Эволюционное развитие технологий лучевой терапии местнораспространенного рака шейки матки
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Ключевые слова

местнораспространенный рак шейки матки
дистанционная лучевая терапия
брахитерапия
эволюция технологий лучевой терапии

Как цитировать

Солодкий , В. А., Титова, В. А., & Паньшин , Г. А. (2023). Эволюционное развитие технологий лучевой терапии местнораспространенного рака шейки матки . Вопросы онкологии, 69(1), 15–23. https://doi.org/10.37469/0507-3758-2023-69-1-15-23

Аннотация

За последние два десятилетия парадигмы лучевой терапии полностью перешли от двумерного подхода (2D), основанного исключительно на анатомических костных ориентирах, к трехмерному (3D) индивидуальному дозиметрическому планированию под визуальным контролем, принимая во внимание различия в размере, положении опухоли и органов риска (ОР) для более точного подведения очаговых доз к клиническим мишеням с одновременным  максимальным щажением ОР. В данной статье  кратко представлены достижения в области дистанционной лучевой терапии (ДЛТ) и автоматизированной брахитерапии (БТ) для лечения                                       местнораспространенного рака шейки матки. При этом, акцентировано внимание на исторической эволюции от технологий 2D-лучевой терапии к 3D-конформной лучевой терапии (3D CRT) с последующим переходом  к лучевой терапии с модулированной интенсивностью (IMRT), которая в настоящее время становится стандартом планирования и реализации ДЛТ.  Обсуждены достижения БТ, в частности, эволюция от манчестерской системы БТ в условиях низкой мощности дозы излучения до внедряемой в настоящее время адаптивной БТ под трехмерным визуальным контролем (3D-IGABT). В этом контексте уделено внимание недавно проведенным крупным когортным исследованиям, которые показали значительное улучшение местного контроля (МК) и снижение токсичности, связанной с применением технологии 3D-IGABT. Наконец, кратко отмечены и  другие технологические достижения в лучевой терапии инвазивного местнораспространенного рака шейки матки.

https://doi.org/10.37469/0507-3758-2023-69-1-15-23
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Просмотров: 209
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