Vol. 65 No. 3 (2019), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 65 No. 3 (2019)

OPPORTUNITIES IN DIAGNOSTICS OF PANCREATIC METASTATIC TUMORS BY CYTOLOGICAL METHOD

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-3-409-413

Published 01.03.2019

Andrey Mikhetko⁺⁻
Olga Ivko⁺⁻
Sergey Petrik⁺⁻
O. Tkachenko⁺⁻
M. Grinkevich⁺⁻
A. Sidorova⁺⁻
Yu. Petrik⁺⁻
Yekaterina Shalina⁺⁻
Andrey Mikhetko⁺⁻

Andrey Mikhetko

N.N. Petrov Cancer Research Center

Olga Ivko

N.N. Petrov Cancer Research Center

Sergey Petrik

N.N. Petrov Cancer Research Center

O. Tkachenko

N.N. Petrov Cancer Research Center

M. Grinkevich

N.N. Petrov Cancer Research Center

A. Sidorova

N.N. Petrov Cancer Research Center

Yu. Petrik

N.N. Petrov Cancer Research Center

Yekaterina Shalina

N.N. Petrov Cancer Research Center

Andrey Mikhetko

N.N. Petrov Cancer Research Center

PDF (Русский)

Keywords

PANCREAS
METASTATIC LESIONS
FINE NEEDLE ASPIRATIONS
OYTOLOGICAL DIAGNOSTIC
CYTOLOGICAL EXAMINATION

How to Cite

Mikhetko, A., Ivko, O., Petrik, S., Tkachenko, O., Grinkevich, M., Sidorova, A., Petrik, Y., Shalina, Y., & Mikhetko, A. (2019). OPPORTUNITIES IN DIAGNOSTICS OF PANCREATIC METASTATIC TUMORS BY CYTOLOGICAL METHOD. Voprosy Onkologii, 65(3), 409–413. https://doi.org/10.37469/0507-3758-2019-65-3-409-413

Abstract

Our study includes results of 152 pancreatic fine needle aspirations of solid and cystic tumors, from 149 patients of the N.N. Petrov Cancer Research Center for the 3-year period (2016 - 2018). Representative cell material for morphological studies was obtained in 97.4% of cases. The results of cytological examination of 111 patients with pancreatic tumors were compared with histological data. The effectiveness of cytological examination was 96.1%, sensitivity - 95.6%, specificity -100%. Metastatic lesions were presented in 9% (9 patients). In 9 diagnostically proven cases, the cytological result was correct 8 times. Cytological examination with immunocytochemistry is a valid and accurate diagnostic procedure for the evaluation of pancreatic tumors including metastatic lesions.

https://doi.org/10.37469/0507-3758-2019-65-3-409-413

PDF (Русский)

References

Двойникова Е.Р., Агапов М.Ю., Стегний К.В. Оценка эффективности эндосонографии и тонкоигольной пункции под контролем эндоскопической ультрасонографии при солидных образованиях поджелудочной железы на этапе освоения методики // Тихоокеанский медицинский журнал. - 2016. - № 1. - С. 66-68.

Попов С.А., Павловский А.В., Урбанский А.И. Эффективность чрескожной трепанобиопсии в диагностике новообразований поджелудочной железы // Вестник хирургии им. И.И. Грекова. - 2014. - №1. - С. 84-88.

Шапиро Н.А., Батороев Ю.К., Дворниченко В.В. Цитологическая диагностика опухолей печени, желчного пузыря и поджелудочной железы: цветной атлас. Под. ред. Н.А.Шапиро. - М., 2012. - 260 с.

Alzahrani M.A., Schmulewitz N., Grewal S. et al. Metastases to the pancreas: the experience of a high volume center and a review of the literature // J. Surg. Oncol. - 2012. - Vol. 105. - № 2. - P. 156-161.

Ardengh J.C., Lopes C.V., Kemp R. et al. Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases // BMC Gastroenterology. - 2013. - Vol. 13. - P. 63.

Atiq M., Bhutani M.S., Ross W.A. Role of Endoscopic Ultrasonography in Evaluation of Metastatic Lesions to the Pancreas: A Tertiary Cancer Center Experience // Pancreas. - 2013. - Vol. 42. - № 2. - P 516-523.

Chan E.S., Alexander J., Swanson P.E. et al. PDX-1, CDX- 2, TTF-1, and CK7: a reliable immunohistochemical panel for pancreatic neuroendocrine neoplasms // Am. J. Surg. Pathol. - 2012. - Vol. 36. - № 5. - P. 737-743.

Ganjei-Azar P., Nadji M. Color Atlas of Immunocytochemistry in Diagnostic Cytology // Springer, 2007. - P. 296.

Gavini H., Arukala V.D., Stewart J., Lee J.H. Medulloblastoma metastatic to the pancreas: a case report // Gastrointestinal Intervention. - 2014. - Vol. 3. - №1. - P. 116-119.

Hou Y, Shen R., Tonkovich D., Li Z. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving pancreas: an institution's experience // Journal of the American Society of Cytopathology. - 2018. - Vol. 7. - № 5. - P. 261-267.

Layfield L.J., Jarboe E.A. Cytopathology of the pancreas: neoplastic and nonneoplastic entities // Annals of Diagnostic Pathology. - 2010. - Vol. 14. - № 2. - P. 140-151.

Layfield L.J., Hirschowitz S.L., Adler D.G. Metastatic disease to the pancreas documented by endoscopic ultrasound guided fine-needle aspiration: a seven-year experience // Diagn. Cytopathol. - 2012. - Vol. 40. - № 3. - P. 228-233.

Lin F, Staerkel G. Cytologic Criteria for welldifferentiated adenocarcinoma of the pancreas in fine-needle aspiration biopsy specimens // Cancer (Cancer Cytopathology). -2003. - Vol. 99. - № 1. - P. 44 -50.

Mizuno N., Hara K., Hijioka S. et al. Current Concept of Endoscopic Ultrasound-Guided Fine Needle Aspiration for Pancreatic Cancer // Pancreatology. - 2011. - Vol. 11. -№ 2. - P. 40-46.

Olson M.T., Wakely Jr P.E., Ali S.Z. Metastases to the pancreas diagnosed by fine-needle aspiration // Acta. Cytol. - 2013. - Vol. 57. - P. 473 - 480.

Pang JC, Roh MH. Metastases to the pancreas encountered on endoscopic ultrasound-guided, fine-needle aspiration // Arch. Pathol. Lab. Med. - 2015. -Vol. 139. - № 10. - P. 1248 - 1252.

Smith A.L., Odronic S.I., Springer B.S., Reynolds J.P. Solid tumor metastases to the pancreas diagnosed by FNA: a single-institution experience and review of the literature // Cancer Cytopathol. - 2015. - Vol. 123. -№ 6. - P. 347-355.

Syed Z. Ali, Yener S. Erozan, Ralph H. Hruban. Atlas of pancreatic cytopathology with histopathologic correlations / Ali, Syed Z. - New York: Demos Medical Publishing, 2009. -277 с.

Waters L., Si Q., Caraway N. et al. Secondary tumors of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration: a 10-year experience // Diagn Cytopathol. - 2014. - Vol. 42. - № 9. - P. 738-743.

Yang R.Y, Ng D., Jaskolka J.D. et al. Evaluation of percutaneous ultrasound-guided biopsies of solid mass lesions of the pancreas: a center's 10-year experience // Clinical Imaging. - 2015. - Vol. 39. - P. 62-65.

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