THE PROGNOSTIC VALUE OF PD-L1 EXPRESSION IN TUMOR AND IMMUNE CELLS IN SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA
PDF (Русский)

Keywords

TUMOR-INFILTRATING LYMPHOCYTES
PD1-ТЕРАПИЯ
ЭКСПРЕССИЯ PD-L1
PD-L1 EXPRESSION
PD-LIGAND 1
ORAL CAVITY CANCER
PD1-THERAPY

How to Cite

Kutukova, S., Belyak, N., Raskin, G., Mukhina, M., Manikhas, G., Yaremenko, A., Ivaskova, Y., Kuzmina, M., & Pestova, N. (2017). THE PROGNOSTIC VALUE OF PD-L1 EXPRESSION IN TUMOR AND IMMUNE CELLS IN SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA. Voprosy Onkologii, 63(5), 759–765. https://doi.org/10.37469/0507-3758-2017-63-5-759-765

Abstract

The most frequent of malignant tumor cites of the oral mucosa are tongue - 55 %, mucosa of the cheek - 12 %, the fundus of the oral cavity - 10 %, the alveolar process of the upper jaw and the hard palate - 9 %, the alveolar process of the lower jaw - 6 %, the soft palate - 2 %. Malignant tumor cells carry PD-L1 ligands on their surface and its expression level is often correlated with an unfavorable prognosis in particular for such tumors as melanoma, kidney cancer and non-small cell lung cancer. It is relevant to evaluate the correlation between overexpression of PD-L1 and overall survival in patients with malignant tumors of the oral mucosa.
https://doi.org/10.37469/0507-3758-2017-63-5-759-765
PDF (Русский)

References

Chen D.S., Irving B.A., Hodi F.S. Molecular pathways: next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1 // J. Clinical Cancer Research. - 2012. - Vol. 18. - P. 6580-6587.

D'Incecco A. et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients // British J. Cancer. - 2015. - Vol. 112. - P 95-102.

Ferris R.L. Immunology and immunotherapy of head and neck cancer // J. Clinical Oncology. - 2015. - Vol. 33. - P 3293-3304.

Konishi J. et al. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression // J. Clinical Cancer Research - 2004. - Vol. 10. - P 5094-5100.

Lipson E.J. et al. PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus and overall survival // J. Cancer Immunology Research. - 2013. - Vol. 1. - P 54-63.

Mu C.Y et al. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation // J. Medical Oncology. - 2011. - Vol. 28. - P. 682-688.

Ock C.Y et al. Pan-cancer immunogenomic perspective on the tumor microenvironment based on PD-L1 and CD8 T cell infiltration // J. Clinical Cancer Research. -2016. - Vol. 22. - P. 2261-2270.

Partlova S. et al. Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma // J. Oncoimmunology. - 2015. - Vol. 4. - e965570.

Song M. et al. PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer // PLoS One. - 2013. - Vol. 8. - e65821.

Taube J.M. et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape // Science Translation Medicine. - 2012. - Vol. 4. - 127-137.

Teng M.W., Ngiow S.F., Ribas A., Smyth M.J. Classifying cancers based on T-cell infiltration and PD-L1 // J. Cancer Research. - 2015. - Vol. 75. - P. 2139 -2145.

Vassilakopoulou M. et al. Evaluation of PD-L1 expression and associated tumor-infiltrating lymphocytes in laryngeal squamous cell carcinoma // J. Clinical Cancer Research. - 2016. - Vol. 22. - P. 704-713.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© АННМО «Вопросы онкологии», Copyright (c) 2017