Vol. 69 No. 6 (2023), REVIEWS

Vol. 69 No. 6 (2023)

Possibilities of Molecular Genetic Testing of Tumor Tissue for Personalized Breast Cancer Treatment

REVIEWS

https://doi.org/10.37469/0507-3758-2023-69-6-1002-1013

Published 29.12.2023

Maria Makarova⁺⁻
Marina Nemtsova⁺⁻
Dzhennet Chekini⁺⁻
Denis Chernevskiy⁺⁻
Ekaterina Kosova⁺⁻
Elena Baranova⁺⁻
Olesya Sagaydak⁺⁻
Anastasia Krinitsina⁺⁻
Maxim Belenikin⁺⁻

Maria Makarova

Evogen LLC; Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation

https://orcid.org/0000-0003-1581-9118

Marina Nemtsova

Evogen LLC; Research Centre for Medical Genetics of N.P. Bochkov; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov of the Ministry of Health of Russian Federation

https://orcid.org/0000-0002-2835-5992

Dzhennet Chekini

Clinical hospital Lapino "Mother and Child"

https://orcid.org/0000-0001-8581-1328

Denis Chernevskiy

Evogen LLC; Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation

https://orcid.org/0000-0002-9734-017X

Ekaterina Kosova

Evogen LLC

https://orcid.org/0000-0003-4732-6748

Elena Baranova

Evogen LLC, Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russian Federation

https://orcid.org/0000-0001-9638-2303

Olesya Sagaydak

Evogen LLC

https://orcid.org/0000-0002-2534-8463

Anastasia Krinitsina

Evogen LLC

https://orcid.org/0000-0002-0653-3655

Maxim Belenikin

Evogen LLC

https://orcid.org/0000-0002-6556-163X

pdf (Русский)

Keywords

gene expression
somatic mutation profiling
driver genes
targeted therapy
breast cancer
molecular subtypes of breast cancer

How to Cite

Makarova, M., Nemtsova, M., Chekini, D., Chernevskiy, D., Kosova, E., Baranova, E., Sagaydak, O., Krinitsina, A., & Belenikin, M. (2023). Possibilities of Molecular Genetic Testing of Tumor Tissue for Personalized Breast Cancer Treatment. Voprosy Onkologii, 69(6), 1002–1013. https://doi.org/10.37469/0507-3758-2023-69-6-1002-1013

Abstract

Today, the modern genomic technologies are changing the approach to diagnostics and treatment of cancer. For example, clinical approaches to the prevention, diagnosis and treatment of breast cancer have shifted towards the use of molecular genetic and immunohistochemical testing.

The review aims to describe the possibilities of using various tumor tissue genetic testing to improve the efficacy of breast cancer treatment. The review discusses the results of application of modern molecular (The Cancer Genome Atlas) and immunohistochemical (surrogate) markers for breast cancer subtypes classification, the advantages and disadvantages of such separation are presented. The main characteristics of modern expression-based prognostic tests are presented, and the feasibility and difficulties of using next-generation sequencing, including extended multigene NGS panels in clinical practice are discussed. The review targets residents and postgraduates, geneticists and oncologists, who use the results of modern molecular genetic tests in their work.

https://doi.org/10.37469/0507-3758-2023-69-6-1002-1013

pdf (Русский)

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