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Аннотация
Роль аутофагии и везикулярного транспорта в канцерогенезе, в том числе меланомы, неоднозначна: с одной стороны, они способствуют поддержанию внутриклеточного гомеостаза и прогрессированию рака, с другой стороны, могут быть направлены на инициацию клеточной гибели. Данные процессы оказывают значительное влияние на метаболизм клеток меланомы и ассоциируются с метастазированием, ростом и прогрессированием опухоли. В обзоре рассматриваются механизмы аутофагии и везикулярного транспорта и представлены современные литературные данные, демонстрирующие роль внутриклеточной транспортной системы в онкогенезе и развитии меланомы. Поиск научной литературы был выполнен в базе данных PubMed.
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