Vol. 66 No. 4 (2020), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 66 No. 4 (2020)

HIGH-RESOLUTION ANORECTAL MANOMETRY IN TESTING ANORECTAL FUNCTION AFTER COMBINATION TREATMENT FOR RECTAL CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2020-66-4-385-390

Published 01.04.2020

Oleg Kit⁺⁻
Yuriy Gevorkyan⁺⁻
Natalya Soldatkina⁺⁻
Yevgeniy Kolesnikov⁺⁻
Mikhail Averkin⁺⁻
Marina Gusareva⁺⁻
Dmitriy Kharagezov⁺⁻
Andrey Dashkov⁺⁻
Ellada Mirzoyan⁺⁻

Oleg Kit

Rostov Research Institute of Oncology

Yuriy Gevorkyan

Rostov Research Institute of Oncology

Natalya Soldatkina

Rostov Research Institute of Oncology

Yevgeniy Kolesnikov

Rostov Research Institute of Oncology

Mikhail Averkin

Rostov Research Institute of Oncology

Marina Gusareva

Rostov Research Institute of Oncology

Dmitriy Kharagezov

Rostov Research Institute of Oncology

Andrey Dashkov

Rostov Research Institute of Oncology

Ellada Mirzoyan

Rostov Research Institute of Oncology

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PDF (Русский)

Keywords

HIGH-RESOLUTION ANORECTAL MANOMETRY
RECTAL CANCER

How to Cite

Kit, O., Gevorkyan, Y., Soldatkina, N., Kolesnikov, Y., Averkin, M., Gusareva, M., Kharagezov, D., Dashkov, A., & Mirzoyan, E. (2020). HIGH-RESOLUTION ANORECTAL MANOMETRY IN TESTING ANORECTAL FUNCTION AFTER COMBINATION TREATMENT FOR RECTAL CANCER. Voprosy Onkologii, 66(4), 385–390. https://doi.org/10.37469/0507-3758-2020-66-4-385-390

Abstract

The purpose of the study was to evaluate anorectal function with high-resolution anorectal manometry in patients receiving combination treatment for rectal cancer. Material and methods. We analyzed literature data (PubMed, Scopus, eLIBRARY databases) and our treatment outcomes in 50 rectal cancer patients receiving combination or surgical treatment at Rostov Research Institute of Oncology. Results. The mean anal resting pressure was 1.8 times lower, and the maximal anal squeeze pressure was 1.5 times lower in patients after combination treatment, compared to surgical treatment (p<0.05). 3 months after combination treatment with prolonged radiotherapy, contractile properties of the internal sphincter were decreased in 83.3%, of the external sphincter - in 26.7% of patients. Fatigue rate of external sphincter muscles was increased in 17 (56.7%) patients of this group. We observed a correlation between some anorectal manometry data and the LARS score: in both groups, patients with the maximal LARS score showed the lowest mean anal resting pressure, compared to patients with minimal and average LaRs scores (p<0.05). Conclusion. Due to negative effect of radiation therapy on the anorectal function, careful selection of patients who will benefit from radiation therapy is very important, as well as identification of patients with a high risk of radiation-induced functional problems and development of rehabilitation programs for patients treated for rectal cancer.

https://doi.org/10.37469/0507-3758-2020-66-4-385-390

##article.numberofdownloads## 67

##article.numberofviews## 324

PDF (Русский)

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