Abstract
Question on comprehensive dental care to patients with squamous cell carcinoma (SCC) of the mucous membrane of the oral cavity (MMOC) showed the importance of a team approach of physicians of allied specializations, careful planning and consistent implementation of rehabilitation treatment stages of cancer. The implementation of preventive measures showed a reduced severity or absence of complications conducted by the primary treatment. The data about the important role of preoperative sanitation of the oral cavity are presented. There are described the pathogenesis of the most common complications and identified effective methods of prevention and treatment, as well as the mechanisms of action of different prevention methods. Characteristic signs of “radiation caries”, oral mucositis, dysgeusia, xerostomia, lockjaw chewing muscles, osteoradionecrosis, dysphagia and neurotoxic effects of chemotherapy drugs are marked. It is necessary to emphasize the considerable effect of such complications on quality of life of patients after treatment. This again proves a need for an integrated approach and participation in the work of the specialists of a number of related disciplines.References
Кудасова Е.О., Муханов A.A., Холмогорова П.В. и др. Сравнение реакций тканей маргинального пародонта на различные конструкционные материалы съемных протетических конструкций // Международный научно-исследовательский журнал. - 2016. - Т. 50. - № 8-2. - С. 93-97.
Раджапова М.У., Мардынский Ю.С., Гулидов И.А. и др. Поздние лучевые повреждения при разнофракционной химиолучевой терапии рака орофарингеальной области // Российский онкологический журнал. - 2012. - № 3. - С. 19-22.
Сойхер М.И., Сойхер М.Г., Амхадова М.А. и др. Биосовместимая терапия в лечении пациентов с воспалительными заболеваниями пародонта // Медицинский алфавит. - 2016. - № 1 (2). - С. 9-23.
Утюж А.С., Юмашев А.В., Лушков Р.М. Клинический пример ортопедического лечения пациента после резекции нижней челюсти по поводу саркомы с использованием дентальных имплантатов // Клиническая стоматология. - 2016. - № 4 (80). - С. 56-58.
Фомин И.В. Лечение патологической стираемости зубов, осложненной дисфункцией височно - нижнечелюстного сустава. Внедрение результатов инновационных разработок: проблемы и перспективы // Сборник статей международной научно-практической конференции. - 2016. - С. 183-187.
Agarwal P., Shiva Kumar H.R., Rai K.K. Trismus in oral cancer patients undergoing surgery and radiotherapy // J. Oral. Biol. Craniofac. Res. - 2016. - Vol. 6(Suppl 1). - P S9-S13.
Al-Ansari S., Zecha J.A., Barasch A. et al. Oral Mucositis Induced By Anticancer Therapies // Curr. Oral. Health Rep. - 2015. - № 2(4). - P. 202-211.
Barkokebas A., Silva I.H., de Andrade S.C. et al. Impact of oral mucositis on oral-health-related quality of life of patients diagnosed with cancer // J. Oral. Pathol. Med. - 2015. - Vol. 44(9). - P. 746-751.
Bey A., Ahmed S.S., Hussain B. et al. Prevention and management of antineoplastic therapy induced oral mucositis -Natl. J. Maxillofac. Surg. - 2010. - Vol. 1(2). - P. 127-134.
Brody S., Omer O., McLoughlin J., Stassen L. The dentist>s role within the multi-disciplinary team maintaining quality of life for oral cancer patients in light of recent advances in radiotherapy // J. Ir. Dent. Assoc. - 2013. -Vol. 59(3). - P. 137-146.
Buglione M., Cavagnini R., Di Rosario F. et al. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation:Xerostomia and trismus (Part 2). Literature review and consensus statement // Crit. Rev. Oncol. Hematol. - 2016. - Vol. 102. - P 47-54.
Butterworth C., McCaul L., Barclay C.J. Restorative dentistry and oral rehabilitation: United Kingdom National Multidisciplinary Guidelines // Laryngol. Otol. - 2016. -Vol. 130(S2). - P S41-S44.
Carlos A.M. M. G. Sarriôn-Pérez. Prevention and treatment of oral mucositis in patients receiving chemotherapy // J. Clin. Exp. Dent. - 2014. - Vol. 6(1). - P. e74-e80.
Chaveli-Lopez B., Bagan-Sebastian J.V. Treatment of oral mucositis due to chemotherapy // J. Clin. Exp. Dent. - 2016. - Vol. 8(2). - e201-9.
Cheng K.K., Lee V., Li C.H. et al. Impact of oral mucositis on short-term clinical outcomes in paediatric and adolescent patients undergoingchemotherapy // Support Care Cancer. - 2013. - Vol. 21(8). - P. 2145-2152.
Chung M.K., Kim do H., Ahn YC. et al. Randomized Trial of Vitamin C/E Complex for Prevention of Radiation-Induced Xerostomia in Patients with Head and Neck Cancer // Otolaryngol. Head Neck Surg. - 2016. - Vol. 155(3). - P. 423-430.
Courtemanche H., Magot A., Ollivier Y. et al. Vincristine-induced neuropathy: Atypical electrophysiological patterns in children // Muscle Nerve. - 2015. - Vol. 52(6). - P. 981-985.
Deboni A.L., Giordani A.J., Lopes N.N. et al. Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer // Support Care Cancer. - 2012. - Vol. 20(11). - P. 2903-2911.
De Sanctis V., Bossi P., Sanguineti G. et al. Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements // Crit. Rev. Oncol. Hematol. - 2016. - Vol. 100. - P. 147-166.
Dirix P., Nuyts S. Evidence-based organ-sparing radiotherapy in head and neck cancer // Lancet Oncol. - 2010. - Vol. 11(1). - P. 85-91.
Faria K.M., Brandao T.B., Ribeiro A.C. et al. Micromorphology of the dental pulp is highly preserved in cancer patients who underwent head and neckradiotherapy // J Endod. - 2014. - Vol. 40(10). - P. 1553-1559.
Fleming S., Harrison S.J., Blombery P. et al. The choice of multiple myeloma induction therapy affects the frequency and severity of oral mucositis after melphalan-based autologous stem cell transplantation // Clin. Lymphoma Myeloma Leuk. - 2014. - Vol. 14(4). - P. 291-296.
Fox N.F., Xiao C., Sood A.J. et al. Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. - 2015. - Vol. 120(1). - P. 22-28.
van der Geer S.J., Kamstra J.I., Roodenburg J.L. et al. Predictors for trismus in patients receiving radiotherapy // Acta Oncol. - 2016. - Vol. 55(11). - P. 1318-1323.
Gevorgyan A., Wong K., Poon I. et al. Osteoradionecrosis of the mandible: a case series at a single institution // J. Otolaryngol. Head Neck Surg. - 2013. - Vol. 42. - P. 46.
Heijnen B.J., Speyer R., Kertscher B. et al. Dysphagia, Speech, Voice, and Trismus following Radiotherapy and/ or Chemotherapy in Patients with Head and Neck Carcinoma: Review of the Literature // Biomed Res. Int. -2016. - P. 6086894.
Herce-Lopez J., Rollon-Mayordomo A., Lozano-Rosado R. et al. Assessment of quality of life of oral cancer survivors compared with Spanish population norms // Int. J. Oral. Maxillofac. Surg. - 2013. - Vol. 42(4). - P. 446-452.
Huang C.C., Ou C.V., Lee W.T. et al. Life expectancy and expected years of life lost to oral cancer in Taiwan: a nation-wide analysis of 22, 024 cases followed for 10 years. // Oral Oncol. - 2015. - Vol. 51(4). - P. 349-354.
Hu J.Y., Li Y.Q., Smales R.J., Yip K.H. Restoration of teeth with more-viscous glass ionomer cements following radiation-induced caries // Int. Dent. J. - 2002. - Vol. 52(6). - P. 445-448.
Imai H., Soeda H., Komine K. et al. Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer // BMC Palliat. Care. - 2013. - Vol. 12(1). - P. 38.
Jha N., Seikaly H., Mcgaw T., Coulter L. Submandibular salivary gland transfer prevents radiation-induced xerostomia - evaluation of a symptom with increasing significance // International Journal of Radiation Oncology. - 47. 2000. - № 1(46). - P. 7-11.
Khaw A., Liberali S., Logan R. et al. Influence of periodontitis on the experience of oral mucositis in cancer patients undergoing head and neckradiotherapy: a pilot study // Support Care Cancer. - 2014. - Vol. 22(8). - P. 2119-2125.
Kubota K., Kobayashi W., Sakaki H. et al. Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer // Support Care Cancer. - 2015. - Vol. 23(11). - P. 3323-3329.
Lacatusu S., Frâncu L., Frâncu D. Clinical and therapeutical aspects of rampant caries in cervico-facial irradiated patients // Rev. Med. Chir. Soc. Med. Nat. Iasi. - 1996. - Vol. 100(3-4). - P. 198-202.
Lambade P.N., Lambade D., Goel M. Osteoradionecrosis of the mandible: a review // Oral Maxillofac Surg. - 2013. - Vol. 17(4). - P. 243-249.
Lovelace T.L., Fox N.F., Sood A.J. et al. Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: meta-analysis and literature review // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. - 2014. -Vol. 117(5). - P. 595-607.
Mercadante S., Aielli F., Adile C. et al. Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients // Support Care Cancer. - 2015. - Vol. 23(11). - P. 3249-3255.
Meurman J.H., Grönroos L. Oral and dental health care of oral cancer patients: hyposalivation, caries and infections // Oral Oncol. - 2010. - Vol. 46(6). - P. 464467.
Michelet M. Caries and periodontal disease in cancer survivors // Evid. Based Dent. - 2012. - Vol. 13(3). - P. 70-73.
Mosel D.D., Bauer R.L., Lynch D.P., Hwang S.T. Oral complications in the treatment of cancer patients // Oral Dis. -2011. - Vol. 17(6). - P. 550-559.
Mohammadi N., Seyednejad F., Oskoee P.A. et al. Evaluation of Radiation-induced Class V Dental Caries in Patients with Head and Neck Cancers Undergoing Radiotherapy // J. Dent. Res. Dent. Clin. Dent. Prospects. - 2008. - Vol. 2(3). - P. 82-84.
Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®): Patient Version. PDQ Supportive and Palliative Care Editorial Board. Source PDQ // National Cancer Institute (US). - 2002-2016.
Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®): Health Professional Version. PDQ Supportive and Palliative Care Editorial Board // National Cancer Institute (US). - 2016.
Nagaraja S., Kadam S.A., Selvaraj K. et al. Trismus in head and neck cancer patients treated by telecobalt and effect of early rehabilitation measures // J. Cancer Res. Ther. - 2016. - Vol. 12(2). - P. 685-688.
Niewald M., Fleckenstein J., Mang K. et al. Dental status, dental rehabilitation procedures, demographic and oncological data as potential risk factors for infected osteoradionecrosis of the lower jaw after radiotherapy for oral neoplasms: a retrospective evaluation // Radiat. Oncol. - 2013. - Vol. 8. - P. 227.
Patel U.H., Mir M.A., Sivik J.K. et al. Central neurotoxicity of immunomodulatory drugs in multiple myeloma // Hematol. Rep. - 2015. - Vol. 7(1). - P. 5704.
PDQ Supportive and Palliative Care Editorial Board. Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®): Patient Version. - National Cancer Institute (US). - 2016.
Petrosyan V., Ball D., Harrison R., Ameerally P Among Patients Undergoing Ablative Treatment for Oral Cancer, Does the Provision of Oral Rehabilitation Improve the Quality of Life? A Review of the Current Literature // J. Oral. Maxillofac. Surg. - 2016. - Vol. 74(5). - P. 1096.e1-1096.e12.
Rouers M., Truntzer P., Dubourg S. et al. Dental state in patients with head and neck cancers // Cancer Radiother. - 2015. - № 3. - P 205-210.
Saito N., Imai Y., Muto T., Sairenchi T. Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy // Support Care Cancer. - 2012. - Vol. 20(12). - P 3373-3377.
Sapir E., Tao Y., Feng F. et al. Predictors of Dysgeusia in Patients With Oropharyngeal Cancer Treated With Chemotherapy and Intensity Modulated Radiation Therapy // Int. J. Radiat. Oncol. Biol. Phys. - 2016. - Vol. 96(2). - P. 354-361.
Scherpenhuizen A., van Waes A.M., Janssen L.M. et al. The effect of exercise therapy in head and neck cancer patients in the treatment of radiotherapy-induced trismus: A systematic review // Oral Oncol. - 2015. - Vol. 51(8). - P. 745-750.
Schindler A., Denaro N., Russi E.G. et al. Dysphagia in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus // Crit. Rev. Oncol Hematol. - 2015. - Vol. 96(2). - P. 372-384.
Schweyen R., Hey J., Fränzel W. et al. Radiation-related caries: etiology and possible preventive strategies. What should the radiotherapist know? // Strahlenther Onkol. - 2012. - Vol. 188(1). - P 21-28.
Shavi G.R., Thakur B., Bhambal A. et al. Oral Health Related Quality of Life in Patients of Head and Neck Cancer Attending Cancer Hospital of Bhopal CitY., India // J. Int. Oral. Health. - 2015. - Vol. 7(8). - P. 21-27.
Shigeishi H., Ohta K., Fujimoto S. et al. Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients // Exp. Ther. Med. - 2016. - Vol. 12(3). - P. 1922-1928.
Spivakovsky S. Oral cryotherapy reduced oral mucositis in patients having cancer treatments // Evid. Based Dent. -2016. - Vol. 17(3). - P. 80.
Sood A.J., Fox N.F., O>Connell B.P et al. Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis // Oral Oncol. - 2014. - Vol. 50(2). - P. 77-83.
Tanaka Y., Takahashi T., Yamaguchi K. et al. Elemental diet plus glutamine for the prevention of mucositis in esophageal cancer patients receiving chemotherapy: a feasibility study // Support Care Cancer. - 2016. - Vol. 24(2). - P. 943.
Teguh D.N., Levendag PC., Ghidey W. et al. Risk model and nomogram for Dysphagia and xerostomia prediction in head and neck cancer patients treated by radiotherapy and/or chemotherapy // Dysphagia. - 2013. - Vol. 28(3). - P. 388-394.
Tsai C.C., Wu S.L., Lin S.L. et al. Reducing Trismus After Surgery and Radiotherapy in Oral Cancer Patients: Results of Alternative Operation Versus Traditional Operation // J. Oral. Maxillofac. Surg. - 2016. - Vol. 74(5). - P. 1072-1083.
Tsutsumi R., Goda M., Fujimoto C. et al. Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer // Laryngoscope. -2016. - Vol. 126(3). - P E103-9.
Wang X., Eisbruch A. IMRT for head and neck cancer: reducing xerostomia and dysphagia // J. Radiat. Res. - 2016. - Vol. 57(Suppl 1). - P. i69-i75.
Wodzinski A. Potential Benefits of Oral Cryotherapy for Chemotherapy-Induced Mucositis // Clin. J. Oncol. Nurs. - 2016. - Vol. 20(5). - P. 462-465.
Wong H.M. Oral complications and management strategies for patients undergoing cancer therapy // Scientific World Journal. - 2014. - Vol. 8. - P 581795.
Xu J.L., Xia R., Sun Z.H. et al. Effects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis ofrandomized controlled trials // Int. J. Oral. Maxillofac. Surg. - 2016.
Yang W.F., Liao G.Q., Hakim S.G. et al. Is Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-analysis // Int. J. Radiat. Oncol. Biol. Phys. - 2016. - Vol. 94(3). - P 503-511.
Yonekita H., Takase H., Ogata K. et al. The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer // Gan To Kagaku Ryoho. - 2014. - Vol. 41(13). - P. 2571-2575.
Zhang J., Liu H., Liang X. et al. Investigation of salivary function and oral microbiota of radiation caries-free people with nasopharyngeal carcinoma // PLoS One. - 2015. - 10(4). - P. e0123137.
Gupta N., Pal M., Rawat S. et al. Radiation-induced dental caries, prevention and treatment - A systematic review // Natl. J. Maxillofac. Surg. - 2015. - Vol. 6(2). - P 160-166.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2018