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Abstract
Throughout life, a person is exposed to various xenobiotics, one of the biological effects of which is the genotoxic effect, leading to the occurrence of oncogenic mutations. Mutagenic and promutagenic substances can be detoxified with the corresponding xenobiotic biotransformation enzymes, however, if the enzymatic activity of the latter changes, the neutralization of the mutagens occurs at a slower pace. The review discusses the polymorphic genes of enzymes of the second phase of the biotransformation of xenobiotics of the GSTS family and presents modern literature data on the role of GSTM and GSTT in oncogenesis and the development of hemoblastoses. The search of scientific literature was carried out using the PubMed and СyberLeninka databases.References
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