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Abstract
Purpose. The purpose of the current study was the search for evaluation criterion for the radiosensitivity of bone metastases of various origins.
Materials and methods. The first part of the study presents a modern classification of pain, method of its evaluation, mechanisms and features of metastatic bone pain. The radiobiological patterns of pain relief in low-dose anti-inflammatory radiation therapy were also considered. The analysis of these features testifies in favor of the antitumor mechanism of pain relief in high-dose irradiation. To identify the relationship between pain and other clinical symptoms, 810 cases of bone metastases of various localization and morphology were analyzed.
Results. The severity of pain directly correlates with gender, lesion length and little affected by the presence of pathological fracture. The intensity of pain does not depend on the primary tumor and bone metastases localization and does not correlate with the presence of neurological deficit.
Conclusion. Completeness and persistence of the analgesic effect may reflect the real radiosensitivity of bone metastases, but taking into account the patient's gender and lesion length in the irradiated area.
References
Abrams H, Spiro R, Goldstein N. Metastases in carcinoma. Analysis of 1000 autopsied cases // Cancer. 1950;3:74–85. https: // doi: 10.1002/1097-0142(1950)3:1<74::aid-cncr2820030111>3.0.co;2-7
Disibio G, French S. Metastatic patterns of cancers. Results from a large autopsy study // Arch Pathol Lab Med. 2008;132 (6):931–939. https: // doi: 10.1043/1543-2165(2008)132[931:MPOCRF]2.0.CO;2
Sze WM, Shelley M, Held I et al. Palliation of metastatic bone pain: singl fraction versus multiple-fraction radiotherapy — a systematic review of randomised trials // Clin Oncol. 2003;15(6):345–352. https: // doi: 10.1016/S0936-6555(03)00113-4
Wu J, Wong R, Johnston M et al. Meta-analisis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases // Int J Radiat Oncol Biol Phys. 2003;55(3):594–605. https: // doi: 10.1016/S0360-3016(02)04147-0
Takahashi Т, Nishimura К, Yamano T, Gika M. Role of Palliative Radiotherapy for Bone Metastasis // J Palliat Care Med. 2014;4:171. https: // doi: 10.4172/2165-7386.1000171
Eisenhauer EA, Therasse P, Bogaerts J et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) // Eur J Cancer. 2009;45:228–47. https: // doi: 10.1016/j.ejca.2008.10.026
Количественные закономерности и дозиметрия в радиобиологии. Доклад МКРЕ 30 / Под ред. И.Б.Керим-Маркуса. М: Энергоатомиздат, 1984 [Quantitative concepts and dosimetry in radiobiology. ICRU REPORT 30, Issues April 15, 1979].
Bentzen SM. Radiation dose-response relationships. In Basic Clinical Radiobiology, ed. by M.C.Joiner and A.J. van der Kogel, CRC Press Taylor & Francis Group, 2019:44–53.
Cox J, Stetz B, Pajak T. Toxicity criteria of the Radiatioin Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) // Int J Radiation Oncology Biol Phys. 1995;31(5):1341–1346. https: // doi: 10.1016/0360-3016(95)00060-C
Кукушкин М.Л. Механизмы развития хронической боли. Подходы к профилактике и лечению // Consilium Medicum. 2017;19(2):110–117 [Kukushkin M.L. Mechanisms of cronic pain development. Approches to prevention and treatment // Consilium Medicum. 2017;19(2):110–117 (In Russ.)].
Bennett MI, Kaasa S, Barke A et al. IASP Taskforce for the Classification of Chronic Pain. The IASP classification of chronic bone pain for ISD-11: chronic cancer-related pain // Pain. 2019 Jan;160(1):38–44. https: // doi: 10.1097/j.pain.0000000000001363
Jensen MP. The validity and reliability of pain measures in adults with cancer // J Pain. 2003;4:2–21. https: // doi: 10.1054/jpai.2003.1
Caraceni A, Cherny N, Fainsinger R et al. Pain measurement tools and methods in clinical research in palliative care: recommendations of an Expert Working Group of the European Association of Palliative Care // J Pain Symptom Manage. 2002;23:239–255. https: // doi: 10.1016/s0885-3924(01)00409-2
Hjermstad MJ, Fayers PM, Haugen DF et al. European Palliative Care Research Collaborative (EPCRC). Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review // J Pain Symptom Manage. 2011 Jun;41(6):1073–93. https: // doi: 10.1016/j.jpainsymman.2010.08.016
Svensson E. Concordance between ratings using different scales for the same variable // Stat Med. 2000;19:3483–3496. https: // doi: 10.1002/1097-0258(20001230)19:24<3483::aid-sim786>3.0.co;2-a
Skovlund E, Flaten O. Response measures in the acute treatment of migraine // Cephalalgia. 1995;15:519–522. https: // doi: 10.1046/j.1468-2982.1995.1506519.x
Figura N, Smith J, Yu H. Mechanisms of, and Adjuvants for, Bone Pain // Hematol Oncol Clin N Am. 2018;32:447–458. https: // doi: 10.1016/j.hoc.2018.01.006
Кривошапкин А.Л. Физиология боли. Современные концепции и механизмы. Обзор иностранной литературы. https: // doi: www.painstady.ru/matls/review/fizio.htm [Krivoshapkin A.L. Physiologia of pain. Currentconcepts and mechanisms. https: // doi: www.painstady.ru/matls/review/fizio.htm (In Russ.)].
Zajaczkowska R, Kocot-Kepska M, Leppert W, Wordliczek J. Bone pain in cancer patients: mechanisms and current treatment // Int J Mol Sci. 2019;20: 6047–66. https: // doi: 10.3390/ijms20236047
Falk S, Dickenson A. Pain and nociception: mechanism of cancer-induced bone pain // J Clin Oncology. 2014;32(1):1647–1654. https: // doi: 10.1200/JCO.2013.51.7219
Bowsher D. Contralateral mirror-image pain following anterolateral cordotomy // Pain. 1988 Apr;33(1):63–5. https: // doi: 10.1016/0304-3959(88)90204-7
Овсянников В.Г., Бойченко А.Е., Алексеев В.В., Алексеева Н.С. Инициальные механизмф формирования боли // Журнал фундаментальной медицины и биологии. 2015;3:4–12 [Ovsyannikov V.G., Boichenko A.E., Alekseev V.V., Alekseeva N.S. The initial formation and mechanisms of the pain // Jornal of fundamental medicine and biology. 2015;3:4–12 (In Russ.)].
Urch C. The pathophysiology of cancer-induced bone pain: current understanding // Palliative Medicine. 2004;18: 267–274. https: // doi: 10.1191/0269216304pm887ra
Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer // Clin Cancer Res. 2010;16:2927–2931. https: // doi: 10.1158/1078-0432.CCR-09-2329
Sun YX, Fang M, Wang J, Cooper CR, Pienta KJ, Taichman R.S. Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells // Prostate. 2007;67:61–73. https: // doi: 10.1002/pros.20500
Wang L, Song L, Li J et al. Bone sialoprotein-αvβ3 integrin axis promotes breast cancer metastasis to the bone // Cancer Sci. 2019 Oct;110(10):3157–3172. https: // doi: 10.1111/cas.14172
Jimenez-Andrade JM, Bloom AP, Stake JI et al. Pathological sprouting of adult nociceptors in chronic prostate cancer–induced bone pain // J Neurosci. 2010;30:14649–14656. https: // doi: 10.1523/JNEUROSCI.3300-10.2010
Mercadante S, Arcuri E. Breakthrough pain in cancer patients: pathophysiology and treatment // Cancer Treat Rev. 1998;24(6):425–32. https: // doi: 10.1016/s0305-7372(98)90005-6
Yoneda T, Hiasa M, Nagata Y et al. Acidic microenvironment and bone pain in cancer-colonized bone // Bonekey Rep. 2015 May 6;4:690. https: // doi: 10.1038/bonekey.2015.58
Mantyh P. Bone cancer pain: Causes, consequences, and therapeutic opportunities // Pain. 2013;154 Suppl 1:54–62. https: // doi: 10.1016/j.pain.2013.07.044
Carrafiello G, Lagana D, Pellegrino C et al. Ablation of painful metastatic bone tumors: A systematic review // Int J Surg. 2008;6: 47–52. https: // doi: 10.1016/j.ijsu.2008.12.035
Nieder C, Pawinski A, Dalhaug A. Continuous controversy about radiation oncologists’ choice of treatment regimens for bone metastases: Should we blame doctors, cancer-related features, or design of previous clinical studies? // Radiat Oncol. 2013;8:85. https: // doi: 10.1186/1748-717X-8-85
Rödel F, Keilholz L, Herrmann M et al. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy // Int J Radiat Biol. 2007 Jun;83(6):357–66. https: // doi: 10.1080/09553000701317358
Baselet B, Sonveaux P, Baatout S, Aerts A. Pathological effect of ionizing radiation: endothelial activatiov and disfunction // Cell Mol Life Sci. 2019 Feb;76(4):699–728. https: // doi: 10.1007/s00018-018-2956-z
Schröder A, Kriesen S, Hildebrandt G, Manda K. First Insights into the Effect of Low-Dose X-Ray Irradiation in Adipose-Derived Stem Cells // Int J Mol Sci. 2019 Dec 2;20(23):6075. https: // doi: 10.3390/ijms20236075
Park S-H, Lee JE. Radiotherapy, a new treatment option for non-malignant disorders: radiobiological mechanisms, clinical applications, and radiation risk // Journal of Rheumatic Diseases. 2017;24(2):75. https: // doi: 10.4078/jrd.2017.24.2.74
Micke O, Seegenschmiedt MH. German Working Group on Radiotherapy in Germany. Consensus guidelines for radiation therapy of benign diseases: a multicenter approach in Germany // Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):496–513. https: // doi: 10.1016/s0360-3016(01)01814-4
Heyd R, Tselis N, Ackermann H et al. Radiation therapy for painful heel spurs: results of prospective randomized study // Strahlenther Onkol. 2007 Jan;183(1):3–9. https: // doi: 10.1007/s00066-007-1589-1
Ott O, Jeremias C, Gaipl US et al. Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial // Strahlenther Onkol. 2014 Jul;190(7):671–5. https: // doi: 10.1007/s00066-014-0618-0
Prokein B, Holtmann H, Hautmann MG et al. Radiotherapy of painful heel spur with two fractionation regimens: Results of a randomized multicenter trial after 48 weeks' follow-up // Strahlenther Onkol. 2017 Jun;193(6):483–490. https: // doi: 10.1007/s00066-017-1116-y
Бычкова Н.М., Хмелевский Е.В. Особенности метастатического поражения костей при различных первичных опухолях и их значение для дистанционной лучевой терапии // Онкология. Журнал им. П.А.Герцена. 2016;5(6):12–20. https: // doi: 10.17116/onkolog20165612-20
Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings // Br J Anaesth. 2013 Jul;111(1):52–8. https: // doi: 10.1093/bja/aet127
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