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Abstract
Treatment of ovarian cancer remains an important problem in practical oncology due to the increase in morbidity and mortality from this disease.
The aim is to summarize the available literature data on the molecular mechanisms of the participation of various proteins of autophagy and apoptosis in the development, progression, formation of chemoresistance and in the assessment of the prognosis of epithelial ovarian cancer.
Materials and methods. The search for information was carried out in the materials of the databases Medline, Cochrane Library, Elibrary, NCBI, RSCI, instructions for the medical use of drugs, using keywords in the title. Used 39 articles to write this systematic review.
Results. The review examines the molecular mechanisms of autophagy and apoptosis involved in the progression of ovarian cancer and in the formation of resistance to anticancer drug therapy. It has been shown that modulation of autophagy and apoptosis can change the effectiveness of drug treatment for this tumor.
Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian cancer and the formation of resistance to antitumor treatment, further study is required and the search for new molecular targets for their modulation is required.
References
International agency for research in cancer. World health organization // Source Globocan 2018. https: // doi: gco.iarc.fr/today/fact-sheets-cancers (дата обращения: 10.11.2020).
National cancer institute. Statistic in ovarian cancer, survival by stage. 2020. URL: https://seer.cancer.gov/statfacts/html/ovary.html (дата обращения: 10.11.2020).
Каприн А.Д., Старинский В.В. Злокачественные новообразования в России в 2009, 2018 гг. (заболеваемость и смертность) / Под ред. А.Д.Каприна, В.В.Старинского, Г.В.Петровой. МНИОИ им. П.А.Герцена, филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019.
Çенков Н.К., Чечушков А.В., Кожин П.М. и др. Аутофагия как механизм защиты при окислительном стрессе // Бюллетень сибирской медицины. 2019;18(2):195–214. https: // doi: 10.20538/1682-0363-2019-2-195–214
Graham L. ACOG Releases Guidelines on Management of Adnexal Masses // Am Fam Physician. 2008;77(9):1320–1323.
Бохман Я.В. Руководство по онкогинекологии. М.: Медицина, 1989;464 [Bohman Y.V. Rukovodstvo po onkoginekologii. M.: Meditsina, 1989;464 (In Russ.)].
Карелина О.Б., Артымук Н.В., Фетисова Т.И. Факторы риcка рака яичника и возможные превентивные стратегии // Фундаментальная и клиническая медицина. 2018;3(3):91–96. https: // doi: 10.23946/2500-0764-2018-3-3-91-96 [Karelina O.B., Artymuk N.V., Fetisova T.I. Risk factors of ovarian cancer and possible preventive strategies // Fundamental'naya i klinicheskaya meditsina. 2018;3(3):91–96. https: // doi: 10.23946/2500-0764-2018-3-3-91-96. (In Russ.)].
Elmasry K, Gayther S. Epidemiology of Ovarian Cancer. In: Cancer of the Ovary. Ed. by Reznek R. Cambridge: Cambridge University Press; 2006: 1–19. https: // doi: 10.1017/CBO9780511545887.003
Вишневская Е.Е., Бохман Я.В. Ошибки в онкогинекологической практике. Минск: Выш. шк., 1994 [Vishnevskaya E.E., Bohman YaV. Oshibki v onkoginekologicheskoj praktike. Minsk: Vysh. shk.; 1994. (In Russ.)].
Харитонова Т.В., Чекалова М.А., Поддубная Т.В. Опухоли яичника (усовершенствование возможностей раннего выявления). М.; 2005 [Haritonova T.V., Chekalova M.A., Poddubnaya T.V. Opuholi yaichnika (usovershenstvovanie vozmozhnostej rannego vyyavleniya). M.; 2005. (In Russ.)].
Асатурова А.В. Современные представления о ранних этапах патогенеза рака яичников // Современные проблемы науки и образования. 2015;5. https: // doi: www.science-education.ru/ru/article/view?id=22667 [Asaturova A.V. Sovremennye predstavleniya o rannih etapah patogeneza raka yaichnikov // Sovremennye problemy nauki i obrazovaniya. 2015;5. https: // doi: www.science-education.ru/ru/article/view?id=22667 (In Russ.)].
Vaughan S, Coward JI, Bast Jr.RC et al. Rethinking Ovarian Cancer: Recommendations for Improving Outcomes // Nat Rev Cancer. 2011;11(10):719–725. https: // doi: 10.1038/nrc3144
Galluzzi L, Vitale I, Abrams J et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 // Cell Death Differ. 2012;19:107–120. https: // doi: 10.1038/cdd.2011.96
Yang JS, Hsu JW, Park SY et al. GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis // Nature. 2018;561(7722):263–267. https: // doi: 10.1038/s41586-018-0475-6
Дворяшина И.А., Великородная Ю.И., Почепцов А.Я., Федорова О.В. Современный взгляд на механизмы и классификацию клеточной гибели // Вестник Волгоградского государственного медицинского университета. 2016;3(59):137–139 [Dvoryashina I.A., Velikorodnaya Yu.I., Pocheptsov A.Y., Fedorova O.V. A modern view on the mechanisms and classification of cell death // Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2016;3(59):137–139. (In Russ.)].
Wang H, Peng Y, Wang J et al. Effect of autophagy on the resveratrol-induced apoptosis of ovarian cancer SKOV3 cells // J Cell Biochem. 2018. https: // doi: pubmed.ncbi.nlm.nih.gov/30450764 (дата обращения: 10.11.2020). https: // doi: 10.1002/jcb.28053
Harris HR, Titus LJ, Cramer DW, Terry KL. Long and irregular menstrual cycles, polycystic ovary syndrome, and ovarian cancer risk in a population-based case-control study // Int J Cancer. 2017;140(2):285–291. https: // doi: 10.1002/ijc.30441
Stover EH, Baco MB, Cohen O. et al. Pooled genomic screens identify anti-apoptotic genes as targetable mediators of chemotherapy resistance in ovarian cancer // Mol Cancer Res. 2019;17(11):2281–2293. https: // doi: 10.1158/1541-7786.MCR-18-1243
Klionsky DJ, Abdelmohsen K, Abe A et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) // Autophagy. 2016;12(1):1–222. https: // doi: 10.1080/15548627.2015.1100356
Orfanelli T, Jeong JM, Doulaveris G et al. Involvement of autophagy in cervical, endometrial and ovarian cancer // J Cancer. 2014;135(3):519–528. https: // doi: 10.1002/ijc.28524
Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms // J Pathol. 2010;221(1):3–12. https: // doi: 10.1002/path.2697
Titone R, Morani F, Follo C et al. Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer // Biomed Res Int. 2014;343542. https: // doi: 10.1155/2014/343542
Hengartner MO. The biochemistry of apoptosis // Nature. 2000;407(6805):770–776.
Yoshii SR, Mizushima N. Monitoring and Measuring Autophagy // Int J Mol Sci. 2017;18(9):1865. https: // doi: 10.3390/ijms18091865
Wei Y, Pattingre S, Sinha S et al. JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy // Mol Cell. 2008;30(6):678–688. https: // doi: 10.1016/j.molcel.2008.06.001
Yang JS, Hsu JW, Park SY et al. GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis // Nature. 2018;561(7722):263–267. https: // doi: 10.1038/s41586-018-0475-6
Mizushima N, Yoshimorim T, Levine B. Methods in Mammalian Autophagy // Research. Cell. 2010;140(3):313–326. https: // doi: 10.1016/j.cell.2010.01.028
Yang X, Yu D-D, Yan F et al. The role of autophagy induced by tumor microenvironment in different cells and stages of cancer // Cell Biosci. 2015;5:14. https: // doi: 10.1186/s13578-015-0005-2
Valente G, Morani F, Nicotra G et al. Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer // Biomed Res Int. 2014;2014:462658. https: // doi: 10.1155/2014/462658
Zhao Z, Xue J, Zhao X. et al. Prognostic role of autophagy-related proteins in epithelial ovarian cancer: a meta-analysis of observational studies // Minerva Med. 2017;108(3):277–286. https: // doi: 10.23736/S0026-4806.16.04767-4
Correa RJ, Valdes YR, Shepherd TG, DiMattia GE. Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro // J Ovarian Res. 2015;8:52. https: // doi: 10.1186/s13048-015-0182-y
Peracchio C, Alabiso O, Valente G, Isidoro C. Involvement of autophagy in ovarian cancer: a working hypothesis // Journal of Ovarian Research. 2012;5(1):22. https: // doi: 10.1186/1757-2215-5-22
Wang Y, Yu H, Zhang J et al. Anti-tumor effect of emodin on gynecological cancer cells // Cell Oncol (Dordr). 2015;38(5):353–363. https: // doi: 10.1007/s13402-015-0234-8
Zervantonakis IK, Iavarone C, Chen HY et al. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response // Nat Commun. 2017;8(1):365. https: // doi: 10.1038/s41467-017-00263-7
Хохлова С.В. Фальстарты в лечении рецидивов: оптимальное наблюдение за больными после первой линии ХТ / Мат. 3-й Международной междисциплинарной конф. «Рак яичников». Москва 25–26 марта 2016 г. М., 2016:22–28.
Vergote I, von Moos R, Manso L et al. Tumor Treating Fields in combination with paclitaxel in recurrent ovarian carcinoma: Results of the INNOVATE pilot study // Gynecol Oncol. 2018;150(3):471–477. https: // doi: 10.1016/j.ygyno.2018.07.018
Qiu S, Sun L, Zhang Y, Han S. Downregulation of BAG3 attenuates cisplatin resistance by inhibiting autophagy in human epithelial ovarian cancer cells // Oncol Lett. 2019;18(2):1969–1978. https: // doi: 10.3892/ol.2019.10494
Zhan L, Zhang Y, Wang W et al. Autophagy as an emerging therapy target for ovarian carcinoma // Oncotarget. 2016;7(50):83476–83487. https: // doi: 10.18632/oncotarget.13080
Choudhary GS, Al-Harbi S, Almasan A Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis // Methods Mol Biol. 2015;1219:1–9. https: // doi: 10.1007/978-1-4939-1661-0_1
An Y, Bi F, You Y, Liu X, Yang Q. Development of a Novel Autophagy-related Prognostic Signature for Serous Ovarian Cancer // J Cancer. 2018 Oct 18;9(21):4058–4071. https: // doi: 10.7150/jca.25587. PMID: 30410611;PMCID: PMC6218776
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