Keywords
How to Cite
Abstract
Introduction. The emergence of tuberculosis in individuals from high-risk groups and the active detection of the disease remains a pertinent issue in healthcare. Patients with cancer may experience decreased immunity and immunosuppressive therapy, which can lead to the progression of latent tuberculosis infection (LTBI).
Aim. To identify the presence of LTBI in patients with malignant neoplasms of various localization using the recombinant tuberculosis allergen skin test (Diaskintest®).
Materials and methods. The study examined immunological test data using the Diaskintest® test from medical records of 132 patients with verified diagnoses of malignant tumors of various localizations admitted to the Voronezh Regional TB Dispensary from 2011 to 2022 for the exclusion of active tuberculosis in the respiratory system. Among them, there were 100 (75.76 %) males and 32 (24.24 %) females aged between 44 and 86 years. The presence of LTBI in patients was confirmed by a positive reaction to the Diaskintest®.
Results. It was found that 37.1 % of patients with oncological diseases had LTBI, indicating an increased risk of tuberculosis progression. The presence of residual inactive tuberculous changes in various organs was associated with a higher occurrence of LTBI - 53.8 % compared to 30.1 % in their absence (p < 0.05).
Conclusion. When detecting and preparing for the treatment of cancer patients, it is advisable to screen them for latent tuberculosis using the Diaskintest®, followed by determining the need for preventive treatment and observation.
References
Наркевич А.Н., Корецкая Н.М., Виноградов К.А., и др. Анализ влияния социально-бытовых факторов на риск развития туберкулеза легких. Пульмонология. 2015;25(4):465-468 [Narkevich AN, Koretskaya NM, Vinogradov KA, et al. A role of social factors for risk of pulmonary tuberculosis. Russian Pulmonology. 2015;25(4):465-8 (In Russ.)]. doi:10.18093/0869-0189-2015-25-4-465-468.
Лапшина И.С., Цыбикова Э.Б., Котловский М.Ю. Группы риска заболевания туберкулезом органов дыхания среди взрослого населения Калужской области. Туберкулез и болезни легких. 2022;100(11):20-28 [Lapshina IS, Tsybikova EB, Kotlovskiy MYu. Groups at high risk of developing respiratory tuberculosis among adult population of Kaluga Oblast. Tuberculosis and Lung Diseases. 2022;100(11):20-8 (In Russ.)]. doi:10.21292/2075-1230-2022-100-11-20-28.
Cheon J, Kim C, Park EJ, et al. Active tuberculosis risk associated with malignancies: an 18-year retrospective cohort study in Korea. J Thorac Dis. 2020;12(9):4950-4959. doi:10.21037/jtd.2020.02.50.
Tezera LB, Bielecka MK, Ogongo P, et al. Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α. Elife. 2020;9:e52668. doi:10.7554/eLife.52668.
Jin C, Yang B. A case of delayed diagnostic pulmonary tuberculosis during targeted therapy in an EGFR mutant non-small cell lung cancer patient. Case Rep Oncol. 2021;14(1):659-663. doi:10.1159/000514050.
Nanthanangkul S, Promthet S, Suwanrungruang K, et al. Incidence of and risk factors for tuberculosis among cancer patients in endemic area: a regional cohort study. Asian Pac J Cancer Prev. 2020;21(9):2715-2721. doi:10.31557/APJCP.2020.21.9.2715.
Литвинов В.И. «Дремлющие» микобактерии, дормантные локусы, латентная туберкулезная инфекция. Туберкулез и социально значимые заболевания. 2016;2:5-13 [Litvinov VI. «Dormant» mycobacteria, dormant loci, latent tuberculosis infection. Tuberculosis and socially significant diseases. 2016;2:5-13 (in Russ.)]. Available from: https://www.elibrary.ru/download/elibrary_42693735_16595590.pdf.
Abdelwahab HW, Elmaria MO, Abdelghany DA, et al. Screening of latent TB infection in patients with recently diagnosed bronchogenic carcinoma. Asian Cardiovasc Thorac Ann. 2021;29(3):208-213. doi:10.1177/0218492320984881.
Yamaguchi F, Minakata T, Miura S, et al. Heterogeneity of latent tuberculosis infection in a patient with lung cancer. J Infect Public Health. 2020;13(1):151-153. doi:10.1016/j.jiph.2019.07.009.
Новицкая Т.А., Ариэль Б.М., Двораковская И.В., и др. Морфологические особенности сочетания туберкулёза и рака лёгких. Архив патологии. 2021;83(2):19-24 [Novitskaya TA, Ariel BM, Dvorakovskaya IV, et al. Morphological characteristics of pulmonary tuberculosis concurrent with lung cancer. Arkhiv Patologii (Archive of Pathology). 2021;83(3):19-24 (in Russ.)]. doi:10.17116/patol20218302119.
Abudureheman M, Simayi R, Aimuroula H, et al. Association of mycobacterium tuberculosis L-formmpb64 gene and lung cancer. Eur Rev Med Pharmacol Sci. 2019;23(1):113-120. doi:10.26355/eurrev_201901_16755.
Arrieta O, Molina-Romero C, Cornejo-Granados F, et al. Clinical and pathological characteristics associated with the presence of the IS6110 Mycobacterim tuberculosis transposon in neoplastic cells from non-small cell lung cancer patients. Sci Rep. 2022;12(1):2210. doi:10.1038/s41598-022-05749-z.
Viatgé T, Mazières J, Zahi S, et al. Tuberculose pulmonaire sous traitement par immunothérapie type anti-PD1 [Anti-PD1 immunotherapy followed by tuberculosis infection or reactivation (French.)]. Rev Mal Respir. 2020;37(7):595-601. doi:10.1016/j.rmr.2020.06.003.
Gitman M, Vu J, Nguyen T, et al. Evaluation of a routine screening program with tuberculin skin testing on rates of detection of latent tuberculosis infection and prevention of active tuberculosis in patients with multiple myeloma at a Canadian cancer centre. Curr Oncol. 2020;27(3):e246-e250. doi:10.3747/co.27.5577.
Nachiappan AC, Rahbar K, Shi X, et al. Pulmonary tuberculosis: role of radiology in diagnosis and management. radiographics. 2017;37(1):52-72. doi:10.1148/rg.2017160032.
Tamura A, Fukami T, Hebisawa A, et al. Recent trends in the incidence of latent tuberculosis infection in Japanese patients with lung cancer: A small retrospective study. J Infect Chemother. 2020;26(3):315-317. doi:10.1016/j.jiac.2019.10.018.
Слогоцкая Л.В., Синицын М.В., Кудлай Д.А. Возможности иммунологических тестов в диагностике латентной туберкулезной инфекции и туберкулеза. Туберкулёз и болезни лёгких. 2019;97(11):46-58 [Slogotskаya LV, Sinitsyn MV, Kudlаy DА, et al. Potentialities of immunological tests in the diagnosis of latent tuberculosis infection and tuberculosis. Tuberculosis and Lung Diseases. 2019;97(11):46-58 (in Russ.)]. doi:10.21292/2075-1230-2019-97-11-46-58.
Фелькер И.Г., Павленок И.В., Ставицкая Н.В., Кудлай Д.А. Латентная туберкулезная инфекция среди детей и взрослых в регионах с высокой распространенностью туберкулеза. Туберкулёз и болезни лёгких. 2023;101(1):34-40 [Felker IG, Pavlenok IV, Stavitskaya NV, Kudlay DA. Latent tuberculosis infection among children and adults in the regions with high prevalence of tuberculosis. Tuberculosis and Lung Diseases. 2023;101(1):34-40 (in Russ.)]. doi:10.58838/2075-1230-2023-101-1-34-40.
Oh CM, Roh YH, Lim D, et al. Pulmonary tuberculosis is associated with elevated risk of lung cancer in Korea: the nationwide cohort study. J Cancer. 2020;11(7):1899-1906. doi:10.7150/jca.37022.
Литвинов В.И. Латентная туберкулезная инфекция – свойства возбудителя; реакции макроорганизма; эпидемиология и диагностика (IGRA-тесты, ДИАСКИНТЕСТ® и другие подходы), лечение. М.: МНПЦБТ. 2016:196 [Litvinov VI. Latent tuberculosis infection - properties of the pathogen; macroorganism reactions; epidemiology and diagnosis (IGRA-tests, DIASKINTEST® and other approaches), treatment. - MOSCOW: MNPCBT. 2016:196 (in Russ.)].
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2023