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摘要
Медуллобластома - наиболее распространенная злокачественная опухоль центральной нервной системы у детей, клинические проявления, ответ на проводимую терапию и прогноз которой значительно вариабельны. В многочисленных работах была продемонстрирована прогностическая значимость различных клинических, морфологических, цитогенетических и молекулярно-биологических характеристик заболевания. С внедрением в исследовательскую практику высокопроизводительных молекулярно-генетических технологий удалось идентифицировать четыре независимые подгруппы медуллобластомы, имеющие различный источник гистогенеза, молекулярный патогенез, клинические проявления и исход. Данный обзор посвящен молекулярно-биологическим свойствам медуллобластомы, лежащим в основе ее клинической гетерогенности и создающим основы стратификации пациентов для проведения риск-адаптированного и таргетного лечения.参考
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