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Abstract
The aim. The aim of the work was to establish the organotropy of metastases of glioblastoma (glioma C6) implanted intracranially or intramuscularly, as well as to determine the diameter of the blood vessels of the microvascular network in the organs of tumor-bearing animals. (rats).
Materials and methods. The objects of the study were: the brain, organs of the thoracic and abdominal cavities in rats. The studies were carried out on histological preparations visually and morphometrically from the 3 up to 14 day after implantation of the tumor.
Results. With both methods of glioblastoma implantation, metastases in the lang were diagnosed. An increase in the proportion (%) of microvessels with a wide diameter was recorded in all the organs studied and throughout the entire duration of the experiment.
Conclusions.
The organotropy of gliobolastoma metastases does not depend on the place of its implantation. The expansion of the microvascular network in the organs of tumor carriers is considered as a phenomenon related to the process of metastasis. The expediency of lung examination for the presence of metastases in patients with diagnosed glioblastoma multiforme is discussed.
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