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Abstract
Currently, cervical cancer (CC) is one of the major socially significant oncological diseases affecting women of various age groups. Concomitant chemoradiotherapy followed by radiotherapy and automated brachytherapy is the standard treatment method, primarily for locally advanced cervical cancer (LACC) with disease stages ranging from IB3 to IVA according to FIGO, and it is a highly effective therapeutic approach for many patients. It is worth noting that significant progress has been made in the treatment of CC, especially in the field of radical chemoradiotherapy for LACC, over the past two decades. In this regard, radiation therapy (RT) paradigms have shifted from a two-dimensional (2D) approach based solely on anatomical bony landmarks to a three-dimensional (3D) approach with visual control of the radiation therapy process, allowing for the delivery of increased focal radiation doses more accurately to clinical targets with maximum organ-at-risk preservation. This brief review discusses current achievements in the treatment of invasive LACC with a focus on the visualization of the therapeutic process (RT and automated brachytherapy) when using adjuvant and neoadjuvant chemotherapy and radical concurrent chemoradiotherapy. Particular attention is paid to current achievements and future research directions in the field of RT, with an emphasis on three-dimensional brachytherapy, intensity-modulated radiotherapy (IMRT) under visual control, proton RT, and immunotherapy in conjunction with concurrent chemoradiotherapy.
References
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