ADVANTAGES OF SHORT-TERM AND PROLONGED COURSES OF PREOPERATIVE RADIATION THERAPY FOR RECTAL CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-1-110-115

Published 01.01.2018

Oleg Kit⁺⁻
Yuriy Gevorkyan⁺⁻
Marina Gusareva⁺⁻
Lyudmila Rozenko⁺⁻
Natalya Soldatkina⁺⁻
Dmitriy Kharagezov⁺⁻
G. Beletskiy⁺⁻

Oleg Kit

Rostov Research Institute of OncologY

Yuriy Gevorkyan

Rostov Research Institute of OncologY

Marina Gusareva

Rostov Research Institute of OncologY

Lyudmila Rozenko

Rostov Research Institute of OncologY

Natalya Soldatkina

Rostov Research Institute of OncologY

Dmitriy Kharagezov

Rostov Research Institute of OncologY

G. Beletskiy

G.V. Bondar Republican Cancer Center

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Keywords

RECTAL CANCER
PREOPERATIVE RADIATION THERAPY
PROLONGED COURSE
SHORT-TERM COURSE

How to Cite

Kit, O., Gevorkyan, Y., Gusareva, M., Rozenko, L., Soldatkina, N., Kharagezov, D., & Beletskiy, G. (2018). ADVANTAGES OF SHORT-TERM AND PROLONGED COURSES OF PREOPERATIVE RADIATION THERAPY FOR RECTAL CANCER. Voprosy Onkologii, 64(1), 110–115. https://doi.org/10.37469/0507-3758-2018-64-1-110-115

Abstract

Results of preoperative radiation therapy for 119 patients with resectable rectal T3-4N0-1M0 cancer were analyzed. 52 patients received a short-term course of the large-fraction radiation therapy and 67 patients received a prolonged course of chemoradiation therapy. The results demonstrated that the prolonged course reduced clinical signs of the disease twice as much as the short course, it reduced the tumor size and increased the distance to the anorectal line (p<0.05) which increased the number of sphincter-preserving surgeries for cancer of the rectal lower ampulla. 1-year disease-free survival after the prolonged course was 20% higher in comparison with the short-term course (Long-Rank Test=0.045). 3-year disease-free and overall survival was similar in both groups of patients. The advantages of short and prolonged courses of preoperative radiation therapy for rectal cancer should be considered when planning the treatment.

https://doi.org/10.37469/0507-3758-2018-64-1-110-115

##article.numberofdownloads## 111

##article.numberofviews## 174

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