Макарова, М. В., Немцова, М. В., Чекини, Д. А., Черневский, Д. К., Косова, Е. В., Баранова, Е. Е., Сагайдак, О. В., Криницына , А. А., & Беленикин, М. С. (2023). Возможности молекулярно-генетического тестирования опухолевой ткани для персонализированного подхода в лечении рака молочной железы. VOPROSY ONKOLOGII, 69(6), 1002–1013. https://doi.org/10.37469/0507-3758-2023-69-6-1002-1013

摘要

Сегодня результаты развития геномных технологий меняют подход к диагностике и лечению онкологических заболеваний. Так, клинические подходы к профилактике, диагностике и лечению рака молочной железы сместились в сторону использования молекулярно-генетической и иммуногистохимической информации.

Целью настоящего обзора является описание возможностей применения различных молекулярно-генетических исследований опухолевой ткани с целью повышения эффективности лечения рака молочной железы. В обзоре обсуждаются результаты применения современных молекулярных (The Cancer Genome Atlas) и иммуногистохимических (суррогатных) маркеров, обеспечивающих разделение РМЖ по молекулярным подтипам, приведены преимущества и недостатки такого разделения. Представлены основные характеристики современных экспрессионных прогностических тестов, обсуждается целесообразность и сложности применения высокопроизводительного секвенирования, в том числе расширенных мультигенных NGS-панелей в клинической практике. Обзор предназначен для ординаторов и аспирантов, врачей-генетиков и врачей-онкологов, использующих в своей работе результаты современных молекулярно-генетических тестов.

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