep. - 2011. - Vol. 38 (2). - P 1225-1230. - doi: 10.1007/s11033-010-0221-0.
Garte S., Gaspari L., Alexandrie A.K. et al. Metabolic gene polymorphism frequencies in control populations // Cancer Epidemiology Biomarkers & Prevention. - 2001. - Vol. 10. - P. 1239-1248. - https://cebp.aacrjour-nals.org/content/cebp/10/12/1239.full.pdf.
Фетисова И.Н., Межинский С.С., Чаша Т.В. и др. Полиморфизм генов системы детоксикации // Вестник ИвМА. - 2014. - Т. 19. - № 4. - С. 50-58.
He F., Liu C., Zhang R. et al. Association between the Glutathione-S-transferase T1 null genotype and esophageal cancer susceptibility: a meta-analysis involving 11,163 subjects // Oncotarget. - 2018. - Vol. 9 (19). - P 15111-15121. - doi: 10.18632/oncotarget.24534.
Adibhesami G., Shahsavari G.R., Amiri A. et al. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms and Lung Cancer Risk among a Select Group of Iranian People // Asian Pac J Cancer Prev. - 2018. - Vol. 19 (10). - P 2921-2927. - doi: 10.22034/APJCP2018.19.10.2921.
Yu P, Kusuma J.D., Suarez M.A.R., Shiao S.PK. Correction: Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: a meta-prediction of worldwide populations // Oncotarget. - 2018. - Vol. 9 (90). - P 36251. - doi: 10.18632/oncotarget.26388.
Chen D.K., Huang W.W., Li L.J. et al. Glutathione S-trans-ferase M1 and T1 null genotypes and bladder cancer risk: A meta-analysis in a single ethnic group // J Cancer Res Ther. - 2018. - Vol. 14 (Supplement). - S993-S997. - doi: 10.4103/0973-1482.191067.
Albarakati N., Khayyat D., Dallol A. et al. The prognostic impact of GSTM1/GSTP1 genetic variants in bladder Cancer // BMC Cancer. - 2019. - Vol. 19 (1). - P 991. - doi: 10.1186/s12885-019-6244-6.
Safarinejad M.R., Shafiei N., Safarinejad S.H. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran // Prostate Cancer Prostatic Dis. - 2011. - Vol. 14 (2). - P. 105-113. - doi: 10.1038/ pcan.2010.54.
Economopoulos K.P, Sergentanis T.N. GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis // Eur J Cancer. - 2010. - Vol. 46 (9). - P. 1617-1631. - doi: 10.1016/j.ejca.2010.02.009.
Darazy M., Balbaa M., Mugharbil A. et al. CYP1A1, CY-P2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese // Genet Test Mol Biomarkers. - 2011. - Vol. 15 (6). - P 423-429. - doi: 10.1089/gtmb.2010.0206.
Wang B., Huang G., Wang D. et al. Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis // J Hepatol. - 2010. - Vol. 53 (3). - P. 508-518. - doi: 10.1016/j.jhep.2010.03.026.
Liu K., Zhang L., Lin X. et al. Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC) in Chinese population evaluated by an updated systematic meta-analysis // PLoS One. - 2013. - Vol. 8 (2). - e57043. - doi: 10.1371/journal. pone.0057043.
Zhang Z.J., Hao K., Shi R. et al. Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis // Am J Epidemiol. - 2011. - Vol. 173 (8). - P. 847-857. - doi: 10.1093/aje/kwq480.
Li J.Y, Huang L.N., Xue H.L. et al. Glutathione S-transferase mu-1, glutathione S-transferase theta-1 null genotypes, and oral cancer risk: A meta-analysis in the Chinese population // J Cancer Res Ther. - 2018. - Vol. 14 (Supplement). - S1052-S1056. - doi: 10.4103/09731482.199786.
D’ Mello S., Bavle R.M., Paremala K. et al. The synergy of tobacco and alcohol and glutathione S-transferase 0 1 gene deletion and oral squamous cell carcinoma // J Oral Maxillofac Pathol. - 2016. - Vol. 20 (3). - P. 348-353. - doi: 10.4103/0973-029X.190898.
Wang J., Wu D., Sun A. Effects of GST null genotypes on individual susceptibility to leukemia: A meta-analysis // Exp Mol Pathol. - 2019. - Vol. 108. -P. 137-142. - doi: 10.1016/j.yexmp.2019.01.004.
Chen H.C., Hu W.X., Liu Q.X. et al. Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility // Eur J Cancer Prev. - 2008. - Vol. 17 (3). - P. 251-258. - doi: 10.1097/CEJ.0b013e3282b72093.
He H.R., You H.S., Sun J.Y et al. Glutathione S-transfer-ase gene polymorphisms and susceptibility to acute myeloid leukemia: meta-analyses // Jpn J Clin Oncol. - 2014. - Vol. 44 (11). - P. 1070-1081. - doi: 10.1093/ jjco/hyu121.
Gra O.A., Glotov A.S., Nikitin E.A., et al. Polymorphisms in xenobiotic-metabolizing genes and the risk of chronic lymphocytic leukemia and non-Hodgkin’s lymphoma in adult Russian patients // Am. J. Hematol. - 2008. - Vol. 83 (4). - P. 279-287. - doi: 10.1002/ajh.21113.
Овсепян В.А., Росин В.А., Загоскина Т.П., Дьяконов Д.А. Полиморфизм генов CYP1A1, GSTM1, GSTT1 и GSTP1 и некоторые клинико-лабораторные проявления хронического лимфолейкоза // Гематол. и трансфузиол. - 2013. - Т 58. - № 2. - С. 22-28.
Bajpai P., Tripathi A.K., Agrawal D. Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia // Leuk Res. - 2007. - Vol. 31 (10). - P. 13591363. - doi: 10.1016/j.leukres.2007.02.003.
Ozten N., Sunguroglu A. Bosland M.C. Variations in glutathione-S-transferase genes influence risk of chronic myeloid leukemia // Hematol Oncol. - 2012. - Vol. 30 (3). - P. 150-155. - doi: 10.1002/hon.1018.
Muddathir A.R.M., Abdallah E.I., Khabour O.F. et al. Age-and gender-independent association of glutathione-S-transferase null polymorphisms with chronic myeloid leukemia // Bosn J Basic Med Sci. - 2019. - Vol. 19 (4). - P. 350-354. - doi: 10.17305/bjbms.2019.4176.
Rostami G., Assad D., Ghadyani F. et al. Influence of glutathione S-transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment response // Mol Genet Genomic Med. - 2019. - Vol. 7 (7). - e00717. - doi: 10.1002/mgg3.717.
Zhao T., Ma F., Yin F. Role of polymorphisms of GSTM1, GSTT1 and GSTP1 Ile105Val in childhood acute lymphoblastic leukemia risk: an updated meta-analysis // Minerva Pediatr. - 2018. - Vol. 70 (2). - P. 185-196. - doi: 10.23736/S0026-4946.17.04657-6.
Zehra A., Zehra S., Ismail M., Azhar A. Glutathione S-Transferase M1 and T1 Gene Deletions and Susceptibility to Acute Lymphoblastic Leukemia (ALL) in adults // Pak J Med Sci. - 2018. - Vol. 34 (3). - P. 666-670. - doi: 10.12669/pjms.343.14911.
Farasani A. Genetic variants of glutathione S-transferase and the risk of acute myeloid leukemia in a Saudi population // Saudi J Biol Sci. - 2019. - Vol. 26 (7). - P. 1525-1530. - doi: 10.1016/j.sjbs.2018.12.011. Al-Achkar W., Azeiz G., Moassass F., Wafa A. Influence of CYP1A1, GST polymorphisms and susceptibility risk of
Salinas-Sanchez A.S., Sanchez-Sanchez F., Donate-More-no M.J. et al. Polymorphic deletions of the GSTT1 and GSTM1 genes and susceptibility to bladder cancer // BJU Int. - 2011. - Vol. 107 (11). - P. 1825-1832. - doi: 10.1111/j.1464-410X.2010.09683.x.
Safarinejad M.R., Safarinejad S., Shafiei N., Safarinejad S. Association of genetic polymorphism of glutathione S-transferase (GSTM1, GSTT1, GSTP1) with bladder cancer susceptibility // Urol Oncol. - 2013. Vol. 31 (7). - P. 1193-203. - doi: 10.1016/j.urolonc.2011.11.027.
Liu D., Liu Y, Ran L. et al. GSTT1 and GSTM1 polymorphisms and prostate cancer risk in Asians: a systematic review and meta-analysis // Tumour Biol. - 2013. - Vol. (5). - P. 2539-2544. - doi: 10.1007/s13277-013-0778-z.
Martnez C., Martn F., Fernndez J.M. et al. Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans // Pharmacoge-nomics. - 2006. - Vol. 7 (5). - P. 711-718. - doi: 10.2217/14622416.7.5.711.
Saxena A., Dhillon V.S., Raish M. et al. Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population // Breast Cancer Res Treat. - 2009. - Vol. 115 (3). - P. 537-543. - doi: 10.1007/s10549-008-0098-y.
Sergentanis T.N., Economopoulos K.P. GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis // Breast Cancer Res Treat. - 2010. - Vol. 121 (1). - P. 195-202. - doi: 10.1007/s10549-009-0520-0.
Saravani S., Miri-Moghaddam M., Bazi A., Miri-Moghad-dam E. Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran // Asian Pac J Cancer Prev. - 2019. - Vol. 20 (6). - P. 1921-1926. - doi: 10.31557/APJCP.2019.20.6.1921.
Ntais C., Polycarpou A., Ioannidis J.P. Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis // Cancer Epidemiol Biomarkers Prev. - 2005. - Vol. 14 (1). - P. 176-181. - Available at: https://cebp.aacrjournals. org/content/14/1/176.full-text.pdf.
Garc a-Gonzlez M.A., Quintero E., Bujanda L. et al. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype // Mutagenesis. - 2012. - Vol. 27 (6). - P. 771-777. - doi: 10.1093/mutage/ges049.
Matic M., Pekmezovic T., Djukic T. et al. GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study // Urol Oncol. - 2013. - Vol. 31 (7). - P. 1184-1192. - 49 doi: 10.1016/j.urolonc.2011.08.005. chronic myeloid leukemia in Syrian population // Med Oncol. - 2014. - Vol. 31 (5). - P. 889. - doi: 10.1007/ s12032-014-0889-4.
Weich N., Ferri C., Moiraghi B. et al. GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with chronic myeloid leukemia risk and treatment response // Cancer Epidemiol. - 2016. - Vol. 44. - P. 16-21. - doi: 10.1016/j.canep.2016.07.008.
Bhat G., Bhat A., Wani A. et al. Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population // Asian Pac J Cancer Prev. - 2012. - Vol. 13 (1). - P. 69-73. - doi: 10.7314/apjcp.2012.13.1.069.
Kassogue Y, Dehbi H., Quachouh M. et al. Association of glutathione S-transferase (GSTM1 and GSTT1) genes with chronic myeloid leukemia // Springerplus. - 2015. - Vol. 4. - P. 210. - doi: 10.1186/s40064-015-0966-y.
Ovsepyan V.A., Tregubova E.V., Luchinin A.S., Minaeva N.V. Gene Polymorphism of Xenobiotic Biotransformation Enzymes in Patients with Classical Ph-Negative Myeloproliferative Neoplasms // Bull Exp Biol Med. - 2019. - Vol. 167 (6). - P. 767-770. - doi: 10.1007/s10517-019-04619-5.
Banescu C., Iancu M., Trifa A.P. et al. From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro-198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia // Oxid Med Cell Longev. - 2016. - Vol. 2016. - P. 2536705. - doi: 10.1155/2016/2536705.
Nasr A.S., Sami R.M., Ibrahim NY, Darwish D.O. Glutathione S transferase (GSTP 1, GSTM 1, and GSTT 1) gene polymorphisms in Egyptian patients with acute myeloid leukemia // Indian J Cancer. - 2015. - Vol. 52 (4). - P. 490-495. - doi: 10.4103/0019-509X.178408.
Das P., Shaik A.P., Bammidi V.K. Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT 1) gene polymorphisms and risk of acute myeloid leukemia // Leuk Lymphoma. - 2009. - Vol. 50 (8). - P. 1345-1351. - doi: 10.1080/10428190903003236.
Davies S.M., Robison L.L., Buckley J.D. et al. Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children’s Cancer Group study // Cancer Epidemiol Biomarkers Prev. - 2000. - Vol. 9 (6). - P. 563-566. - Available at: https://cebp.aacrjournals. org/content/9/6/563.full-text.pdf.
Joseph T, Kusumakumary P., Chacko P. et al. Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT 1 and susceptibility to acute lymphoblastic leukaemia in Indian children // Pediatr Blood Cancer. - 2004. - Vol. 43 (5). - P. 560-567. - doi: 10.1002/pbc.20074.
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.
© АННМО «Вопросы онкологии», Copyright (c) 2020